| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 9.95 | 9.98 | +0.03 | hold |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 1.77 | 1.55 | -0.23 | hold |
| Lynx1 Capital Management LP | 3,215,722 | 4,400,842 | +1,185,120 | 8.72 | 9.57 | +0.86 | buy |
| BlackRock, Inc. | 4,220,862 | 4,217,933 | -2,929 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,860,839 | 3,855,552 | -5,287 | 0.58 | 0.53 | -0.05 | sell |
| VANGUARD GROUP INC | 3,039,731 | 3,020,100 | -19,631 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 2,747,145 | 2,613,693 | -133,452 | 0.02 | 0.02 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 2,435,972 | 2,385,972 | -50,000 | 5.95 | 5.80 | -0.15 | sell |
| FRANKLIN RESOURCES INC | 2,219,761 | 2,228,160 | +8,399 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 2,338,629 | 2,095,998 | -242,631 | 1.51 | 1.70 | +0.18 | sell |
| ORBIMED ADVISORS LLC | 1,923,855 | 1,923,855 | 0 | 0.35 | 0.36 | +0.01 | hold |
| RTW INVESTMENTS, LP | 1,705,960 | 1,705,960 | 0 | 0.20 | 0.18 | -0.01 | hold |
| STATE STREET CORP | 1,752,679 | 1,607,592 | -145,087 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 0.89 | 0.78 | -0.11 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,241,817 | 1,279,496 | +37,679 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,303,221 | 1,276,538 | -26,683 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 1,193,410 | 1,193,410 | 0 | 0.51 | 0.47 | -0.04 | hold |
| Nextech Invest, Ltd. | 1,141,145 | 1,141,145 | 0 | 2.01 | 1.63 | -0.38 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,121,138 | 1,121,138 | 0 | 0.47 | 0.43 | -0.04 | hold |
| Patient Square Capital LP | 878,897 | 868,897 | -10,000 | 2.75 | 2.36 | -0.39 | sell |
| GOLDMAN SACHS GROUP INC | 648,957 | 702,138 | +53,181 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 644,633 | 668,233 | +23,600 | 0.28 | 0.31 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 524,385 | 661,285 | +136,900 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 567,999 | 626,581 | +58,582 | 0.01 | 0.01 | -0.00 | buy |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 0.70 | 0.63 | -0.07 | hold |
| Foresite Capital Management VI LLC | 634,558 | 594,025 | -40,533 | 2.63 | 2.51 | -0.12 | sell |
| DEUTSCHE BANK AG\ | 575,531 | 566,781 | -8,750 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 783,177 | 510,828 | -272,349 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 483,889 | 453,203 | -30,686 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 424,262 | 435,516 | +11,254 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 363,008 | 334,525 | -28,483 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 278,819 | 311,309 | +32,490 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 241,343 | 268,467 | +27,124 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 263,817 | 263,817 | 0 | 0.31 | 0.29 | -0.02 | hold |
| Voss Capital, LP | 175,000 | 251,717 | +76,717 | 0.10 | 0.13 | +0.03 | buy |
| MORGAN STANLEY | 481,832 | 242,092 | -239,740 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 221,430 | 215,580 | -5,850 | 0.04 | 0.03 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 161,057 | 186,083 | +25,026 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 188,030 | 180,685 | -7,345 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 175,427 | +175,427 | 0.00 | 0.12 | +0.12 | buy |
| Bank of New York Mellon Corp | 136,414 | 155,881 | +19,467 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 29,175 | 139,660 | +110,485 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,438 | 129,918 | +50,480 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 129,721 | 129,344 | -377 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 112,670 | 125,189 | +12,519 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 68,467 | 119,342 | +50,875 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 80,353 | 106,580 | +26,227 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 43,547 | 97,069 | +53,522 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 71,338 | 74,105 | +2,767 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 77,621 | 70,044 | -7,577 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 67,119 | +67,119 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 49,243 | 60,555 | +11,312 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 62,700 | 50,300 | -12,400 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 34,396 | 48,883 | +14,487 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,723,001 | 47,630 | -1,675,371 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 45,292 | +45,292 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 44,493 | 43,095 | -1,398 | 0.02 | 0.01 | -0.00 | sell |
| NEOS Investment Management LLC | 39,164 | 42,692 | +3,528 | 0.01 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 39,164 | 42,692 | +3,528 | 0.09 | 0.09 | -0.00 | buy |
| Creative Planning | 12,950 | 41,723 | +28,773 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 29,363 | 40,986 | +11,623 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 54,942 | 39,226 | -15,716 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 49,878 | 37,372 | -12,506 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,721 | 36,417 | +4,696 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 22,000 | 35,199 | +13,199 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,687 | 32,739 | +7,052 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 31,893 | 31,893 | 0 | 0.09 | 0.09 | -0.00 | hold |
| Nebula Research & Development LLC | 43,407 | 31,853 | -11,554 | 0.03 | 0.02 | -0.01 | sell |
| MetLife Investment Management, LLC | 31,454 | 31,454 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,251 | 31,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33,319 | 29,854 | -3,465 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 81,000 | 26,491 | -54,509 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 31,494 | 25,329 | -6,165 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 22,341 | +22,341 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 22,138 | +22,138 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 16,842 | 21,712 | +4,870 | 0.42 | 0.19 | -0.23 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 22,132 | 20,932 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 20,920 | +20,920 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.13 | 0.15 | +0.02 | hold |
| SIMPLEX TRADING, LLC | 3,598 | 19,557 | +15,959 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 29,505 | 19,277 | -10,228 | 0.01 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 40,599 | 19,227 | -21,372 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,999 | 19,029 | +30 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 42,808 | 18,858 | -23,950 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 0 | 18,726 | +18,726 | 0.00 | 0.04 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 0 | 18,124 | +18,124 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 16,268 | 17,008 | +740 | 0.04 | 0.04 | -0.00 | buy |
| Mariner, LLC | 12,167 | 16,490 | +4,323 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,152 | 16,152 | +6,000 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 15,008 | +15,008 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,160 | 14,699 | -461 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 14,397 | 14,661 | +264 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 35,200 | 13,988 | -21,212 | 0.00 | 0.00 | -0.00 | sell |
| Massar Capital Management, LP | 0 | 13,418 | +13,418 | 0.00 | 0.08 | +0.08 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,918 | 12,918 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ProShare Advisors LLC | 13,953 | 12,665 | -1,288 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 11,643 | 12,174 | +531 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,737 | 11,853 | +116 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 11,173 | +11,173 | 0.00 | 0.00 | +0.00 | buy |