| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 4,431,008 | 6,572,700 | +2,141,692 | 0.12 | 0.12 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,178,300 | 2,060,240 | +881,940 | 2.13 | 2.40 | +0.28 | buy |
| Vivo Capital, LLC | 1,277,818 | 2,080,450 | +802,632 | 1.16 | 1.54 | +0.38 | buy |
| NEA Management Company, LLC | 1,566,081 | 2,195,545 | +629,464 | 0.71 | 0.94 | +0.23 | buy |
| First Turn Management, LLC | 1,451,037 | 2,027,430 | +576,393 | 2.10 | 2.28 | +0.18 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,555,260 | 2,007,272 | +452,012 | 0.03 | 0.03 | 0.00 | buy |
| CANTOR FITZGERALD, L. P. | 22,704 | 200,000 | +177,296 | 0.00 | 0.02 | +0.02 | buy |
| Atom Investors LP | 76,642 | 210,706 | +134,064 | 0.08 | 0.14 | +0.07 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 174,846 | 47,642 | +127,204 | 0.11 | 0.02 | 0.00 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 3,904,096 | 4,004,096 | +100,000 | 0.06 | 0.05 | -0.02 | buy |
| Rafferty Asset Management, LLC | 51,392 | 77,424 | +26,032 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 28,435 | 42,677 | +14,242 | 0.03 | 0.03 | 0.00 | buy |
| PROFUND ADVISORS LLC | 10,818 | 16,469 | +5,651 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 13,744 | 15,119 | +1,375 | 0.01 | 0.01 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,482 | 1,807 | +325 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,963 | 14,247 | -716 | 0.01 | 0.01 | -0.00 | sell |
| NEOS Investment Management LLC | 45,476 | 40,934 | -4,542 | 0.01 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 45,476 | 40,934 | -4,542 | 0.15 | 0.07 | -0.08 | sell |
| Hennion & Walsh Asset Management, Inc. | 162,909 | 156,643 | -6,266 | 0.06 | 0.04 | -0.02 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 273,213 | 234,834 | -38,379 | 0.40 | 0.30 | -0.10 | sell |
| FRED ALGER MANAGEMENT, LLC | 219,276 | 178,722 | -40,554 | 0.01 | 0.01 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 1,395,352 | 1,346,189 | -49,163 | 0.15 | 0.12 | -0.03 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,580,745 | 819,194 | -761,551 | 11.20 | 5.45 | -5.75 | sell |
| VR Adviser, LLC | 4,394,527 | 3,182,527 | -1,212,000 | 2.43 | 1.51 | -0.92 | sell |
| Frazier Life Sciences Management, L.P. | 3,888,238 | 1,410,193 | -2,478,045 | 1.30 | 0.36 | -0.94 | sell |