| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,002,108 | 5,024,600 | -1,977,508 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 2,428,385 | 4,394,527 | +1,966,142 | 1.53 | 2.87 | +1.34 | buy |
| Frazier Life Sciences Management, L.P. | 2,142,855 | 4,142,855 | +2,000,000 | 1.05 | 2.40 | +1.35 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 4,000,000 | +4,000,000 | 0.00 | 0.20 | +0.20 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 3,604,096 | 3,704,096 | +100,000 | 0.22 | 0.28 | +0.06 | buy |
| Column Group LLC | 3,568,181 | 3,540,777 | -27,404 | 21.69 | 30.33 | +8.64 | sell |
| EcoR1 Capital, LLC | 3,418,068 | 3,418,068 | 0 | 0.82 | 1.19 | +0.38 | hold |
| VANGUARD GROUP INC | 2,252,519 | 2,882,055 | +629,536 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 1.84 | +1.84 | buy |
| STATE STREET CORP | 793,074 | 1,716,081 | +923,007 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 651,561 | 1,566,736 | +915,175 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 1,733,819 | 1,510,861 | -222,958 | 0.18 | 0.23 | +0.06 | sell |
| NEA Management Company, LLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 1.28 | +1.28 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,170,000 | 1,113,007 | -56,993 | 3.32 | 4.29 | +0.97 | sell |
| First Turn Management, LLC | 0 | 1,097,571 | +1,097,571 | 0.00 | 2.26 | +2.26 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,030,400 | +1,030,400 | 0.00 | 0.03 | +0.03 | buy |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 1.02 | 1.74 | +0.72 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 874,891 | 911,633 | +36,742 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 849,681 | 849,681 | 0 | 0.64 | 0.92 | +0.28 | hold |
| FRANKLIN RESOURCES INC | 750,516 | 750,516 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 369,222 | 494,168 | +124,946 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 421,000 | +421,000 | 0.00 | 0.51 | +0.51 | buy |
| Altium Capital Management LLC | 676,000 | 405,000 | -271,000 | 4.29 | 2.49 | -1.80 | sell |
| NORTHERN TRUST CORP | 353,197 | 353,341 | +144 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 480,331 | 300,823 | -179,508 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 522,968 | 287,100 | -235,868 | 0.10 | 0.07 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 219,943 | +219,943 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 80,800 | 208,600 | +127,800 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 105,690 | 201,122 | +95,432 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 196,852 | +196,852 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 183,494 | +183,494 | 0.00 | 0.26 | +0.26 | buy |
| GOLDMAN SACHS GROUP INC | 50,788 | 169,678 | +118,890 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 24,676 | 160,802 | +136,126 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 149,337 | +149,337 | 0.00 | 0.02 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 143,943 | 143,943 | 0 | 0.02 | 0.02 | +0.00 | hold |
| CITIGROUP INC | 6,563 | 133,906 | +127,343 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 280,000 | 130,000 | -150,000 | 0.99 | 0.79 | -0.20 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,831 | 121,926 | +74,095 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 118,679 | 115,090 | -3,589 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 72,397 | 111,973 | +39,576 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 111,146 | +111,146 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 188,500 | 110,900 | -77,600 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 105,010 | 109,009 | +3,999 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 108,624 | +108,624 | 0.00 | 0.13 | +0.13 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 106,601 | 104,544 | -2,057 | 0.00 | 0.00 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 103,992 | +103,992 | 0.00 | 0.93 | +0.93 | buy |
| Campbell & CO Investment Adviser LLC | 37,619 | 96,468 | +58,849 | 0.03 | 0.11 | +0.08 | buy |
| UBS Group AG | 40,973 | 94,061 | +53,088 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 262,956 | 92,366 | -170,590 | 0.08 | 0.04 | -0.04 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 126,030 | 88,540 | -37,490 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 49,550 | 73,167 | +23,617 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 83,926 | 71,405 | -12,521 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 57,904 | 60,300 | +2,396 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 53,043 | +53,043 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,570 | 44,714 | +35,144 | 0.00 | 0.00 | +0.00 | buy |
| Ratan Capital Management LP | 0 | 40,000 | +40,000 | 0.00 | 0.29 | +0.29 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 33,451 | +33,451 | 0.00 | 0.26 | +0.26 | buy |
| BARCLAYS PLC | 54,199 | 33,154 | -21,045 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 95,260 | 31,900 | -63,360 | 0.10 | 0.05 | -0.05 | sell |
| JPMORGAN CHASE & CO | 38,175 | 31,801 | -6,374 | 0.00 | 0.00 | +0.00 | sell |
| Atom Investors LP | 40,547 | 31,395 | -9,152 | 0.07 | 0.05 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 15,320 | 30,160 | +14,840 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 29,205 | +29,205 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 31,700 | 29,100 | -2,600 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 24,776 | 25,325 | +549 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 20,870 | 20,870 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 20,737 | 20,737 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NOMURA HOLDINGS INC | 0 | 20,512 | +20,512 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 19,401 | 19,236 | -165 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 17,686 | +17,686 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 26,056 | 17,371 | -8,685 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 0 | 16,372 | +16,372 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 13,431 | 15,217 | +1,786 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 14,146 | 14,298 | +152 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 0 | 13,744 | +13,744 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,457 | 13,029 | -3,428 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,305 | 12,922 | +6,617 | 0.01 | 0.02 | +0.01 | buy |
| Baird Financial Group, Inc. | 12,341 | 12,341 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 0 | 11,733 | +11,733 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 11,689 | +11,689 | 0.00 | 0.20 | +0.20 | buy |
| LPL Financial LLC | 10,000 | 10,290 | +290 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 10,085 | 9,437 | -648 | 0.06 | 0.07 | +0.01 | sell |
| SHELL ASSET MANAGEMENT CO | 0 | 8,965 | +8,965 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 7,900 | 7,400 | -500 | 0.00 | 0.00 | +0.00 | sell |
| Quantbot Technologies LP | 0 | 5,700 | +5,700 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,425 | 3,924 | -2,501 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 3,253 | 3,253 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,223 | 3,223 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AlphaQuest LLC | 0 | 2,938 | +2,938 | 0.00 | 0.01 | +0.01 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,149 | 2,149 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 1,964 | +1,964 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 3,405 | 1,316 | -2,089 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,255 | 750 | -8,505 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 574 | 574 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Pacer Advisors, Inc. | 0 | 516 | +516 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 274 | 274 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 0 | 249 | +249 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 118 | 118 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |