| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 1,257,795 | 3,215,722 | +1,957,927 | 5.74 | 8.72 | +2.97 | buy |
| Kynam Capital Management, LP | 1,252,738 | 2,338,629 | +1,085,891 | 1.01 | 1.51 | +0.51 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,379,399 | 3,860,839 | +481,440 | 0.78 | 0.58 | -0.20 | buy |
| BANK OF AMERICA CORP /DE/ | 155,270 | 524,385 | +369,115 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 921,138 | 1,121,138 | +200,000 | 0.74 | 0.47 | -0.27 | buy |
| ALGERT GLOBAL LLC | 43,292 | 221,430 | +178,138 | 0.01 | 0.04 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 190,508 | 363,008 | +172,500 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,936,227 | 3,039,731 | +103,504 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 81,721 | +81,721 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 80,100 | +80,100 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 0 | 68,467 | +68,467 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 2,370,972 | 2,435,972 | +65,000 | 6.65 | 5.95 | -0.71 | buy |
| CITADEL ADVISORS LLC | 2,682,904 | 2,747,145 | +64,241 | 0.03 | 0.02 | -0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 20,273 | 77,621 | +57,348 | 0.00 | 0.00 | +0.00 | buy |
| Voss Capital, LP | 122,361 | 175,000 | +52,639 | 0.11 | 0.10 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,736 | 79,438 | +43,702 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 235,713 | 278,819 | +43,106 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 34,396 | +34,396 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 29,505 | +29,505 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 0 | 29,363 | +29,363 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 29,175 | +29,175 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 132,976 | 161,057 | +28,081 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,214,641 | 1,241,817 | +27,176 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 14,735 | 40,599 | +25,864 | 0.00 | 0.01 | +0.00 | buy |
| AlphaQuest LLC | 0 | 25,090 | +25,090 | 0.00 | 0.02 | +0.02 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 21,581 | +21,581 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 20,850 | +20,850 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,199,709 | 2,219,761 | +20,052 | 0.01 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 31,782 | 49,878 | +18,096 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 16,268 | +16,268 | 0.00 | 0.04 | +0.04 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 15,746 | +15,746 | 0.00 | 0.06 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 115,000 | 129,721 | +14,721 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 0 | 14,255 | +14,255 | 0.00 | 0.04 | +0.04 | buy |
| Virtus Investment Advisers, LLC | 0 | 13,455 | +13,455 | 0.00 | 0.03 | +0.03 | buy |
| Creative Planning | 0 | 12,950 | +12,950 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 100,721 | 112,670 | +11,949 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 23,500 | 35,200 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 11,597 | +11,597 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 28,433 | 39,164 | +10,731 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 28,433 | 39,164 | +10,731 | 0.14 | 0.09 | -0.06 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,152 | +10,152 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 14,657 | 24,190 | +9,533 | 0.08 | 0.08 | +0.01 | buy |
| Corton Capital Inc. | 11,944 | 16,842 | +4,898 | 0.08 | 0.42 | +0.34 | buy |
| Brooklyn Investment Group | 0 | 4,503 | +4,503 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 9,891 | 14,107 | +4,216 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 21,900 | 25,100 | +3,200 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 68,208 | 71,338 | +3,130 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 241 | 2,972 | +2,731 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,493 | 31,721 | +2,228 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 1,403 | 3,598 | +2,195 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 213 | 1,557 | +1,344 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 43,399 | 44,493 | +1,094 | 0.04 | 0.02 | -0.03 | buy |
| Farther Finance Advisors, LLC | 0 | 1,013 | +1,013 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 24,864 | 25,687 | +823 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,504 | 15,160 | +656 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 576 | +576 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 401 | +401 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 532 | 924 | +392 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 16 | 389 | +373 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,983 | 33,319 | +336 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 80,673 | 81,000 | +327 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,223 | 1,491 | +268 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 245 | +245 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 241 | +241 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 207 | +207 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,940 | 1,974 | +34 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 47 | 73 | +26 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,240 | 5,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 2.37 | 1.77 | -0.60 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,251 | 31,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 36 | 36 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Amundi | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 31,893 | 31,893 | 0 | 0.14 | 0.09 | -0.05 | hold |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 1.07 | 0.70 | -0.37 | hold |
| Daiwa Securities Group Inc. | 218 | 218 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,705,960 | 1,705,960 | 0 | 0.31 | 0.20 | -0.12 | hold |
| Swiss National Bank | 62,700 | 62,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 1.15 | 0.89 | -0.26 | hold |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.20 | 0.13 | -0.07 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 13.23 | 9.95 | -3.27 | hold |
| KLP KAPITALFORVALTNING AS | 6,800 | 6,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 263,817 | 263,817 | 0 | 0.50 | 0.31 | -0.19 | hold |
| Patient Square Capital LP | 878,897 | 878,897 | 0 | 4.00 | 2.75 | -1.25 | hold |
| SBI Securities Co., Ltd. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Washington Trust Advisors, Inc. | 127 | 127 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Foresite Capital Management VI LLC | 634,558 | 634,558 | 0 | 3.44 | 2.63 | -0.81 | hold |
| Police & Firemen's Retirement System of New Jersey | 10,582 | 10,582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,150 | 1,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 42,808 | 42,808 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,918 | 12,918 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,768 | 1,768 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 145 | 100 | -45 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 242 | 146 | -96 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 25,719 | 25,603 | -116 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 137 | 21 | -116 | 0.00 | 0.00 | -0.00 | sell |