| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nextech Invest, Ltd. | 7,162,637 | 7,162,637 | 0 | 5.66 | 6.39 | +0.72 | hold |
| EcoR1 Capital, LLC | 6,728,116 | 6,728,116 | 0 | 2.51 | 3.64 | +1.13 | hold |
| BlackRock, Inc. | 5,875,053 | 5,984,552 | +109,499 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 6,572,691 | 5,824,533 | -748,158 | 0.14 | 0.21 | +0.06 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,295,122 | 5,387,783 | +2,092,661 | 0.00 | 0.01 | +0.00 | buy |
| PFIZER INC | 5,376,344 | 4,780,401 | -595,943 | 18.60 | 24.14 | +5.55 | sell |
| SR ONE CAPITAL MANAGEMENT, LP | 4,514,929 | 4,514,929 | 0 | 5.34 | 6.39 | +1.04 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 4,504,096 | 4,504,096 | 0 | 0.16 | 0.26 | +0.10 | hold |
| VR Adviser, LLC | 5,676,230 | 4,319,765 | -1,356,465 | 2.29 | 2.04 | -0.25 | sell |
| NEA Management Company, LLC | 4,118,621 | 4,118,621 | 0 | 1.72 | 2.97 | +1.25 | hold |
| STATE STREET CORP | 4,258,397 | 3,702,196 | -556,201 | 0.00 | 0.00 | +0.00 | sell |
| Column Group LLC | 3,540,777 | 3,540,777 | 0 | 34.98 | 44.55 | +9.56 | hold |
| Siren, L.L.C. | 1,007,575 | 2,998,192 | +1,990,617 | 0.25 | 1.05 | +0.81 | buy |
| ORBIMED ADVISORS LLC | 3,641,756 | 2,693,929 | -947,827 | 0.61 | 0.74 | +0.13 | sell |
| FMR LLC | 2,478,922 | 2,434,080 | -44,842 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 2,434,710 | 2,422,741 | -11,969 | 0.01 | 0.02 | +0.01 | sell |
| First Turn Management, LLC | 2,010,307 | 2,017,284 | +6,977 | 1.88 | 2.86 | +0.98 | buy |
| Vivo Capital, LLC | 2,118,384 | 1,848,786 | -269,598 | 1.12 | 1.95 | +0.83 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,750,694 | 1,838,801 | +88,107 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,798,717 | 1,803,945 | +5,228 | 1.68 | 1.77 | +0.08 | buy |
| Paradigm Biocapital Advisors LP | 2,401,217 | 1,701,217 | -700,000 | 0.53 | 0.44 | -0.09 | sell |
| MORGAN STANLEY | 1,194,073 | 1,682,523 | +488,450 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,939,285 | 1,475,712 | -463,573 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,227,230 | 1,471,290 | +244,060 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,212,547 | 1,452,835 | +240,288 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,200,000 | 1,400,000 | +200,000 | 0.50 | 0.94 | +0.44 | buy |
| Woodline Partners LP | 246,534 | 1,247,515 | +1,000,981 | 0.01 | 0.06 | +0.05 | buy |
| ROYCE & ASSOCIATES LP | 1,507,301 | 1,207,223 | -300,078 | 0.13 | 0.15 | +0.03 | sell |
| BRAIDWELL LP | 0 | 1,128,040 | +1,128,040 | 0.00 | 0.48 | +0.48 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,116,604 | 1,100,010 | -16,594 | 1.32 | 1.64 | +0.32 | sell |
| BANK OF AMERICA CORP /DE/ | 507,510 | 1,043,159 | +535,649 | 0.00 | 0.00 | +0.00 | buy |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 2.19 | 3.20 | +1.00 | hold |
| ArrowMark Colorado Holdings LLC | 1,063,769 | 960,517 | -103,252 | 0.19 | 0.32 | +0.13 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 952,371 | 953,451 | +1,080 | 0.12 | 0.20 | +0.08 | buy |
| Logos Global Management LP | 450,000 | 950,000 | +500,000 | 0.25 | 0.62 | +0.37 | buy |
| Qube Research & Technologies Ltd | 1,205,429 | 859,491 | -345,938 | 0.01 | 0.02 | +0.00 | sell |
| NORTHERN TRUST CORP | 885,475 | 710,861 | -174,614 | 0.00 | 0.00 | +0.00 | sell |
| Sofinnova Investments, Inc. | 0 | 679,578 | +679,578 | 0.00 | 0.43 | +0.43 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 621,086 | 605,037 | -16,049 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 0 | 574,085 | +574,085 | 0.00 | 0.04 | +0.04 | buy |
| LORD, ABBETT & CO. LLC | 564,253 | 542,598 | -21,655 | 0.01 | 0.02 | +0.01 | sell |
| Polar Capital Holdings Plc | 502,364 | 539,377 | +37,013 | 0.02 | 0.03 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,004,378 | 537,628 | -466,750 | 1.72 | 1.17 | -0.55 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 950,214 | 523,790 | -426,424 | 0.01 | 0.01 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 350,884 | 522,061 | +171,177 | 0.01 | 0.02 | +0.01 | buy |
| Redmile Group, LLC | 448,110 | 415,710 | -32,400 | 0.27 | 0.35 | +0.08 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 332,760 | 405,280 | +72,520 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 549,000 | 344,315 | -204,685 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 414,786 | 323,584 | -91,202 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 207,037 | 263,059 | +56,022 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 169,830 | 258,602 | +88,772 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 289,962 | 226,804 | -63,158 | 0.19 | 0.21 | +0.02 | sell |
| UBS Group AG | 734,858 | 194,689 | -540,169 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 187,921 | 190,470 | +2,549 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 108,835 | 186,145 | +77,310 | 0.01 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 191,823 | 186,099 | -5,724 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128,649 | 182,139 | +53,490 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 176,500 | +176,500 | 0.00 | 0.29 | +0.29 | buy |
| AQR CAPITAL MANAGEMENT LLC | 174,279 | 170,087 | -4,192 | 0.00 | 0.00 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 170,072 | 160,054 | -10,018 | 0.05 | 0.07 | +0.02 | sell |
| Nuveen, LLC | 144,403 | 153,022 | +8,619 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 515,000 | 150,000 | -365,000 | 1.30 | 0.51 | -0.79 | sell |
| AMERICAN CENTURY COMPANIES INC | 134,930 | 146,804 | +11,874 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 137,489 | +137,489 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 40,510 | 136,350 | +95,840 | 0.01 | 0.03 | +0.02 | buy |
| Rafferty Asset Management, LLC | 177,179 | 115,480 | -61,699 | 0.01 | 0.01 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 255,370 | 115,234 | -140,136 | 1.12 | 1.04 | -0.08 | sell |
| Y-Intercept (Hong Kong) Ltd | 341,423 | 111,992 | -229,431 | 0.06 | 0.03 | -0.04 | sell |
| Invesco Ltd. | 109,742 | 108,954 | -788 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 141,045 | 98,724 | -42,321 | 0.27 | 0.22 | -0.05 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 96,145 | +96,145 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 86,200 | 86,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 77,706 | 79,063 | +1,357 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 63,810 | 63,810 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 218,610 | 61,957 | -156,653 | 0.05 | 0.02 | -0.03 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 59,563 | +59,563 | 0.00 | 0.03 | +0.03 | buy |
| Tidal Investments LLC | 0 | 57,602 | +57,602 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 27,854 | 57,227 | +29,373 | 0.02 | 0.05 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 50,782 | 54,239 | +3,457 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 244,033 | 53,037 | -190,996 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 65,160 | 51,519 | -13,641 | 0.02 | 0.02 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 44,937 | 51,333 | +6,396 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,959 | 48,369 | +14,410 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 46,070 | +46,070 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 16,022 | 44,390 | +28,368 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 110,565 | 43,291 | -67,274 | 0.02 | 0.01 | -0.01 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 43,137 | +43,137 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 42,446 | +42,446 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,057 | 39,188 | -1,869 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 82,532 | 39,108 | -43,424 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 124,345 | 38,295 | -86,050 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 33,970 | 35,689 | +1,719 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 35,267 | 35,267 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 97,432 | 34,012 | -63,420 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 33,688 | +33,688 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 39,612 | 32,328 | -7,284 | 0.16 | 0.20 | +0.04 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 29,815 | +29,815 | 0.00 | 0.02 | +0.02 | buy |
| Graham Capital Management, L.P. | 81,576 | 29,434 | -52,142 | 0.02 | 0.01 | -0.01 | sell |
| Legal & General Group Plc | 33,839 | 29,336 | -4,503 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 28,361 | 29,069 | +708 | 0.06 | 0.10 | +0.04 | buy |