| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 19.21 | 13.23 | -5.98 | hold |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 2.82 | 2.37 | -0.44 | hold |
| BlackRock, Inc. | 4,338,725 | 4,371,025 | +32,300 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,280,000 | 3,379,399 | +99,399 | 0.82 | 0.78 | -0.04 | buy |
| VANGUARD GROUP INC | 2,998,714 | 2,936,227 | -62,487 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,955,257 | 2,682,904 | +727,647 | 0.03 | 0.03 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 2,010,972 | 2,370,972 | +360,000 | 6.53 | 6.65 | +0.13 | buy |
| FRANKLIN RESOURCES INC | 2,191,262 | 2,199,709 | +8,447 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 2,337,222 | 2,124,484 | -212,738 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,854,410 | 2,011,525 | +157,115 | 0.01 | 0.01 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 1,070,055 | 1,942,555 | +872,500 | 0.33 | 0.49 | +0.16 | buy |
| RTW INVESTMENTS, LP | 1,705,960 | 1,705,960 | 0 | 0.41 | 0.31 | -0.10 | hold |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 1.21 | 1.15 | -0.06 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,022,905 | 1,318,372 | +295,467 | 0.00 | 0.00 | -0.00 | buy |
| Lynx1 Capital Management LP | 410,830 | 1,257,795 | +846,965 | 2.44 | 5.74 | +3.31 | buy |
| Kynam Capital Management, LP | 0 | 1,252,738 | +1,252,738 | 0.00 | 1.01 | +1.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,208,421 | 1,214,641 | +6,220 | 0.00 | 0.00 | -0.00 | buy |
| Siren, L.L.C. | 1,211,357 | 1,211,357 | 0 | 1.01 | 0.65 | -0.36 | hold |
| BRAIDWELL LP | 1,176,173 | 1,176,173 | 0 | 0.56 | 0.42 | -0.13 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,355,876 | 1,030,438 | -325,438 | 0.04 | 0.02 | -0.02 | sell |
| TANG CAPITAL MANAGEMENT LLC | 921,138 | 921,138 | 0 | 1.10 | 0.74 | -0.36 | hold |
| Patient Square Capital LP | 824,705 | 878,897 | +54,192 | 5.12 | 4.00 | -1.12 | buy |
| MILLENNIUM MANAGEMENT LLC | 788,567 | 833,962 | +45,395 | 0.01 | 0.01 | -0.00 | buy |
| Rock Springs Capital Management LP | 736,914 | 742,114 | +5,200 | 0.40 | 0.34 | -0.06 | buy |
| GOLDMAN SACHS GROUP INC | 700,552 | 685,374 | -15,178 | 0.00 | 0.00 | -0.00 | sell |
| Foresite Capital Management V, LLC | 657,905 | 657,905 | 0 | 7.65 | 6.67 | -0.99 | hold |
| MARSHALL WACE, LLP | 1,053,764 | 651,693 | -402,071 | 0.02 | 0.01 | -0.01 | sell |
| MORGAN STANLEY | 673,372 | 638,069 | -35,303 | 0.00 | 0.00 | -0.00 | sell |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 1.57 | 1.07 | -0.50 | hold |
| DEUTSCHE BANK AG\ | 560,873 | 580,136 | +19,263 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 417,508 | 504,264 | +86,756 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 470,885 | 500,908 | +30,023 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 423,959 | 430,971 | +7,012 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 263,817 | 263,817 | 0 | 0.69 | 0.50 | -0.18 | hold |
| BARCLAYS PLC | 248,614 | 245,231 | -3,383 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 185,553 | 235,713 | +50,160 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 185,871 | 205,000 | +19,129 | 0.51 | 0.46 | -0.05 | buy |
| JPMORGAN CHASE & CO | 29,110 | 198,214 | +169,104 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 281,800 | 190,508 | -91,292 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 0 | 167,315 | +167,315 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 328,417 | 156,497 | -171,920 | 0.06 | 0.02 | -0.04 | sell |
| BANK OF AMERICA CORP /DE/ | 409,793 | 155,270 | -254,523 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 138,346 | 137,616 | -730 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 135,036 | 133,260 | -1,776 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 106,025 | 132,976 | +26,951 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 130,647 | +130,647 | 0.00 | 0.03 | +0.03 | buy |
| Voss Capital, LP | 0 | 122,361 | +122,361 | 0.00 | 0.11 | +0.11 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 115,000 | +115,000 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 111,049 | +111,049 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 90,711 | 100,721 | +10,010 | 0.00 | 0.00 | -0.00 | buy |
| BIT Capital GmbH | 0 | 94,344 | +94,344 | 0.00 | 0.10 | +0.10 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 70,911 | 91,792 | +20,881 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 114,670 | 89,658 | -25,012 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 38,388 | 80,673 | +42,285 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 75,839 | 74,843 | -996 | 0.07 | 0.05 | -0.02 | sell |
| RHUMBLINE ADVISERS | 62,860 | 68,208 | +5,348 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 28,666 | 66,135 | +37,469 | 0.01 | 0.02 | +0.01 | buy |
| Swiss National Bank | 73,600 | 62,700 | -10,900 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 58,158 | 59,553 | +1,395 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 45,975 | 56,095 | +10,120 | 0.02 | 0.02 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 59,240 | 48,932 | -10,308 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 298,666 | 43,987 | -254,679 | 0.31 | 0.03 | -0.28 | sell |
| Nebula Research & Development LLC | 34,537 | 43,702 | +9,165 | 0.07 | 0.06 | -0.01 | buy |
| XTX Topco Ltd | 0 | 43,399 | +43,399 | 0.00 | 0.04 | +0.04 | buy |
| ALGERT GLOBAL LLC | 39,884 | 43,292 | +3,408 | 0.02 | 0.01 | -0.01 | buy |
| Legal & General Group Plc | 41,493 | 42,808 | +1,315 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 20,360 | 42,792 | +22,432 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 22,944 | 42,205 | +19,261 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 32,842 | 38,545 | +5,703 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,581 | 35,736 | +2,155 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 15,490 | 34,901 | +19,411 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,810 | 32,983 | +173 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 29,841 | 32,058 | +2,217 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 31,893 | 31,893 | 0 | 0.18 | 0.14 | -0.04 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 17,487 | 31,782 | +14,295 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,479 | 31,251 | -5,228 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 21,362 | 30,747 | +9,385 | 0.02 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,569 | 29,493 | +3,924 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 25,640 | 28,433 | +2,793 | 0.01 | 0.01 | -0.00 | buy |
| Corebridge Financial, Inc. | 27,660 | 25,719 | -1,941 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 16,808 | 24,864 | +8,056 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,538 | 24,825 | -713 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 23,500 | +23,500 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 15,057 | 23,201 | +8,144 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 17,900 | 21,900 | +4,000 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 20,273 | +20,273 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.29 | 0.20 | -0.09 | hold |
| Squarepoint Ops LLC | 30,774 | 19,101 | -11,673 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,384 | 18,657 | -7,727 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PROFUND ADVISORS LLC | 22,772 | 17,619 | -5,153 | 0.01 | 0.01 | -0.01 | sell |
| ProShare Advisors LLC | 13,202 | 17,326 | +4,124 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,010 | 15,277 | -733 | 0.00 | 0.00 | -0.00 | sell |
| Long Corridor Asset Management Ltd | 15,000 | 15,000 | 0 | 0.22 | 0.14 | -0.08 | hold |
| Brevan Howard Capital Management LP | 0 | 14,735 | +14,735 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 14,657 | +14,657 | 0.00 | 0.08 | +0.08 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,604 | 14,504 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 13,609 | +13,609 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,718 | 12,918 | +3,200 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,151 | 12,346 | +1,195 | 0.02 | 0.01 | -0.01 | buy |