| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 2,142,855 | 4,142,855 | +2,000,000 | 1.05 | 2.40 | +1.35 | buy |
| VR Adviser, LLC | 2,428,385 | 4,394,527 | +1,966,142 | 1.53 | 2.87 | +1.34 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 262,956 | 92,366 | +170,590 | 0.18 | 0.09 | 0.00 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 3,604,096 | 3,704,096 | +100,000 | 0.07 | 0.09 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 6,305 | 12,922 | +6,617 | 0.01 | 0.02 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 10,085 | 9,437 | -648 | 0.06 | 0.07 | +0.01 | sell |
| Atom Investors LP | 40,547 | 31,395 | -9,152 | 0.07 | 0.05 | -0.01 | sell |
| Column Group LLC | 3,568,181 | 3,540,777 | -27,404 | 21.69 | 30.33 | +8.64 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,170,000 | 1,113,007 | -56,993 | 3.32 | 4.29 | +0.97 | sell |
| Monaco Asset Management SAM | 280,000 | 130,000 | -150,000 | 0.99 | 0.79 | -0.20 | sell |
| ArrowMark Colorado Holdings LLC | 1,733,819 | 1,510,861 | -222,958 | 0.18 | 0.23 | +0.06 | sell |
| ORBIMED ADVISORS LLC | 522,968 | 287,100 | -235,868 | 0.10 | 0.07 | -0.02 | sell |
| Altium Capital Management LLC | 676,000 | 405,000 | -271,000 | 4.29 | 2.49 | -1.80 | sell |