| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 3,196,701 | 5,750,683 | +2,553,982 | 1.50 | 2.81 | +1.31 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,138,531 | 3,280,237 | +2,141,706 | 0.34 | 0.95 | +0.61 | buy |
| ALLIANCEBERNSTEIN L.P. | 33,200 | 1,728,545 | +1,695,345 | 0.00 | 0.01 | +0.01 | buy |
| Avidity Partners Management LP | 0 | 1,559,826 | +1,559,826 | 0.00 | 1.16 | +1.16 | buy |
| VR Adviser, LLC | 0 | 1,379,965 | +1,379,965 | 0.00 | 1.53 | +1.53 | buy |
| Holocene Advisors, LP | 0 | 1,316,005 | +1,316,005 | 0.00 | 0.10 | +0.10 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000 | 2,232,829 | +1,282,829 | 0.03 | 0.07 | +0.04 | buy |
| MARSHALL WACE, LLP | 47,044 | 1,184,037 | +1,136,993 | 0.00 | 0.03 | +0.03 | buy |
| Cormorant Asset Management, LP | 0 | 1,125,000 | +1,125,000 | 0.00 | 1.14 | +1.14 | buy |
| VANGUARD GROUP INC | 1,774,345 | 2,871,375 | +1,097,030 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 0 | 1,057,949 | +1,057,949 | 0.00 | 0.47 | +0.47 | buy |
| RTW INVESTMENTS, LP | 0 | 1,052,630 | +1,052,630 | 0.00 | 0.28 | +0.28 | buy |
| CITADEL ADVISORS LLC | 1,109,171 | 1,943,139 | +833,968 | 0.02 | 0.03 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 749,916 | +749,916 | 0.00 | 0.32 | +0.32 | buy |
| Rock Springs Capital Management LP | 0 | 658,338 | +658,338 | 0.00 | 0.35 | +0.35 | buy |
| Foresite Capital Management V, LLC | 0 | 657,905 | +657,905 | 0.00 | 7.33 | +7.33 | buy |
| ORBIMED ADVISORS LLC | 517,606 | 1,147,655 | +630,049 | 0.16 | 0.40 | +0.24 | buy |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 0 | 595,489 | +595,489 | 0.00 | 1.66 | +1.66 | buy |
| STATE STREET CORP | 1,425,459 | 1,941,188 | +515,729 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 377,323 | +377,323 | 0.00 | 2.38 | +2.38 | buy |
| TANG CAPITAL MANAGEMENT LLC | 571,138 | 921,138 | +350,000 | 1.01 | 1.64 | +0.62 | buy |
| CenterBook Partners LP | 0 | 341,262 | +341,262 | 0.00 | 0.37 | +0.37 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 677,330 | 976,486 | +299,156 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 169,367 | 452,787 | +283,420 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 131,349 | 412,745 | +281,396 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,348,015 | 1,542,805 | +194,790 | 0.81 | 1.03 | +0.22 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 163,047 | +163,047 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 40,192 | 197,314 | +157,122 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 61,621 | 212,448 | +150,827 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 150,708 | +150,708 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 148,773 | +148,773 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 114,195 | +114,195 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 257,873 | 370,631 | +112,758 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 321,100 | 421,708 | +100,608 | 0.01 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 98,296 | +98,296 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 92,869 | +92,869 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 21,004 | 96,596 | +75,592 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 115,112 | 190,520 | +75,408 | 0.00 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 9,936 | 85,172 | +75,236 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 0 | 74,827 | +74,827 | 0.00 | 0.07 | +0.07 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 68,534 | +68,534 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 57,361 | +57,361 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 53,261 | +53,261 | 0.00 | 0.19 | +0.19 | buy |
| Bank of New York Mellon Corp | 94,240 | 137,997 | +43,757 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 95,771 | 136,887 | +41,116 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 255,967 | 296,036 | +40,069 | 0.22 | 0.28 | +0.06 | buy |
| Russell Investments Group, Ltd. | 0 | 34,293 | +34,293 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 263,949 | 296,852 | +32,903 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 46,300 | 73,600 | +27,300 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 25,976 | +25,976 | 0.00 | 0.08 | +0.08 | buy |
| Legal & General Group Plc | 19,561 | 39,251 | +19,690 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 57,178 | 76,018 | +18,840 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 18,528 | +18,528 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 18,026 | +18,026 | 0.00 | 0.02 | +0.02 | buy |
| Mariner, LLC | 0 | 16,354 | +16,354 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 21,690 | 37,462 | +15,772 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 12,969 | +12,969 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,752 | 36,656 | +12,904 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 12,164 | +12,164 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 0 | 10,669 | +10,669 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 10,460 | +10,460 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,337 | 22,726 | +9,389 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 46,702 | 54,351 | +7,649 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 16,388 | 24,023 | +7,635 | 0.02 | 0.02 | -0.00 | buy |
| Rafferty Asset Management, LLC | 97,055 | 104,651 | +7,596 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,510 | 15,818 | +6,308 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 549,276 | 555,067 | +5,791 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 258,588 | 263,817 | +5,229 | 0.72 | 0.72 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 12,540 | 17,481 | +4,941 | 0.03 | 0.02 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,200 | 13,892 | +4,692 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,782 | 15,175 | +4,393 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 15,263 | 19,352 | +4,089 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 19,470 | 23,268 | +3,798 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,125 | 8,883 | +3,758 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 68,358 | 72,098 | +3,740 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 325 | 4,024 | +3,699 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 2,847 | +2,847 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 59,352 | 61,975 | +2,623 | 0.03 | 0.03 | +0.00 | buy |
| STRS OHIO | 31,900 | 34,100 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 47,407 | 49,361 | +1,954 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 19,600 | 20,800 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,599 | 3,787 | +1,188 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 526 | 679 | +153 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 450 | 595 | +145 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 127 | 218 | +91 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 138 | 165 | +27 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 33 | 59 | +26 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 122 | 137 | +15 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 496 | 504 | +8 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 5 | +5 | 0.00 | 0.00 | 0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 36 | 36 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 451 | 451 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 20.95 | 20.73 | -0.23 | hold |
| Parallel Advisors, LLC | 1,317 | 1,317 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Washington Trust Advisors, Inc. | 127 | 127 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AMALGAMATED BANK | 896 | 896 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |