| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 4,431,008 | 6,572,700 | +2,141,692 | 0.12 | 0.12 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 1,399,514 | +1,399,514 | 0.00 | 1.34 | +1.34 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,178,300 | 2,060,240 | +881,940 | 2.13 | 2.40 | +0.28 | buy |
| Vivo Capital, LLC | 1,277,818 | 2,080,450 | +802,632 | 1.16 | 1.54 | +0.38 | buy |
| ORBIMED ADVISORS LLC | 0 | 700,000 | +700,000 | 0.00 | 0.09 | +0.09 | buy |
| NEA Management Company, LLC | 1,566,081 | 2,195,545 | +629,464 | 0.71 | 0.94 | +0.23 | buy |
| First Turn Management, LLC | 1,451,037 | 2,027,430 | +576,393 | 2.10 | 2.28 | +0.18 | buy |
| CITADEL ADVISORS LLC | 36,426 | 511,889 | +475,463 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 35,579 | 509,179 | +473,600 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,555,260 | 2,007,272 | +452,012 | 0.03 | 0.03 | -0.00 | buy |
| STATE STREET CORP | 1,846,262 | 2,196,549 | +350,287 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 5,113,034 | 5,435,087 | +322,053 | 0.00 | 0.00 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 255,000 | +255,000 | 0.00 | 0.06 | +0.06 | buy |
| DAFNA Capital Management LLC | 0 | 242,000 | +242,000 | 0.00 | 0.38 | +0.38 | buy |
| Parkman Healthcare Partners LLC | 0 | 203,006 | +203,006 | 0.00 | 0.13 | +0.13 | buy |
| CANTOR FITZGERALD, L. P. | 22,704 | 200,000 | +177,296 | 0.01 | 0.04 | +0.03 | buy |
| Nicholas Investment Partners, LP | 0 | 154,379 | +154,379 | 0.00 | 0.09 | +0.09 | buy |
| BANK OF AMERICA CORP /DE/ | 112,520 | 259,801 | +147,281 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 76,642 | 210,706 | +134,064 | 0.08 | 0.14 | +0.07 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 3,904,096 | 4,004,096 | +100,000 | 0.18 | 0.13 | -0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,062 | 126,681 | +95,619 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 76,093 | +76,093 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 950,522 | 1,022,790 | +72,268 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 53,870 | 107,432 | +53,562 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 97,500 | 150,260 | +52,760 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 49,530 | +49,530 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 20,275 | 69,036 | +48,761 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 47,695 | +47,695 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,295,025 | 1,332,860 | +37,835 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 36,158 | +36,158 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 35,300 | +35,300 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 35,285 | +35,285 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 71,794 | 104,106 | +32,312 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,212 | 40,782 | +28,570 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,278,713 | 1,305,991 | +27,278 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 27,634 | 53,983 | +26,349 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 51,392 | 77,424 | +26,032 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 270,006 | 294,784 | +24,778 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,229 | 38,486 | +22,257 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 20,000 | +20,000 | 0.00 | 0.09 | +0.09 | buy |
| Virtus Investment Advisers, LLC | 0 | 19,473 | +19,473 | 0.00 | 0.03 | +0.03 | buy |
| HSBC HOLDINGS PLC | 0 | 17,983 | +17,983 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 23,958 | 40,419 | +16,461 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 15,844 | +15,844 | 0.00 | 0.01 | +0.01 | buy |
| AlphaQuest LLC | 28,435 | 42,677 | +14,242 | 0.03 | 0.03 | -0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 13,662 | +13,662 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,467,809 | 2,480,420 | +12,611 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 3,203,789 | 3,215,887 | +12,098 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,713 | 40,766 | +12,053 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 717,188 | 727,830 | +10,642 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 0 | 10,088 | +10,088 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 10,061 | +10,061 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 62,400 | 68,400 | +6,000 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 10,818 | 16,469 | +5,651 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 147,800 | 152,700 | +4,900 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 107,862 | 112,628 | +4,766 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 74,929 | 79,538 | +4,609 | 0.00 | 0.00 | -0.00 | buy |
| ANTIPODES PARTNERS Ltd | 0 | 3,822 | +3,822 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,070 | 40,201 | +3,131 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 35,857 | 38,988 | +3,131 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 122 | 3,091 | +2,969 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 33,736 | 35,649 | +1,913 | 0.00 | 0.00 | -0.00 | buy |
| Clear Harbor Asset Management, LLC | 13,744 | 15,119 | +1,375 | 0.01 | 0.01 | -0.00 | buy |
| GAMMA Investing LLC | 149 | 707 | +558 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 549 | +549 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 350 | +350 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,482 | 1,807 | +325 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 0 | 294 | +294 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 178 | +178 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 146 | +146 | 0.00 | 0.00 | 0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 109 | +109 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 95 | 180 | +85 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 574 | 607 | +33 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,352 | 2,377 | +25 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 8,324 | 8,324 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,032 | 6,032 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,833 | 31,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 14,600 | 14,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jasper Ridge Partners, L.P. | 20,870 | 20,870 | 0 | 0.01 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 236 | 236 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 249 | 249 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 3,418,068 | 3,418,068 | 0 | 1.10 | 1.13 | +0.03 | hold |
| IFP Advisors, Inc | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Baird Financial Group, Inc. | 15,691 | 15,691 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 6,200 | 6,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 1.08 | 2.07 | +0.99 | hold |
| Commodore Capital LP | 2,000,000 | 2,000,000 | 0 | 1.18 | 0.82 | -0.36 | hold |
| Column Group LLC | 3,540,777 | 3,540,777 | 0 | 51.26 | 44.67 | -6.59 | hold |
| SBI Securities Co., Ltd. | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 1,007,575 | 1,007,575 | 0 | 0.36 | 0.32 | -0.04 | hold |
| Boxer Capital Management, LLC | 1,732,571 | 1,732,571 | 0 | 1.19 | 2.91 | +1.72 | hold |
| Federation des caisses Desjardins du Quebec | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 12,378 | 12,378 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFIZER INC | 5,376,344 | 5,376,344 | 0 | 1.67 | 5.99 | +4.32 | hold |
| AMALGAMATED BANK | 2,130 | 2,130 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,310 | 11,310 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 27 | 22 | -5 | 0.00 | 0.00 | -0.00 | sell |