| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Blue Owl Capital Holdings LP | 0 | 3,419,842 | +3,419,842 | 0.00 | 8.33 | +8.33 | buy |
| MORGAN STANLEY | 283,416 | 919,899 | +636,483 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 4,617 | 545,584 | +540,967 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,890,775 | 3,281,280 | +390,505 | 0.01 | 0.02 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.61 | +0.61 | buy |
| TANG CAPITAL MANAGEMENT LLC | 621,138 | 771,138 | +150,000 | 0.79 | 0.73 | -0.07 | buy |
| DIMENSIONAL FUND ADVISORS LP | 798,716 | 915,758 | +117,042 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 438,745 | 529,877 | +91,132 | 0.73 | 0.76 | +0.04 | buy |
| VANGUARD GROUP INC | 1,688,533 | 1,771,443 | +82,910 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,065,048 | 1,132,889 | +67,841 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 590,823 | 655,664 | +64,841 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 50,342 | +50,342 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 521,896 | 565,404 | +43,508 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 86,111 | 128,315 | +42,204 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 222,700 | 264,088 | +41,388 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 38,600 | +38,600 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 103,463 | 140,779 | +37,316 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 34,955 | +34,955 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 33,374 | +33,374 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 103,317 | 135,412 | +32,095 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 53,393 | 85,224 | +31,831 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 16,540 | 41,020 | +24,480 | 0.01 | 0.02 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 32,632 | 56,926 | +24,294 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 20,067 | +20,067 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 121,800 | 141,000 | +19,200 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 229,986 | 246,705 | +16,719 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 15,906 | +15,906 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 254,817 | 266,922 | +12,105 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 10,623 | +10,623 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,246 | +10,246 | 0.00 | 0.01 | +0.01 | buy |
| Vontobel Holding Ltd. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 39,702 | 48,919 | +9,217 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 38,600 | 46,300 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,402 | 22,022 | +7,620 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,947 | 19,964 | +7,017 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 6,846 | +6,846 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,544 | 17,844 | +5,300 | 0.01 | 0.02 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 35,565 | 40,125 | +4,560 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,921 | 25,201 | +4,280 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 10,266 | 14,463 | +4,197 | 0.02 | 0.03 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 1,095 | 4,954 | +3,859 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 10,507 | 14,076 | +3,569 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 8,404 | 10,879 | +2,475 | 0.05 | 0.07 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 90,570 | 92,875 | +2,305 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 2,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,959 | 8,027 | +2,068 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 97,159 | 99,003 | +1,844 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 12,862 | 14,449 | +1,587 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 1,317 | +1,317 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 1,235,592 | 1,236,564 | +972 | 0.07 | 0.05 | -0.02 | buy |
| JPMORGAN CHASE & CO | 24,314 | 25,193 | +879 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 504 | +504 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 45,239 | 45,730 | +491 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 604 | 858 | +254 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 241 | +241 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 18,591 | 18,718 | +127 | 0.03 | 0.03 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 14,071 | 14,135 | +64 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 544,848 | 544,848 | 0 | 0.11 | 0.11 | +0.01 | hold |
| Ameritas Investment Partners, Inc. | 1,984 | 1,984 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 3,196,701 | 3,196,701 | 0 | 0.78 | 0.82 | +0.04 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,542 | 6,542 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 127,284 | 127,284 | 0 | 0.36 | 0.31 | -0.05 | hold |
| Hudson Bay Capital Management LP | 225,000 | 225,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Daiwa Securities Group Inc. | 127 | 127 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 13,337 | 13,337 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Birchview Capital, LP | 25,114 | 25,114 | 0 | 0.19 | 0.20 | +0.01 | hold |
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 18.48 | 18.23 | -0.24 | hold |
| Rubric Capital Management LP | 626,929 | 626,929 | 0 | 0.24 | 0.24 | -0.00 | hold |
| Annandale Capital, LLC | 12,000 | 12,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Washington Trust Advisors, Inc. | 127 | 127 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 20,959 | 20,959 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,286 | 1,286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 14,009 | 14,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 122 | 122 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,692 | 10,692 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 42,529 | 42,529 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 141 | 117 | -24 | 0.00 | 0.00 | -0.00 | sell |
| Capital Advisors, Ltd. LLC | 37 | 0 | -37 | 0.00 | 0.00 | 0.00 | sell |
| Baker Avenue Asset Management, LP | 48 | 0 | -48 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 21,875 | 21,816 | -59 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,757 | 6,686 | -71 | 0.00 | 0.00 | +0.00 | sell |
| Covestor Ltd | 123 | 0 | -123 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 10,873 | 10,692 | -181 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 229 | 29 | -200 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 224 | 0 | -224 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,437 | 2,170 | -267 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 43,740 | 43,380 | -360 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 1,041 | 511 | -530 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 10,754 | 10,061 | -693 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 34,804 | 33,759 | -1,045 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,574 | 442 | -1,132 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 15,390 | 10,234 | -5,156 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Middle East FZE | 7,019 | 1,195 | -5,824 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 35,759 | 29,637 | -6,122 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 239,725 | 233,366 | -6,359 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 7,095 | 0 | -7,095 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 62,608 | 54,921 | -7,687 | 0.00 | 0.00 | -0.00 | sell |