| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 20.73 | 19.21 | -1.52 | hold |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 2.81 | 2.82 | +0.01 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,280,237 | 3,280,000 | -237 | 0.95 | 0.82 | -0.13 | sell |
| VANGUARD GROUP INC | 2,871,375 | 2,998,714 | +127,339 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,941,188 | 2,337,222 | +396,034 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,542,805 | 2,321,013 | +778,208 | 1.03 | 1.36 | +0.33 | buy |
| FRANKLIN RESOURCES INC | 2,444,130 | 2,191,262 | -252,868 | 0.01 | 0.01 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 2,049,172 | 2,010,972 | -38,200 | 9.94 | 6.53 | -3.41 | sell |
| CITADEL ADVISORS LLC | 1,943,139 | 1,955,257 | +12,118 | 0.03 | 0.03 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,728,545 | 1,854,410 | +125,865 | 0.01 | 0.01 | -0.00 | buy |
| RTW INVESTMENTS, LP | 1,052,630 | 1,705,960 | +653,330 | 0.28 | 0.41 | +0.13 | buy |
| Holocene Advisors, LP | 1,316,005 | 1,533,579 | +217,574 | 0.10 | 0.10 | +0.01 | buy |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 1.53 | 1.21 | -0.32 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,232,829 | 1,355,876 | -876,953 | 0.07 | 0.04 | -0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 976,486 | 1,208,421 | +231,935 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 176,173 | 1,176,173 | +1,000,000 | 0.10 | 0.56 | +0.46 | buy |
| ORBIMED ADVISORS LLC | 1,147,655 | 1,070,055 | -77,600 | 0.40 | 0.33 | -0.07 | sell |
| MARSHALL WACE, LLP | 1,184,037 | 1,053,764 | -130,273 | 0.03 | 0.02 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 759,760 | 1,022,905 | +263,145 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 921,138 | 921,138 | 0 | 1.64 | 1.10 | -0.53 | hold |
| Patient Square Capital LP | 0 | 824,705 | +824,705 | 0.00 | 5.12 | +5.12 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 788,567 | +788,567 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 658,338 | 736,914 | +78,576 | 0.35 | 0.40 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 452,787 | 700,552 | +247,765 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 838,283 | 673,372 | -164,911 | 0.00 | 0.00 | -0.00 | sell |
| Foresite Capital Management V, LLC | 657,905 | 657,905 | 0 | 7.33 | 7.65 | +0.33 | hold |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 1.66 | 1.57 | -0.09 | hold |
| DEUTSCHE BANK AG\ | 555,067 | 560,873 | +5,806 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 296,852 | 470,885 | +174,033 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 1,559,826 | 425,000 | -1,134,826 | 1.16 | 0.36 | -0.79 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 370,631 | 423,959 | +53,328 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 403,878 | 417,508 | +13,630 | 0.00 | 0.00 | -0.00 | buy |
| Lynx1 Capital Management LP | 377,323 | 410,830 | +33,507 | 2.38 | 2.44 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 412,745 | 409,793 | -2,952 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 92,869 | 328,417 | +235,548 | 0.02 | 0.06 | +0.04 | buy |
| CenterBook Partners LP | 341,262 | 298,666 | -42,596 | 0.37 | 0.31 | -0.06 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 421,708 | 281,800 | -139,908 | 0.01 | 0.01 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 263,817 | 263,817 | 0 | 0.72 | 0.69 | -0.04 | hold |
| BARCLAYS PLC | 197,314 | 248,614 | +51,300 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 185,871 | +185,871 | 0.00 | 0.51 | +0.51 | buy |
| UBS Group AG | 159,980 | 185,553 | +25,573 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 296,036 | 182,810 | -113,226 | 0.28 | 0.18 | -0.11 | sell |
| Ensign Peak Advisors, Inc | 148,773 | 148,773 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 137,997 | 138,346 | +349 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 114,195 | 135,036 | +20,841 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 104,651 | 114,670 | +10,019 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 72,098 | 106,025 | +33,927 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 76,018 | 90,711 | +14,693 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 74,827 | 75,839 | +1,012 | 0.07 | 0.07 | -0.01 | buy |
| Swiss National Bank | 73,600 | 73,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 68,534 | 70,911 | +2,377 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 54,351 | 62,860 | +8,509 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 212,448 | 59,240 | -153,208 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 49,361 | 58,158 | +8,797 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 53,261 | 54,358 | +1,097 | 0.19 | 0.15 | -0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 61,975 | 45,975 | -16,000 | 0.03 | 0.02 | -0.01 | sell |
| Legal & General Group Plc | 39,251 | 41,493 | +2,242 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 39,884 | 39,884 | 0 | 0.02 | 0.02 | -0.01 | hold |
| CITIGROUP INC | 22,107 | 38,388 | +16,281 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 36,624 | +36,624 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,656 | 36,479 | -177 | 0.00 | 0.00 | -0.00 | sell |
| Nebula Research & Development LLC | 13,125 | 34,537 | +21,412 | 0.04 | 0.07 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,486 | 33,581 | +18,095 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 14,022 | 32,842 | +18,820 | 0.01 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,956 | 32,810 | +15,854 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 31,893 | +31,893 | 0.00 | 0.18 | +0.18 | buy |
| Squarepoint Ops LLC | 10,669 | 30,774 | +20,105 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 22,726 | 29,841 | +7,115 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 23,268 | 29,110 | +5,842 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 37,462 | 28,666 | -8,796 | 0.01 | 0.01 | -0.00 | sell |
| Corebridge Financial, Inc. | 20,796 | 27,660 | +6,864 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 16,247 | 26,384 | +10,137 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 24,023 | 25,640 | +1,617 | 0.02 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 20,799 | 25,569 | +4,770 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,175 | 25,538 | +10,363 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 18,026 | 25,369 | +7,343 | 0.02 | 0.03 | +0.01 | buy |
| Caption Management, LLC | 0 | 23,000 | +23,000 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 57,361 | 22,944 | -34,417 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 19,352 | 22,772 | +3,420 | 0.01 | 0.01 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 17,481 | 21,362 | +3,881 | 0.02 | 0.02 | -0.01 | buy |
| JANE STREET GROUP, LLC | 96,596 | 21,155 | -75,441 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 20,840 | +20,840 | 0.00 | 0.31 | +0.31 | buy |
| AlphaQuest LLC | 2,039 | 20,404 | +18,365 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 679 | 20,360 | +19,681 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.32 | 0.29 | -0.03 | hold |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 20,800 | 17,900 | -2,900 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 17,487 | +17,487 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,892 | 16,808 | +2,916 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,969 | 16,010 | +3,041 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 16,354 | 15,490 | -864 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 85,172 | 15,057 | -70,115 | 0.01 | 0.00 | -0.01 | sell |
| Long Corridor Asset Management Ltd | 0 | 15,000 | +15,000 | 0.00 | 0.22 | +0.22 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,604 | 14,604 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ProShare Advisors LLC | 0 | 13,202 | +13,202 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 12,245 | +12,245 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,771 | 11,151 | +4,380 | 0.02 | 0.02 | +0.00 | buy |
| Arizona State Retirement System | 10,460 | 10,788 | +328 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 12,852 | 9,891 | -2,961 | 0.01 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,818 | 9,718 | -6,100 | 0.00 | 0.00 | -0.00 | sell |