| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 0 | 1,252,738 | +1,252,738 | 0.00 | 1.01 | +1.01 | buy |
| ORBIMED ADVISORS LLC | 1,070,055 | 1,942,555 | +872,500 | 0.33 | 0.49 | +0.16 | buy |
| Lynx1 Capital Management LP | 410,830 | 1,257,795 | +846,965 | 2.44 | 5.74 | +3.31 | buy |
| CITADEL ADVISORS LLC | 1,955,257 | 2,682,904 | +727,647 | 0.03 | 0.03 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 2,010,972 | 2,370,972 | +360,000 | 6.53 | 6.65 | +0.13 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,022,905 | 1,318,372 | +295,467 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 29,110 | 198,214 | +169,104 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 167,315 | +167,315 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,854,410 | 2,011,525 | +157,115 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 130,647 | +130,647 | 0.00 | 0.03 | +0.03 | buy |
| Voss Capital, LP | 0 | 122,361 | +122,361 | 0.00 | 0.11 | +0.11 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 115,000 | +115,000 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 111,049 | +111,049 | 0.00 | 0.03 | +0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,280,000 | 3,379,399 | +99,399 | 0.82 | 0.78 | -0.04 | buy |
| BIT Capital GmbH | 0 | 94,344 | +94,344 | 0.00 | 0.10 | +0.10 | buy |
| AMERIPRISE FINANCIAL INC | 417,508 | 504,264 | +86,756 | 0.00 | 0.00 | -0.00 | buy |
| Patient Square Capital LP | 824,705 | 878,897 | +54,192 | 5.12 | 4.00 | -1.12 | buy |
| UBS Group AG | 185,553 | 235,713 | +50,160 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 788,567 | 833,962 | +45,395 | 0.01 | 0.01 | -0.00 | buy |
| XTX Topco Ltd | 0 | 43,399 | +43,399 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 38,388 | 80,673 | +42,285 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 28,666 | 66,135 | +37,469 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 4,338,725 | 4,371,025 | +32,300 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 470,885 | 500,908 | +30,023 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 106,025 | 132,976 | +26,951 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 23,500 | +23,500 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 20,360 | 42,792 | +22,432 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 70,911 | 91,792 | +20,881 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 20,273 | +20,273 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 15,490 | 34,901 | +19,411 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 560,873 | 580,136 | +19,263 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 22,944 | 42,205 | +19,261 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 185,871 | 205,000 | +19,129 | 0.51 | 0.46 | -0.05 | buy |
| Brevan Howard Capital Management LP | 0 | 14,735 | +14,735 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 14,657 | +14,657 | 0.00 | 0.08 | +0.08 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 17,487 | 31,782 | +14,295 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 13,609 | +13,609 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 11,944 | +11,944 | 0.00 | 0.08 | +0.08 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0 | 11,153 | +11,153 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 45,975 | 56,095 | +10,120 | 0.02 | 0.02 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 90,711 | 100,721 | +10,010 | 0.00 | 0.00 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 21,362 | 30,747 | +9,385 | 0.02 | 0.02 | +0.00 | buy |
| Nebula Research & Development LLC | 34,537 | 43,702 | +9,165 | 0.07 | 0.06 | -0.01 | buy |
| FRANKLIN RESOURCES INC | 2,191,262 | 2,199,709 | +8,447 | 0.01 | 0.01 | -0.00 | buy |
| SG Americas Securities, LLC | 15,057 | 23,201 | +8,144 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,808 | 24,864 | +8,056 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,721 | 8,800 | +7,079 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 423,959 | 430,971 | +7,012 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 6,357 | +6,357 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,208,421 | 1,214,641 | +6,220 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 5,986 | +5,986 | 0.00 | 0.01 | +0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 32,842 | 38,545 | +5,703 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 62,860 | 68,208 | +5,348 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 736,914 | 742,114 | +5,200 | 0.40 | 0.34 | -0.06 | buy |
| ProShare Advisors LLC | 13,202 | 17,326 | +4,124 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 17,900 | 21,900 | +4,000 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,569 | 29,493 | +3,924 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 39,884 | 43,292 | +3,408 | 0.02 | 0.01 | -0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,718 | 12,918 | +3,200 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 25,640 | 28,433 | +2,793 | 0.01 | 0.01 | -0.00 | buy |
| MetLife Investment Management, LLC | 29,841 | 32,058 | +2,217 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,581 | 35,736 | +2,155 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,228 | 5,828 | +1,600 | 0.03 | 0.03 | -0.00 | buy |
| FEDERATED HERMES, INC. | 2,277 | 3,802 | +1,525 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 58,158 | 59,553 | +1,395 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 41,493 | 42,808 | +1,315 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,151 | 12,346 | +1,195 | 0.02 | 0.01 | -0.01 | buy |
| BFSG, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 59 | 242 | +183 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,810 | 32,983 | +173 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 117 | 213 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 5 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,240 | 5,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 2.82 | 2.37 | -0.44 | hold |
| MassMutual Private Wealth & Trust, FSB | 36 | 36 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 921,138 | 921,138 | 0 | 1.10 | 0.74 | -0.36 | hold |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 31,893 | 31,893 | 0 | 0.18 | 0.14 | -0.04 | hold |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 1.57 | 1.07 | -0.50 | hold |
| SIGNATUREFD, LLC | 451 | 451 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 9,891 | 9,891 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 218 | 218 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,705,960 | 1,705,960 | 0 | 0.41 | 0.31 | -0.10 | hold |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 1.21 | 1.15 | -0.06 | hold |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.29 | 0.20 | -0.09 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 19.21 | 13.23 | -5.98 | hold |
| Parallel Advisors, LLC | 1,317 | 1,317 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 263,817 | 263,817 | 0 | 0.69 | 0.50 | -0.18 | hold |
| Foresite Capital Management V, LLC | 657,905 | 657,905 | 0 | 7.65 | 6.67 | -0.99 | hold |
| Long Corridor Asset Management Ltd | 15,000 | 15,000 | 0 | 0.22 | 0.14 | -0.08 | hold |
| Washington Trust Advisors, Inc. | 127 | 127 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRAIDWELL LP | 1,176,173 | 1,176,173 | 0 | 0.56 | 0.42 | -0.13 | hold |
| Siren, L.L.C. | 1,211,357 | 1,211,357 | 0 | 1.01 | 0.65 | -0.36 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 1,150 | 1,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 137 | 137 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,768 | 1,768 | 0 | 0.00 | 0.00 | -0.00 | hold |