| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 176,173 | 1,176,173 | +1,000,000 | 0.10 | 0.56 | +0.46 | buy |
| Paradigm Biocapital Advisors LP | 1,542,805 | 2,321,013 | +778,208 | 1.03 | 1.36 | +0.33 | buy |
| RTW INVESTMENTS, LP | 1,052,630 | 1,705,960 | +653,330 | 0.28 | 0.41 | +0.13 | buy |
| Holocene Advisors, LP | 1,316,005 | 1,533,579 | +217,574 | 0.10 | 0.10 | +0.01 | buy |
| Rock Springs Capital Management LP | 658,338 | 736,914 | +78,576 | 0.35 | 0.40 | +0.06 | buy |
| Nebula Research & Development LLC | 13,125 | 34,537 | +21,412 | 0.04 | 0.07 | +0.03 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 14,022 | 32,842 | +18,820 | 0.01 | 0.01 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 61,975 | 45,975 | +16,000 | 0.07 | 0.06 | 0.00 | sell |
| Rafferty Asset Management, LLC | 104,651 | 114,670 | +10,019 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,771 | 11,151 | +4,380 | 0.02 | 0.02 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 17,481 | 21,362 | +3,881 | 0.02 | 0.02 | 0.00 | buy |
| PROFUND ADVISORS LLC | 19,352 | 22,772 | +3,420 | 0.01 | 0.01 | 0.00 | buy |
| NEOS Investment Management LLC | 24,023 | 25,640 | +1,617 | 0.02 | 0.01 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 53,261 | 54,358 | +1,097 | 0.19 | 0.15 | -0.03 | buy |
| E Fund Management Co., Ltd. | 74,827 | 75,839 | +1,012 | 0.07 | 0.07 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 4,153 | 4,228 | +75 | 0.04 | 0.03 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,280,237 | 3,280,000 | -237 | 0.95 | 0.82 | -0.13 | sell |
| Blue Owl Capital Holdings LP | 2,049,172 | 2,010,972 | -38,200 | 9.94 | 6.53 | -3.41 | sell |
| CenterBook Partners LP | 341,262 | 298,666 | -42,596 | 0.37 | 0.31 | -0.06 | sell |
| ORBIMED ADVISORS LLC | 1,147,655 | 1,070,055 | -77,600 | 0.40 | 0.33 | -0.07 | sell |
| PFM Health Sciences, LP | 296,036 | 182,810 | -113,226 | 0.26 | 0.17 | -0.08 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,232,829 | 1,355,876 | -876,953 | 0.07 | 0.04 | -0.03 | sell |
| Avidity Partners Management LP | 1,559,826 | 425,000 | -1,134,826 | 1.16 | 0.36 | -0.79 | sell |