| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 1,070,055 | 1,942,555 | +872,500 | 0.33 | 0.49 | +0.16 | buy |
| Lynx1 Capital Management LP | 410,830 | 1,257,795 | +846,965 | 2.44 | 5.74 | +3.31 | buy |
| Blue Owl Capital Holdings LP | 2,010,972 | 2,370,972 | +360,000 | 6.53 | 6.65 | +0.13 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,280,000 | 3,379,399 | +99,399 | 0.82 | 0.78 | -0.04 | buy |
| Patient Square Capital LP | 824,705 | 878,897 | +54,192 | 5.12 | 4.00 | -1.12 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 185,871 | 205,000 | +19,129 | 0.50 | 0.45 | -0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 45,975 | 56,095 | +10,120 | 0.06 | 0.05 | 0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 21,362 | 30,747 | +9,385 | 0.02 | 0.02 | 0.00 | buy |
| Nebula Research & Development LLC | 34,537 | 43,702 | +9,165 | 0.07 | 0.06 | -0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 32,842 | 38,545 | +5,703 | 0.01 | 0.01 | -0.00 | buy |
| Rock Springs Capital Management LP | 736,914 | 742,114 | +5,200 | 0.40 | 0.34 | -0.06 | buy |
| PROFUND ADVISORS LLC | 22,772 | 17,619 | +5,153 | 0.01 | 0.01 | 0.00 | sell |
| ALGERT GLOBAL LLC | 39,884 | 43,292 | +3,408 | 0.02 | 0.01 | 0.00 | buy |
| NEOS Investment Management LLC | 25,640 | 28,433 | +2,793 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,228 | 5,828 | +1,600 | 0.03 | 0.03 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,151 | 12,346 | +1,195 | 0.02 | 0.01 | -0.01 | buy |
| E Fund Management Co., Ltd. | 75,839 | 74,843 | -996 | 0.07 | 0.05 | -0.02 | sell |
| Rafferty Asset Management, LLC | 114,670 | 89,658 | -25,012 | 0.01 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 298,666 | 43,987 | -254,679 | 0.31 | 0.03 | -0.28 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,355,876 | 1,030,438 | -325,438 | 0.04 | 0.02 | -0.02 | sell |