| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,295,122 | 5,387,783 | +2,092,661 | 0.00 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 1,007,575 | 2,998,192 | +1,990,617 | 0.25 | 1.05 | +0.81 | buy |
| BRAIDWELL LP | 0 | 1,128,040 | +1,128,040 | 0.00 | 0.48 | +0.48 | buy |
| Woodline Partners LP | 246,534 | 1,247,515 | +1,000,981 | 0.01 | 0.06 | +0.05 | buy |
| Sofinnova Investments, Inc. | 0 | 679,578 | +679,578 | 0.00 | 0.43 | +0.43 | buy |
| Candriam S.C.A. | 0 | 574,085 | +574,085 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 507,510 | 1,043,159 | +535,649 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 450,000 | 950,000 | +500,000 | 0.25 | 0.62 | +0.37 | buy |
| MORGAN STANLEY | 1,194,073 | 1,682,523 | +488,450 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,227,230 | 1,471,290 | +244,060 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,212,547 | 1,452,835 | +240,288 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,200,000 | 1,400,000 | +200,000 | 0.50 | 0.94 | +0.44 | buy |
| Boxer Capital Management, LLC | 0 | 176,500 | +176,500 | 0.00 | 0.29 | +0.29 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 350,884 | 522,061 | +171,177 | 0.01 | 0.02 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 137,489 | +137,489 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 5,875,053 | 5,984,552 | +109,499 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 96,145 | +96,145 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 40,510 | 136,350 | +95,840 | 0.01 | 0.03 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 169,830 | 258,602 | +88,772 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,750,694 | 1,838,801 | +88,107 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 108,835 | 186,145 | +77,310 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 332,760 | 405,280 | +72,520 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 59,563 | +59,563 | 0.00 | 0.03 | +0.03 | buy |
| Tidal Investments LLC | 0 | 57,602 | +57,602 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 207,037 | 263,059 | +56,022 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128,649 | 182,139 | +53,490 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 46,070 | +46,070 | 0.00 | 0.04 | +0.04 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 43,137 | +43,137 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 42,446 | +42,446 | 0.00 | 0.02 | +0.02 | buy |
| Polar Capital Holdings Plc | 502,364 | 539,377 | +37,013 | 0.02 | 0.03 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 33,688 | +33,688 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 29,815 | +29,815 | 0.00 | 0.02 | +0.02 | buy |
| TEMA ETFS LLC | 27,854 | 57,227 | +29,373 | 0.02 | 0.05 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 16,022 | 44,390 | +28,368 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 23,972 | +23,972 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 14,978 | +14,978 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 14,517 | +14,517 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,959 | 48,369 | +14,410 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 12,390 | +12,390 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 134,930 | 146,804 | +11,874 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 11,747 | +11,747 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 11,373 | +11,373 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 13,490 | 23,899 | +10,409 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 144,403 | 153,022 | +8,619 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 443 | 8,984 | +8,541 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 2,010,307 | 2,017,284 | +6,977 | 1.88 | 2.86 | +0.98 | buy |
| DEUTSCHE BANK AG\ | 44,937 | 51,333 | +6,396 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 16,000 | 21,840 | +5,840 | 0.02 | 0.06 | +0.03 | buy |
| MPM BioImpact LLC | 1,798,717 | 1,803,945 | +5,228 | 1.68 | 1.77 | +0.08 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,643 | 19,332 | +3,689 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 50,782 | 54,239 | +3,457 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 2,679 | +2,679 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 187,921 | 190,470 | +2,549 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 23,356 | 25,526 | +2,170 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,870 | 17,809 | +1,939 | 0.01 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 33,970 | 35,689 | +1,719 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 14,774 | 16,466 | +1,692 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 1,650 | +1,650 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 77,706 | 79,063 | +1,357 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 952,371 | 953,451 | +1,080 | 0.12 | 0.20 | +0.08 | buy |
| SECTORAL ASSET MANAGEMENT INC | 22,480 | 23,500 | +1,020 | 0.15 | 0.28 | +0.13 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,410 | 3,310 | +900 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 496 | 1,348 | +852 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,581 | 5,413 | +832 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 28,361 | 29,069 | +708 | 0.06 | 0.10 | +0.04 | buy |
| Rockefeller Capital Management L.P. | 0 | 573 | +573 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,732 | 5,235 | +503 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 647 | 1,114 | +467 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,934 | 11,222 | +288 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,913 | 2,176 | +263 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 252 | 508 | +256 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 173 | +173 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 147 | +147 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| JPL Wealth Management, LLC | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 12,037 | 12,095 | +58 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 720 | 773 | +53 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 503 | 552 | +49 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 45 | 77 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Root Financial Partners, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 292 | 298 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 5,593 | 5,593 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 63,810 | 63,810 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 4,504,096 | 4,504,096 | 0 | 0.16 | 0.26 | +0.10 | hold |
| JANUS HENDERSON GROUP PLC | 14,400 | 14,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ASSETMARK, INC | 3,000 | 3,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jasper Ridge Partners, L.P. | 20,870 | 20,870 | 0 | 0.00 | 0.01 | +0.00 | hold |
| SIGNATUREFD, LLC | 83 | 83 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 4,118,621 | 4,118,621 | 0 | 1.72 | 2.97 | +1.25 | hold |
| LMR Partners LLP | 35,267 | 35,267 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 86,200 | 86,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 6,728,116 | 6,728,116 | 0 | 2.51 | 3.64 | +1.13 | hold |
| Nextech Invest, Ltd. | 7,162,637 | 7,162,637 | 0 | 5.66 | 6.39 | +0.72 | hold |
| IFP Advisors, Inc | 297 | 297 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 83 | 83 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KLP KAPITALFORVALTNING AS | 9,300 | 9,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 2.19 | 3.20 | +1.00 | hold |
| Column Group LLC | 3,540,777 | 3,540,777 | 0 | 34.98 | 44.55 | +9.56 | hold |