| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 7,648,268 | 9,731,341 | +2,083,073 | 8.39 | 10.81 | +2.41 | buy |
| Lynx1 Capital Management LP | 8,963,500 | 8,963,500 | 0 | 20.13 | 18.86 | -1.27 | hold |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 2.60 | 2.68 | +0.07 | hold |
| BlackRock, Inc. | 4,449,966 | 5,232,766 | +782,800 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,029,719 | 3,825,950 | +1,796,231 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,544,115 | 3,668,627 | +1,124,512 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 3,114,132 | 3,114,132 | 0 | 2.81 | 3.13 | +0.33 | hold |
| RTW INVESTMENTS, LP | 1,705,960 | 2,364,347 | +658,387 | 0.24 | 0.37 | +0.13 | buy |
| Siren, L.L.C. | 1,193,410 | 1,893,410 | +700,000 | 0.47 | 0.70 | +0.23 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,368,268 | 1,547,309 | +179,041 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 1,909,764 | 1,539,764 | -370,000 | 7.29 | 4.26 | -3.03 | sell |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 0.73 | 0.76 | +0.03 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,112,803 | 1,082,611 | -30,192 | 0.36 | 0.37 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 906,028 | 1,046,694 | +140,666 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 455,449 | 1,001,598 | +546,149 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 781,260 | 875,760 | +94,500 | 0.65 | 0.78 | +0.13 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 704,442 | +704,442 | 0.00 | 3.00 | +3.00 | buy |
| MORGAN STANLEY | 589,483 | 629,035 | +39,552 | 0.00 | 0.00 | +0.00 | buy |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 0.97 | 1.10 | +0.13 | hold |
| AQR CAPITAL MANAGEMENT LLC | 360,874 | 581,338 | +220,464 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 449,258 | 571,080 | +121,822 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 516,724 | 510,325 | -6,399 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 805,700 | 471,947 | -333,753 | 0.00 | 0.00 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 464,034 | +464,034 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 432,893 | 464,034 | +31,141 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 426,478 | +426,478 | 0.00 | 0.12 | +0.12 | buy |
| TCG Crossover Management, LLC | 406,786 | 406,786 | 0 | 0.17 | 0.18 | +0.01 | hold |
| CITADEL ADVISORS LLC | 252,778 | 397,484 | +144,706 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 367,906 | 382,840 | +14,934 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 346,582 | 346,232 | -350 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 324,111 | 326,811 | +2,700 | 0.01 | 0.01 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 300,000 | 300,000 | 0 | 1.04 | 1.29 | +0.24 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 289,115 | 292,500 | +3,385 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 297,231 | 282,631 | -14,600 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 522,047 | 272,581 | -249,466 | 0.01 | 0.00 | -0.00 | sell |
| Bleichroeder LP | 100,000 | 250,000 | +150,000 | 0.25 | 0.81 | +0.57 | buy |
| UBS Group AG | 202,385 | 248,627 | +46,242 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,232 | 240,115 | +232,883 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 238,000 | +238,000 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 233,842 | 233,842 | 0 | 0.05 | 0.07 | +0.02 | hold |
| PFM Health Sciences, LP | 227,406 | 192,442 | -34,964 | 0.34 | 0.30 | -0.04 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 105,960 | 189,946 | +83,986 | 0.05 | 0.08 | +0.02 | buy |
| Bank of New York Mellon Corp | 143,708 | 171,031 | +27,323 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 168,117 | +168,117 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 149,445 | 167,555 | +18,110 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 149,626 | 164,716 | +15,090 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 144,107 | 156,317 | +12,210 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 66,288 | 153,050 | +86,762 | 0.01 | 0.04 | +0.02 | buy |
| Trexquant Investment LP | 168,473 | 152,163 | -16,310 | 0.02 | 0.02 | -0.00 | sell |
| BARCLAYS PLC | 140,295 | 143,945 | +3,650 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 244,150 | 143,552 | -100,598 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 193,800 | 138,708 | -55,092 | 0.04 | 0.02 | -0.02 | sell |
| CITIGROUP INC | 144,111 | 124,409 | -19,702 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 72,282 | 109,876 | +37,594 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 59,974 | 86,458 | +26,484 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 67,656 | 84,178 | +16,522 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 95,417 | 80,648 | -14,769 | 0.03 | 0.03 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 114,400 | 80,628 | -33,772 | 0.00 | 0.00 | -0.00 | sell |
| APIS CAPITAL ADVISORS, LLC | 60,000 | 80,000 | +20,000 | 0.13 | 0.14 | +0.01 | buy |
| RHUMBLINE ADVISERS | 67,516 | 78,930 | +11,414 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 26,324 | 76,965 | +50,641 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75,310 | 76,711 | +1,401 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 58,300 | 76,000 | +17,700 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 47,630 | 75,250 | +27,620 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 905,376 | 75,009 | -830,367 | 0.02 | 0.00 | -0.02 | sell |
| Mariner, LLC | 62,718 | 74,273 | +11,555 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 24,200 | 69,182 | +44,982 | 0.20 | 0.67 | +0.46 | buy |
| Rafferty Asset Management, LLC | 69,485 | 66,092 | -3,393 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 1,049,581 | 66,051 | -983,530 | 0.02 | 0.00 | -0.01 | sell |
| Longaeva Partners L.P. | 183,691 | 64,785 | -118,906 | 0.13 | 0.03 | -0.09 | sell |
| Tidal Investments LLC | 62,421 | 62,826 | +405 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 62,421 | 62,826 | +405 | 0.06 | 0.04 | -0.02 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 61,938 | +61,938 | 0.00 | 0.03 | +0.03 | buy |
| Assenagon Asset Management S.A. | 138,705 | 61,682 | -77,023 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 27,885 | 54,877 | +26,992 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 51,491 | 53,010 | +1,519 | 0.02 | 0.02 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,939 | 51,256 | +30,317 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 410,200 | 50,000 | -360,200 | 0.24 | 0.03 | -0.20 | sell |
| FRANKLIN RESOURCES INC | 0 | 42,345 | +42,345 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,397 | 40,253 | +9,856 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 109,731 | 36,851 | -72,880 | 0.02 | 0.01 | -0.02 | sell |
| Fisher Asset Management, LLC | 0 | 35,998 | +35,998 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 30,816 | 35,746 | +4,930 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,151 | 35,535 | +5,384 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 27,736 | 33,720 | +5,984 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 31,251 | 33,403 | +2,152 | 0.02 | 0.02 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 31,713 | +31,713 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 4,272 | 28,537 | +24,265 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 28,537 | +28,537 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 28,158 | 28,061 | -97 | 0.20 | 0.18 | -0.01 | sell |
| Legal & General Group Plc | 18,701 | 27,477 | +8,776 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,377 | 26,090 | -21,287 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 24,396 | +24,396 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 22,875 | 23,883 | +1,008 | 0.09 | 0.10 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 28,988 | 22,518 | -6,470 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 14,109 | 21,922 | +7,813 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,918 | 21,218 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,067 | 20,348 | +1,281 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 20,279 | +20,279 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 20,050 | +20,050 | 0.00 | 0.00 | +0.00 | buy |