| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 849,681 | 1,269,676 | +419,995 | 0.92 | 0.83 | -0.09 | buy |
| First Turn Management, LLC | 1,097,571 | 1,515,960 | +418,389 | 2.26 | 1.74 | -0.51 | buy |
| Monaco Asset Management SAM | 130,000 | 301,650 | +171,650 | 0.79 | 1.07 | +0.27 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 3,704,096 | 3,804,096 | +100,000 | 0.09 | 0.04 | -0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 92,366 | 114,366 | +22,000 | 0.09 | 0.05 | 0.00 | buy |
| Atom Investors LP | 31,395 | 36,901 | +5,506 | 0.05 | 0.03 | -0.03 | buy |
| Rafferty Asset Management, LLC | 111,146 | 116,208 | +5,062 | 0.01 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,437 | 11,787 | +2,350 | 0.07 | 0.04 | -0.03 | buy |
| China Universal Asset Management Co., Ltd. | 12,922 | 7,922 | -5,000 | 0.02 | 0.01 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 103,992 | 96,000 | -7,992 | 0.93 | 0.57 | -0.36 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,113,007 | 1,075,812 | -37,195 | 4.29 | 1.88 | -2.41 | sell |
| FRED ALGER MANAGEMENT, LLC | 219,943 | 155,912 | -64,031 | 0.01 | 0.01 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 1,510,861 | 1,273,522 | -237,339 | 0.23 | 0.11 | -0.13 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,030,400 | 780,400 | -250,000 | 0.03 | 0.01 | -0.02 | sell |
| Soleus Capital Management, L.P. | 421,000 | 163,000 | -258,000 | 0.51 | 0.10 | -0.41 | sell |