| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 3,196,701 | 5,750,683 | +2,553,982 | 1.50 | 2.81 | +1.31 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,138,531 | 3,280,237 | +2,141,706 | 0.34 | 0.95 | +0.61 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000 | 2,232,829 | +1,282,829 | 0.03 | 0.07 | +0.04 | buy |
| ORBIMED ADVISORS LLC | 517,606 | 1,147,655 | +630,049 | 0.16 | 0.40 | +0.24 | buy |
| TANG CAPITAL MANAGEMENT LLC | 571,138 | 921,138 | +350,000 | 1.01 | 1.64 | +0.62 | buy |
| Paradigm Biocapital Advisors LP | 1,348,015 | 1,542,805 | +194,790 | 0.81 | 1.03 | +0.22 | buy |
| PFM Health Sciences, LP | 255,967 | 296,036 | +40,069 | 0.21 | 0.26 | +0.05 | buy |
| ALGERT GLOBAL LLC | 79,680 | 39,884 | +39,796 | 0.05 | 0.02 | 0.00 | sell |
| NEOS Investment Management LLC | 16,388 | 24,023 | +7,635 | 0.02 | 0.02 | -0.00 | buy |
| Rafferty Asset Management, LLC | 97,055 | 104,651 | +7,596 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 258,588 | 263,817 | +5,229 | 0.55 | 0.53 | -0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 12,540 | 17,481 | +4,941 | 0.03 | 0.02 | -0.00 | buy |
| PROFUND ADVISORS LLC | 15,263 | 19,352 | +4,089 | 0.01 | 0.01 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 59,352 | 61,975 | +2,623 | 0.07 | 0.07 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,996 | 6,771 | -2,225 | 0.02 | 0.02 | -0.00 | sell |
| Birchview Capital, LP | 25,114 | 20,000 | -5,114 | 0.35 | 0.32 | -0.03 | sell |
| VIRTUS ADVISERS, LLC | 10,181 | 4,153 | -6,028 | 0.09 | 0.04 | -0.06 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 18,579 | 11,491 | -7,088 | 0.05 | 0.03 | -0.02 | sell |
| Nebula Research & Development LLC | 24,653 | 13,125 | -11,528 | 0.09 | 0.04 | -0.05 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 42,529 | 14,022 | -28,507 | 0.01 | 0.01 | -0.01 | sell |
| Blue Owl Capital Holdings LP | 2,924,842 | 2,049,172 | -875,670 | 9.96 | 9.94 | -0.02 | sell |
| BRAIDWELL LP | 1,240,865 | 176,173 | -1,064,692 | 0.68 | 0.10 | -0.59 | sell |