| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 9.98 | 7.42 | -2.55 | hold |
| Lynx1 Capital Management LP | 4,400,842 | 5,766,090 | +1,365,248 | 9.57 | 6.96 | -2.61 | buy |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 1.55 | 1.38 | -0.16 | hold |
| BlackRock, Inc. | 4,217,933 | 4,169,962 | -47,971 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 3,020,100 | 2,943,325 | -76,775 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,855,552 | 2,927,013 | -928,539 | 0.53 | 0.27 | -0.26 | sell |
| Blue Owl Capital Holdings LP | 2,385,972 | 2,510,972 | +125,000 | 5.80 | 4.62 | -1.18 | buy |
| Kynam Capital Management, LP | 2,095,998 | 2,302,172 | +206,174 | 1.70 | 1.02 | -0.68 | buy |
| CITADEL ADVISORS LLC | 2,613,693 | 1,984,407 | -629,286 | 0.02 | 0.01 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 1,923,855 | 1,923,855 | 0 | 0.36 | 0.27 | -0.09 | hold |
| RTW INVESTMENTS, LP | 1,705,960 | 1,705,960 | 0 | 0.18 | 0.12 | -0.06 | hold |
| STATE STREET CORP | 1,607,592 | 1,677,314 | +69,722 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 2,228,160 | 1,416,036 | -812,124 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 0.78 | 0.46 | -0.32 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,279,496 | 1,295,320 | +15,824 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 1,193,410 | 1,193,410 | 0 | 0.47 | 0.28 | -0.19 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,276,538 | 1,183,821 | -92,717 | 0.00 | 0.00 | -0.00 | sell |
| Nextech Invest, Ltd. | 1,141,145 | 1,141,145 | 0 | 1.63 | 1.03 | -0.60 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,121,138 | 1,121,138 | 0 | 0.43 | 0.26 | -0.17 | hold |
| GOLDMAN SACHS GROUP INC | 702,138 | 983,960 | +281,822 | 0.00 | 0.00 | -0.00 | buy |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 0.63 | 0.45 | -0.18 | hold |
| DEUTSCHE BANK AG\ | 566,781 | 571,738 | +4,957 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 661,285 | 557,189 | -104,096 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 510,828 | 550,471 | +39,643 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 334,525 | 529,408 | +194,883 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 453,203 | 447,267 | -5,936 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 435,516 | 402,638 | -32,878 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 242,092 | 400,154 | +158,062 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 48,883 | 300,885 | +252,002 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 626,581 | 295,442 | -331,139 | 0.01 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 263,817 | 263,817 | 0 | 0.29 | 0.15 | -0.15 | hold |
| BARCLAYS PLC | 268,467 | 251,110 | -17,357 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 215,580 | 236,092 | +20,512 | 0.03 | 0.02 | -0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 222,318 | +222,318 | 0.00 | 0.02 | +0.02 | buy |
| Voss Capital, LP | 251,717 | 221,473 | -30,244 | 0.13 | 0.08 | -0.06 | sell |
| Nuveen, LLC | 180,685 | 215,595 | +34,910 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 20,920 | 197,920 | +177,000 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 194,507 | +194,507 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 311,309 | 188,185 | -123,124 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 119,342 | 187,618 | +68,276 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 10,062 | 177,685 | +167,623 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 186,083 | 168,131 | -17,952 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 43,095 | 167,979 | +124,884 | 0.01 | 0.05 | +0.04 | buy |
| Qube Research & Technologies Ltd | 67,119 | 152,409 | +85,290 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 155,881 | 149,925 | -5,956 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 125,189 | 141,069 | +15,880 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 70,044 | 139,024 | +68,980 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 124,531 | +124,531 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 26,491 | 107,175 | +80,684 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 60,555 | 102,312 | +41,757 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 15,008 | 90,318 | +75,310 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 74,105 | 71,809 | -2,296 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 59,672 | +59,672 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 45,292 | 56,777 | +11,485 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 35,199 | 56,736 | +21,537 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 56,486 | +56,486 | 0.00 | 0.11 | +0.11 | buy |
| Engineers Gate Manager LP | 18,124 | 50,363 | +32,239 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 50,300 | 50,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quantinno Capital Management LP | 0 | 49,525 | +49,525 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,152 | 48,652 | +32,500 | 0.01 | 0.02 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 47,630 | 47,630 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 106,580 | 47,163 | -59,417 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 12,174 | 46,011 | +33,837 | 0.00 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 19,227 | 45,936 | +26,709 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 36,417 | 43,237 | +6,820 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 11,118 | 42,190 | +31,072 | 0.04 | 0.10 | +0.05 | buy |
| HRT FINANCIAL LP | 0 | 42,109 | +42,109 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 39,226 | 40,729 | +1,503 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 32,739 | 39,117 | +6,378 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 37,300 | +37,300 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 32,669 | +32,669 | 0.00 | 0.07 | +0.07 | buy |
| JPMORGAN CHASE & CO | 97,069 | 31,868 | -65,201 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,251 | 31,253 | +2 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 10,464 | 29,019 | +18,555 | 0.01 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 22,138 | 28,988 | +6,850 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 175,427 | 28,389 | -147,038 | 0.12 | 0.01 | -0.11 | sell |
| Mariner, LLC | 16,490 | 28,151 | +11,661 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 37,372 | 27,905 | -9,467 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 41,723 | 27,376 | -14,347 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 21,712 | 27,117 | +5,405 | 0.19 | 0.40 | +0.21 | buy |
| Magnetar Financial LLC | 0 | 26,263 | +26,263 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 19,277 | 26,234 | +6,957 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,854 | 25,988 | -3,866 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 25,329 | 25,619 | +290 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 31,454 | 23,245 | -8,209 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.15 | 0.09 | -0.06 | hold |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,029 | 17,826 | -1,203 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 15,528 | +15,528 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 18,858 | 15,295 | -3,563 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 10,582 | 14,996 | +4,414 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 0 | 14,615 | +14,615 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 13,942 | +13,942 | 0.00 | 0.00 | +0.00 | buy |
| Compass Ion Advisors, LLC | 0 | 13,904 | +13,904 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 19,557 | 13,285 | -6,272 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,918 | 12,918 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtus Investment Advisers, LLC | 10,506 | 12,714 | +2,208 | 0.03 | 0.02 | -0.01 | buy |
| Inscription Capital, LLC | 0 | 11,284 | +11,284 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 12,665 | 10,828 | -1,837 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 129,344 | 10,671 | -118,673 | 0.00 | 0.00 | -0.00 | sell |