| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GOLDMAN SACHS GROUP INC | 0 | 126,927 | +126,927 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 91,086 | +91,086 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 33,700 | 116,785 | +83,085 | 0.04 | 0.05 | +0.00 | buy |
| BML Capital Management, LLC | 335,000 | 400,000 | +65,000 | 13.27 | 4.74 | -8.53 | buy |
| Assenagon Asset Management S.A. | 0 | 62,558 | +62,558 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 53,253 | +53,253 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 9,953 | 57,942 | +47,989 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 17,222 | 61,633 | +44,411 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 107,545 | 148,017 | +40,472 | 6.47 | 2.48 | -3.99 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 96,855 | 133,755 | +36,900 | 0.01 | 0.00 | -0.01 | buy |
| 683 Capital Management, LLC | 0 | 34,557 | +34,557 | 0.00 | 0.06 | +0.06 | buy |
| XTX Topco Ltd | 3,605 | 12,533 | +8,928 | 0.02 | 0.02 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 23,707 | 31,708 | +8,001 | 0.27 | 0.12 | -0.14 | buy |
| BlackRock, Inc. | 52,794 | 59,767 | +6,973 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 65 | 3,076 | +3,011 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 60 | 2,827 | +2,767 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 12,182 | 14,795 | +2,613 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 40,131 | 41,735 | +1,604 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 963 | 1,410 | +447 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 23,426 | 23,698 | +272 | 0.00 | 0.00 | -0.00 | buy |
| BOKF, NA | 354 | 454 | +100 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 151,190 | 151,190 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 114 | 114 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 11,165 | 11,165 | 0 | 0.10 | 0.03 | -0.06 | hold |
| CPMG Inc | 410,922 | 410,922 | 0 | 24.17 | 25.82 | +1.65 | hold |
| VR Adviser, LLC | 33,177 | 33,177 | 0 | 0.12 | 0.04 | -0.07 | hold |
| Curative Ventures V LLC | 1,899,004 | 1,899,004 | 0 | 100.00 | 100.00 | 0.00 | hold |
| Frazier Financial Advisors, LLC | 15 | 15 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 192,433 | 192,433 | 0 | 0.65 | 0.16 | -0.49 | hold |
| FRED ALGER MANAGEMENT, LLC | 31,332 | 31,314 | -18 | 0.01 | 0.00 | -0.01 | sell |
| JONES FINANCIAL COMPANIES LLLP | 125 | 0 | -125 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 2,332 | 0 | -2,332 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,730 | 2,843 | -2,887 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,981 | 0 | -2,981 | 0.00 | 0.00 | -0.00 | sell |
| FORA Capital, LLC | 3,085 | 0 | -3,085 | 0.02 | 0.00 | -0.02 | sell |
| Virtu Financial LLC | 3,335 | 0 | -3,335 | 0.01 | 0.00 | -0.01 | sell |
| OMERS ADMINISTRATION Corp | 3,800 | 0 | -3,800 | 0.00 | 0.00 | -0.00 | sell |
| Beacon Pointe Advisors, LLC | 4,849 | 0 | -4,849 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 5,374 | 0 | -5,374 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 7,103 | 0 | -7,103 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 10,517 | 0 | -10,517 | 0.16 | 0.00 | -0.16 | sell |
| HRT FINANCIAL LP | 10,902 | 0 | -10,902 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 20,276 | 0 | -20,276 | 0.11 | 0.00 | -0.11 | sell |
| Avidity Partners Management LP | 29,100 | 0 | -29,100 | 0.10 | 0.00 | -0.10 | sell |
| Vivo Capital, LLC | 624,339 | 585,485 | -38,854 | 3.48 | 1.25 | -2.23 | sell |
| Point72 Asset Management, L.P. | 95,450 | 0 | -95,450 | 0.02 | 0.00 | -0.02 | sell |
| Invesco Ltd. | 145,118 | 0 | -145,118 | 0.00 | 0.00 | -0.00 | sell |
| Commodore Capital LP | 150,929 | 0 | -150,929 | 0.63 | 0.00 | -0.63 | sell |
| PERCEPTIVE ADVISORS LLC | 345,545 | 0 | -345,545 | 0.50 | 0.00 | -0.50 | sell |