| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 5,766,090 | 8,963,500 | +3,197,410 | 6.96 | 18.78 | +11.82 | buy |
| Affinity Asset Advisors, LLC | 263,817 | 1,932,106 | +1,668,289 | 0.15 | 1.44 | +1.29 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 1,237,043 | +1,237,043 | 0.00 | 0.33 | +0.33 | buy |
| Kynam Capital Management, LP | 2,302,172 | 3,114,132 | +811,960 | 1.02 | 2.10 | +1.08 | buy |
| GREAT POINT PARTNERS LLC | 0 | 634,032 | +634,032 | 0.00 | 2.13 | +2.13 | buy |
| STATE STREET CORP | 1,677,314 | 2,197,338 | +520,024 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 59,672 | 470,526 | +410,854 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 400,154 | 766,934 | +366,780 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 215,595 | 579,095 | +363,500 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 360,162 | +360,162 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 2,943,325 | 3,298,504 | +355,179 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 343,667 | +343,667 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,169,962 | 4,400,296 | +230,334 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 227,003 | +227,003 | 0.00 | 0.24 | +0.24 | buy |
| Trexquant Investment LP | 187,618 | 381,535 | +193,917 | 0.01 | 0.04 | +0.02 | buy |
| Jump Financial, LLC | 194,507 | 364,889 | +170,382 | 0.02 | 0.05 | +0.03 | buy |
| CITIGROUP INC | 107,175 | 240,457 | +133,282 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 295,442 | 414,359 | +118,917 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 31,868 | 147,055 | +115,187 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 124,531 | 233,842 | +109,311 | 0.01 | 0.04 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 139,024 | 244,022 | +104,998 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 529,408 | 631,706 | +102,298 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 37,300 | 129,809 | +92,509 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 197,920 | 281,483 | +83,563 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 188,185 | 271,736 | +83,551 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 73,755 | +73,755 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| Voleon Capital Management LP | 0 | 49,663 | +49,663 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 42,109 | 84,067 | +41,958 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 39,822 | +39,822 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 37,519 | +37,519 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 36,964 | +36,964 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 402,638 | 436,273 | +33,635 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 30,487 | +30,487 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,671 | 39,451 | +28,780 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 2,782 | 30,923 | +28,141 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 102,312 | 130,323 | +28,011 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 27,303 | +27,303 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 0 | 23,282 | +23,282 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 39,117 | 60,514 | +21,397 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 28,151 | 49,131 | +20,980 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 40,729 | 61,671 | +20,942 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 4,272 | 24,409 | +20,137 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 50,363 | 69,343 | +18,980 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 251,110 | 269,655 | +18,545 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 16,638 | +16,638 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 571,738 | 586,636 | +14,898 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 15,295 | 28,628 | +13,333 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 27,376 | 39,890 | +12,514 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 12,403 | +12,403 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 12,714 | 22,318 | +9,604 | 0.02 | 0.06 | +0.04 | buy |
| Quarry LP | 0 | 9,600 | +9,600 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 50,300 | 58,300 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 23,245 | 30,816 | +7,571 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,295,320 | 1,302,262 | +6,942 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 15,528 | 21,204 | +5,676 | 0.01 | 0.03 | +0.02 | buy |
| SG Americas Securities, LLC | 10,466 | 15,631 | +5,165 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 14,615 | 19,318 | +4,703 | 0.01 | 0.03 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 43,237 | 47,187 | +3,950 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 968 | 4,598 | +3,630 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 523 | 4,130 | +3,607 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1,660 | 4,680 | +3,020 | 0.01 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,988 | 28,659 | +2,671 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,641 | 9,909 | +2,268 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 141,069 | 142,761 | +1,692 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,828 | 12,489 | +1,661 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,558 | 3,876 | +1,318 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 46,011 | 47,266 | +1,255 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 1,081 | +1,081 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,163 | 48,051 | +888 | 0.00 | 0.00 | +0.00 | buy |
| UMB Bank, n.a. | 0 | 685 | +685 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,284 | 2,871 | +587 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 483 | +483 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 137 | 560 | +423 | 0.00 | 0.00 | +0.00 | buy |
| Inscription Capital, LLC | 11,284 | 11,661 | +377 | 0.01 | 0.01 | +0.01 | buy |
| EverSource Wealth Advisors, LLC | 996 | 1,280 | +284 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 748 | 980 | +232 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 147 | 313 | +166 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 556 | 645 | +89 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 58 | +58 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 10 | 43 | +33 | 0.00 | 0.00 | 0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 27,905 | 27,937 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 1,873 | 1,895 | +22 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 30 | 33 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 5,750,683 | 5,750,683 | 0 | 1.38 | 2.00 | +0.62 | hold |
| MassMutual Private Wealth & Trust, FSB | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 47,630 | 47,630 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 18,528 | 18,528 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | 595,489 | 0 | 0.45 | 0.71 | +0.26 | hold |
| Daiwa Securities Group Inc. | 218 | 218 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 1,705,960 | 1,705,960 | 0 | 0.12 | 0.18 | +0.05 | hold |
| Nextech Invest, Ltd. | 1,141,145 | 1,141,145 | 0 | 1.03 | 1.14 | +0.11 | hold |
| VR Adviser, LLC | 1,379,965 | 1,379,965 | 0 | 0.46 | 0.71 | +0.24 | hold |
| Birchview Capital, LP | 20,000 | 20,000 | 0 | 0.09 | 0.12 | +0.03 | hold |
| Compass Ion Advisors, LLC | 13,904 | 13,904 | 0 | 0.01 | 0.01 | +0.01 | hold |
| MPM BioImpact LLC | 7,648,268 | 7,648,268 | 0 | 7.42 | 9.06 | +1.63 | hold |