| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 18.23 | 20.95 | +2.72 | hold |
| BVF INC/IL | 3,196,701 | 3,196,701 | 0 | 0.82 | 1.50 | +0.68 | hold |
| Blue Owl Capital Holdings LP | 3,419,842 | 2,924,842 | -495,000 | 8.33 | 9.96 | +1.63 | sell |
| FRANKLIN RESOURCES INC | 3,281,280 | 2,696,762 | -584,518 | 0.02 | 0.01 | -0.00 | sell |
| VANGUARD GROUP INC | 1,771,443 | 1,774,345 | +2,902 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 565,404 | 1,425,459 | +860,055 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,348,015 | +1,348,015 | 0.00 | 0.81 | +0.81 | buy |
| BRAIDWELL LP | 1,240,865 | 1,240,865 | 0 | 0.46 | 0.68 | +0.22 | hold |
| MORGAN STANLEY | 919,899 | 1,152,644 | +232,745 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,138,531 | +1,138,531 | 0.00 | 0.34 | +0.34 | buy |
| CITADEL ADVISORS LLC | 1,132,889 | 1,109,171 | -23,718 | 0.01 | 0.02 | +0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 915,758 | 993,377 | +77,619 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 950,000 | +950,000 | 0.00 | 0.03 | +0.03 | buy |
| Logos Global Management LP | 0 | 700,000 | +700,000 | 0.00 | 1.26 | +1.26 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 655,664 | 677,330 | +21,666 | 0.00 | 0.00 | +0.00 | buy |
| Rubric Capital Management LP | 626,929 | 626,929 | 0 | 0.24 | 0.32 | +0.08 | hold |
| TANG CAPITAL MANAGEMENT LLC | 771,138 | 571,138 | -200,000 | 0.73 | 1.01 | +0.29 | sell |
| DEUTSCHE BANK AG\ | 545,584 | 549,276 | +3,692 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 544,848 | 517,606 | -27,242 | 0.11 | 0.16 | +0.05 | sell |
| AMERIPRISE FINANCIAL INC | 54,921 | 420,217 | +365,296 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 264,088 | 321,100 | +57,012 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 266,922 | 263,949 | -2,973 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 300,000 | 258,588 | -41,412 | 0.61 | 0.72 | +0.11 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 246,705 | 257,873 | +11,168 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 255,967 | +255,967 | 0.00 | 0.22 | +0.22 | buy |
| Parkman Healthcare Partners LLC | 529,877 | 178,396 | -351,481 | 0.76 | 0.37 | -0.39 | sell |
| GOLDMAN SACHS GROUP INC | 128,315 | 169,367 | +41,052 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 140,779 | 166,740 | +25,961 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 135,412 | 131,349 | -4,063 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 6,846 | 115,112 | +108,266 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 97,055 | +97,055 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 92,875 | 95,771 | +2,896 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 99,003 | 94,240 | -4,763 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 10,570 | 85,574 | +75,004 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 160,012 | 84,234 | -75,778 | 0.04 | 0.03 | -0.01 | sell |
| ALGERT GLOBAL LLC | 41,020 | 79,680 | +38,660 | 0.02 | 0.05 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 68,358 | +68,358 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 48,919 | 61,621 | +12,702 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 141,000 | 60,074 | -80,926 | 0.01 | 0.01 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 54,352 | 59,352 | +5,000 | 0.02 | 0.03 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 41,453 | 57,178 | +15,725 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 56,926 | 55,888 | -1,038 | 0.01 | 0.01 | +0.00 | sell |
| Invesco Ltd. | 10,623 | 47,407 | +36,784 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 33,374 | 47,044 | +13,670 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 45,730 | 46,702 | +972 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 46,300 | 46,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 42,529 | 42,529 | 0 | 0.01 | 0.01 | +0.01 | hold |
| BARCLAYS PLC | 85,224 | 40,192 | -45,032 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 36,401 | +36,401 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,964 | 34,615 | +14,651 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 43,380 | 33,200 | -10,180 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 0 | 31,900 | +31,900 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 25,114 | 25,114 | 0 | 0.20 | 0.35 | +0.15 | hold |
| Nebula Research & Development LLC | 0 | 24,653 | +24,653 | 0.00 | 0.09 | +0.09 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,201 | 23,752 | -1,449 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,022 | 22,842 | +820 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 21,690 | +21,690 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 33,759 | 21,250 | -12,509 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 21,004 | +21,004 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 40,125 | 20,225 | -19,900 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 20,095 | +20,095 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 38,600 | 19,600 | -19,000 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 14,009 | 19,561 | +5,552 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 25,193 | 19,470 | -5,723 | 0.00 | 0.00 | +0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 18,718 | 18,579 | -139 | 0.03 | 0.05 | +0.02 | sell |
| Mirae Asset Global Investments Co., Ltd. | 14,135 | 17,269 | +3,134 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 14,076 | 16,850 | +2,774 | 0.00 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 15,906 | 16,388 | +482 | 0.02 | 0.02 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 29,637 | 16,347 | -13,290 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 15,263 | +15,263 | 0.00 | 0.01 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 20,959 | 14,704 | -6,255 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 13,337 | 13,337 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 1,236,564 | 12,742 | -1,223,822 | 0.05 | 0.00 | -0.05 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 14,463 | 12,540 | -1,923 | 0.03 | 0.03 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,692 | 10,782 | +90 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 10,879 | 10,181 | -698 | 0.07 | 0.09 | +0.02 | sell |
| SG Americas Securities, LLC | 14,449 | 9,936 | -4,513 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,686 | 9,510 | +2,824 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,027 | 9,200 | +1,173 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,954 | 8,996 | +4,042 | 0.01 | 0.02 | +0.01 | buy |
| AlphaQuest LLC | 17,601 | 8,683 | -8,918 | 0.04 | 0.03 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,542 | 5,125 | -1,417 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,984 | 2,599 | +615 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 1,317 | 1,317 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,286 | 1,286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 2,170 | 896 | -1,274 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Advisors, LLC | 0 | 723 | +723 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 442 | 526 | +84 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 412 | 496 | +84 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 858 | 451 | -407 | 0.00 | 0.00 | -0.00 | sell |
| Pacer Advisors, Inc. | 0 | 450 | +450 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 504 | 428 | -76 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 10,234 | 325 | -9,909 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 241 | 306 | +65 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 244 | +244 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 117 | 138 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 127 | 127 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Washington Trust Advisors, Inc. | 127 | 127 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 122 | 122 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 511 | 119 | -392 | 0.00 | 0.00 | -0.00 | sell |