| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 3,215,722 | 4,400,842 | +1,185,120 | 8.72 | 9.57 | +0.86 | buy |
| Caption Management, LLC | 0 | 175,427 | +175,427 | 0.00 | 0.12 | +0.12 | buy |
| BANK OF AMERICA CORP /DE/ | 524,385 | 661,285 | +136,900 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 29,175 | 139,660 | +110,485 | 0.00 | 0.01 | +0.00 | buy |
| Voss Capital, LP | 175,000 | 251,717 | +76,717 | 0.10 | 0.13 | +0.03 | buy |
| Qube Research & Technologies Ltd | 0 | 67,119 | +67,119 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 567,999 | 626,581 | +58,582 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 43,547 | 97,069 | +53,522 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 648,957 | 702,138 | +53,181 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 68,467 | 119,342 | +50,875 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,438 | 129,918 | +50,480 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 45,292 | +45,292 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,241,817 | 1,279,496 | +37,679 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 278,819 | 311,309 | +32,490 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 12,950 | 41,723 | +28,773 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 241,343 | 268,467 | +27,124 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 80,353 | 106,580 | +26,227 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 161,057 | 186,083 | +25,026 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 644,633 | 668,233 | +23,600 | 0.28 | 0.31 | +0.03 | buy |
| Man Group plc | 0 | 22,341 | +22,341 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 22,138 | +22,138 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 20,920 | +20,920 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 136,414 | 155,881 | +19,467 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 18,726 | +18,726 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 0 | 18,124 | +18,124 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 3,598 | 19,557 | +15,959 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 15,008 | +15,008 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 34,396 | 48,883 | +14,487 | 0.00 | 0.00 | +0.00 | buy |
| Massar Capital Management, LP | 0 | 13,418 | +13,418 | 0.00 | 0.08 | +0.08 | buy |
| Walleye Capital LLC | 22,000 | 35,199 | +13,199 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 112,670 | 125,189 | +12,519 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 29,363 | 40,986 | +11,623 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 49,243 | 60,555 | +11,312 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 424,262 | 435,516 | +11,254 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 11,173 | +11,173 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,129 | +11,129 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,219,761 | 2,228,160 | +8,399 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,687 | 32,739 | +7,052 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,152 | 16,152 | +6,000 | 0.01 | 0.01 | +0.00 | buy |
| Corton Capital Inc. | 16,842 | 21,712 | +4,870 | 0.42 | 0.19 | -0.23 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,721 | 36,417 | +4,696 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 12,167 | 16,490 | +4,323 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 39,164 | 42,692 | +3,528 | 0.01 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 39,164 | 42,692 | +3,528 | 0.09 | 0.09 | -0.00 | buy |
| RHUMBLINE ADVISERS | 71,338 | 74,105 | +2,767 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,659 | 8,182 | +2,523 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,559 | 3,812 | +1,253 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 146 | 1,377 | +1,231 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 73 | 1,120 | +1,047 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 16,268 | 17,008 | +740 | 0.04 | 0.04 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 401 | 1,113 | +712 | 0.00 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 11,643 | 12,174 | +531 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 436 | +436 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 1,013 | 1,365 | +352 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 351 | +351 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,974 | 2,280 | +306 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,397 | 14,661 | +264 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 100 | 280 | +180 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 232 | 389 | +157 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 21 | 145 | +124 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,737 | 11,853 | +116 | 0.01 | 0.01 | +0.00 | buy |
| MAI Capital Management | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 64 | +64 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,999 | 19,029 | +30 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 241 | 267 | +26 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 5 | 10 | +5 | 0.00 | 0.00 | 0.00 | buy |
| ORBIMED ADVISORS LLC | 1,923,855 | 1,923,855 | 0 | 0.35 | 0.36 | +0.01 | hold |
| Ameritas Investment Partners, Inc. | 5,240 | 5,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 1.77 | 1.55 | -0.23 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,251 | 31,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,121,138 | 1,121,138 | 0 | 0.47 | 0.43 | -0.04 | hold |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 31,893 | 31,893 | 0 | 0.09 | 0.09 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,641 | 7,641 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 0.70 | 0.63 | -0.07 | hold |
| Daiwa Securities Group Inc. | 218 | 218 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,705,960 | 1,705,960 | 0 | 0.20 | 0.18 | -0.01 | hold |
| MetLife Investment Management, LLC | 31,454 | 31,454 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Assenagon Asset Management S.A. | 10,062 | 10,062 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nextech Invest, Ltd. | 1,141,145 | 1,141,145 | 0 | 2.01 | 1.63 | -0.38 | hold |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 0.89 | 0.78 | -0.11 | hold |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.13 | 0.15 | +0.02 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 9.95 | 9.98 | +0.03 | hold |
| KLP KAPITALFORVALTNING AS | 6,800 | 6,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 263,817 | 263,817 | 0 | 0.31 | 0.29 | -0.02 | hold |
| SBI Securities Co., Ltd. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Washington Trust Advisors, Inc. | 127 | 127 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 1,193,410 | 1,193,410 | 0 | 0.51 | 0.47 | -0.04 | hold |
| Police & Firemen's Retirement System of New Jersey | 10,582 | 10,582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,491 | 1,491 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,150 | 1,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,918 | 12,918 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,768 | 1,768 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CoreCap Advisors, LLC | 29 | 0 | -29 | 0.00 | 0.00 | -0.00 | sell |
| MassMutual Private Wealth & Trust, FSB | 36 | 0 | -36 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |