| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 8,963,500 | 8,963,500 | 0 | 18.78 | 20.13 | +1.35 | hold |
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 9.06 | 8.39 | -0.66 | hold |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 2.00 | 2.60 | +0.60 | hold |
| BlackRock, Inc. | 4,400,296 | 4,449,966 | +49,670 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 3,114,132 | 3,114,132 | 0 | 2.10 | 2.81 | +0.71 | hold |
| STATE STREET CORP | 2,197,338 | 2,544,115 | +346,777 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 47,187 | 2,029,719 | +1,982,532 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 2,350,972 | 1,909,764 | -441,208 | 7.51 | 7.29 | -0.22 | sell |
| RTW INVESTMENTS, LP | 1,705,960 | 1,705,960 | 0 | 0.18 | 0.24 | +0.06 | hold |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 0.71 | 0.73 | +0.03 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,302,262 | 1,368,268 | +66,006 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 1,193,410 | 1,193,410 | 0 | 0.37 | 0.47 | +0.10 | hold |
| Nextech Invest, Ltd. | 1,141,145 | 1,141,145 | 0 | 1.14 | 1.14 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,237,043 | 1,112,803 | -124,240 | 0.33 | 0.36 | +0.04 | sell |
| MARSHALL WACE, LLP | 414,359 | 1,049,581 | +635,222 | 0.00 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 848,769 | 906,028 | +57,259 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 360,162 | 905,376 | +545,214 | 0.01 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 579,095 | 805,700 | +226,605 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,932,106 | 781,260 | -1,150,846 | 1.44 | 0.65 | -0.79 | sell |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 0.71 | 0.97 | +0.26 | hold |
| MORGAN STANLEY | 766,934 | 589,483 | -177,451 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 470,526 | 522,047 | +51,521 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 346,307 | 516,724 | +170,417 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 721,864 | 455,449 | -266,415 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 421,635 | 449,258 | +27,623 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 436,273 | 432,893 | -3,380 | 0.00 | 0.00 | +0.00 | sell |
| Soleus Capital Management, L.P. | 0 | 410,200 | +410,200 | 0.00 | 0.24 | +0.24 | buy |
| TCG Crossover Management, LLC | 0 | 406,786 | +406,786 | 0.00 | 0.17 | +0.17 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 386,169 | 386,169 | 0 | 0.05 | 0.06 | +0.01 | hold |
| DEUTSCHE BANK AG\ | 586,636 | 367,906 | -218,730 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 281,483 | 360,874 | +79,391 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 362,495 | 346,582 | -15,913 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 631,706 | 324,111 | -307,595 | 0.01 | 0.01 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 634,032 | 300,000 | -334,032 | 2.13 | 1.04 | -1.08 | sell |
| JPMORGAN CHASE & CO | 147,055 | 297,231 | +150,176 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 244,022 | 289,115 | +45,093 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 110,317 | 252,778 | +142,461 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 130,323 | 244,150 | +113,827 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 270,006 | 243,006 | -27,000 | 0.06 | 0.08 | +0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 233,842 | 233,842 | 0 | 0.04 | 0.05 | +0.01 | hold |
| PFM Health Sciences, LP | 227,003 | 227,406 | +403 | 0.24 | 0.34 | +0.10 | buy |
| UBS Group AG | 271,736 | 202,385 | -69,351 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 364,889 | 193,800 | -171,089 | 0.05 | 0.04 | -0.01 | sell |
| Longaeva Partners L.P. | 0 | 183,691 | +183,691 | 0.00 | 0.13 | +0.13 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 343,667 | 173,740 | -169,927 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 381,535 | 168,473 | -213,062 | 0.04 | 0.02 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 159,751 | 149,626 | -10,125 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 149,445 | +149,445 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 240,457 | 144,111 | -96,346 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 142,761 | 144,107 | +1,346 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 144,927 | 143,708 | -1,219 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 269,655 | 140,295 | -129,360 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 158,753 | 138,705 | -20,048 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 0 | 114,400 | +114,400 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 162,501 | 109,731 | -52,770 | 0.03 | 0.02 | -0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 105,960 | +105,960 | 0.00 | 0.05 | +0.05 | buy |
| Bleichroeder LP | 0 | 100,000 | +100,000 | 0.00 | 0.25 | +0.25 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 95,417 | +95,417 | 0.00 | 0.03 | +0.03 | buy |
| Cinctive Capital Management LP | 0 | 94,444 | +94,444 | 0.00 | 0.09 | +0.09 | buy |
| Qube Research & Technologies Ltd | 119,292 | 90,316 | -28,976 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,822 | 75,310 | +58,488 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 48,001 | 72,282 | +24,281 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 61,671 | 69,485 | +7,814 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 48,051 | 67,656 | +19,605 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 67,240 | 67,516 | +276 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 69,343 | 66,288 | -3,055 | 0.01 | 0.01 | +0.00 | sell |
| Mariner, LLC | 49,131 | 62,718 | +13,587 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 62,421 | +62,421 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 36,964 | 62,421 | +25,457 | 0.03 | 0.06 | +0.03 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.13 | +0.13 | buy |
| Creative Planning | 39,890 | 59,974 | +20,084 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 59,484 | +59,484 | 0.00 | 0.60 | +0.60 | buy |
| Swiss National Bank | 58,300 | 58,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 47,266 | 51,491 | +4,225 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 50,000 | 50,000 | 0 | 0.04 | 0.04 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 47,630 | 47,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,822 | 47,377 | +7,555 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 27,303 | 43,339 | +16,036 | 0.02 | 0.04 | +0.01 | buy |
| HRT FINANCIAL LP | 84,067 | 38,586 | -45,481 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 23,282 | 31,251 | +7,969 | 0.01 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 30,816 | 30,816 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,799 | 30,397 | -402 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28,659 | 30,151 | +1,492 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 39,451 | 29,543 | -9,908 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 10,128 | 28,988 | +18,860 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 0 | 28,158 | +28,158 | 0.00 | 0.20 | +0.20 | buy |
| Corient Private Wealth LLC | 0 | 27,885 | +27,885 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 27,736 | +27,736 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 121,257 | 26,324 | -94,933 | 0.03 | 0.01 | -0.03 | sell |
| Knott David M Jr | 0 | 24,200 | +24,200 | 0.00 | 0.20 | +0.20 | buy |
| Voleon Capital Management LP | 49,663 | 24,092 | -25,571 | 0.01 | 0.01 | -0.00 | sell |
| Brevan Howard Capital Management LP | 10,970 | 24,078 | +13,108 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 22,318 | 22,875 | +557 | 0.06 | 0.09 | +0.03 | buy |
| JANE STREET GROUP, LLC | 186,844 | 22,812 | -164,032 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 60,514 | 20,939 | -39,575 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.12 | 0.16 | +0.04 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,909 | 19,067 | +9,158 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 28,628 | 18,701 | -9,927 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 13,253 | 17,631 | +4,378 | 0.00 | 0.01 | +0.00 | buy |