| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,024,600 | 4,920,360 | -104,240 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 4,394,527 | 4,394,527 | 0 | 2.87 | 1.98 | -0.90 | hold |
| Frazier Life Sciences Management, L.P. | 4,142,855 | 4,142,855 | 0 | 2.40 | 1.37 | -1.03 | hold |
| VIKING GLOBAL INVESTORS LP | 4,000,000 | 4,000,000 | 0 | 0.20 | 0.11 | -0.10 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 3,704,096 | 3,804,096 | +100,000 | 0.28 | 0.14 | -0.14 | buy |
| Column Group LLC | 3,540,777 | 3,540,777 | 0 | 30.33 | 35.12 | +4.79 | hold |
| EcoR1 Capital, LLC | 3,418,068 | 3,418,068 | 0 | 1.19 | 0.74 | -0.45 | hold |
| VANGUARD GROUP INC | 2,882,055 | 3,199,726 | +317,671 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,716,081 | 2,256,228 | +540,147 | 0.00 | 0.00 | -0.00 | buy |
| Commodore Capital LP | 2,000,000 | 2,000,000 | 0 | 1.84 | 0.97 | -0.87 | hold |
| First Turn Management, LLC | 1,097,571 | 1,515,960 | +418,389 | 2.26 | 1.74 | -0.51 | buy |
| NEA Management Company, LLC | 1,500,000 | 1,500,000 | 0 | 1.28 | 0.80 | -0.48 | hold |
| ArrowMark Colorado Holdings LLC | 1,510,861 | 1,273,522 | -237,339 | 0.23 | 0.11 | -0.13 | sell |
| Vivo Capital, LLC | 849,681 | 1,269,676 | +419,995 | 0.92 | 0.83 | -0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 911,633 | 1,222,692 | +311,059 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,566,736 | 1,189,227 | -377,509 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,113,007 | 1,075,812 | -37,195 | 4.29 | 1.88 | -2.41 | sell |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 1.74 | 0.88 | -0.87 | hold |
| MILLENNIUM MANAGEMENT LLC | 196,852 | 782,299 | +585,447 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,030,400 | 780,400 | -250,000 | 0.03 | 0.01 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 750,516 | 753,655 | +3,139 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 160,802 | 466,662 | +305,860 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 300,823 | 423,922 | +123,099 | 0.00 | 0.00 | -0.00 | buy |
| Altium Capital Management LLC | 405,000 | 405,000 | 0 | 2.49 | 1.18 | -1.30 | hold |
| NORTHERN TRUST CORP | 353,341 | 359,026 | +5,685 | 0.00 | 0.00 | -0.00 | buy |
| Monaco Asset Management SAM | 130,000 | 301,650 | +171,650 | 0.79 | 1.07 | +0.27 | buy |
| ORBIMED ADVISORS LLC | 287,100 | 287,100 | 0 | 0.07 | 0.04 | -0.03 | hold |
| GOLDMAN SACHS GROUP INC | 169,678 | 278,810 | +109,132 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 201,122 | 276,489 | +75,367 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 109,009 | 262,514 | +153,505 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 115,090 | 186,484 | +71,394 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 421,000 | 163,000 | -258,000 | 0.51 | 0.10 | -0.41 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 104,544 | 162,366 | +57,822 | 0.00 | 0.00 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 219,943 | 155,912 | -64,031 | 0.01 | 0.01 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 143,943 | 143,943 | 0 | 0.02 | 0.01 | -0.01 | hold |
| TD ASSET MANAGEMENT INC | 208,600 | 139,400 | -69,200 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 121,926 | 131,350 | +9,424 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 111,973 | 122,823 | +10,850 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 111,146 | 116,208 | +5,062 | 0.01 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 92,366 | 114,366 | +22,000 | 0.04 | 0.02 | -0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 102,741 | +102,741 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 102,434 | +102,434 | 0.00 | 0.04 | +0.04 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 103,992 | 96,000 | -7,992 | 0.93 | 0.57 | -0.36 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 88,540 | 95,850 | +7,310 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 60,300 | 92,702 | +32,402 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 73,167 | 84,201 | +11,034 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 53,043 | 81,227 | +28,184 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 94,061 | 80,807 | -13,254 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 29,100 | 80,100 | +51,000 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 72,712 | +72,712 | 0.00 | 0.24 | +0.24 | buy |
| M&T BANK CORP | 71,405 | 71,426 | +21 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 0 | 66,300 | +66,300 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 33,154 | 50,787 | +17,633 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 110,900 | 47,000 | -63,900 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 30,160 | 44,050 | +13,890 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 42,320 | +42,320 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 31,395 | 36,901 | +5,506 | 0.05 | 0.03 | -0.03 | buy |
| Corton Capital Inc. | 0 | 36,643 | +36,643 | 0.00 | 0.14 | +0.14 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 36,223 | +36,223 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 20,737 | 36,078 | +15,341 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 0 | 36,000 | +36,000 | 0.00 | 0.06 | +0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,924 | 35,104 | +31,180 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 34,228 | +34,228 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 34,045 | +34,045 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 17,371 | 33,984 | +16,613 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 29,205 | 33,391 | +4,186 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 3,253 | 32,519 | +29,266 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 25,325 | 29,361 | +4,036 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 133,906 | 27,490 | -106,416 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 15,217 | 26,779 | +11,562 | 0.00 | 0.00 | -0.00 | buy |
| Alpine Global Management, LLC | 0 | 22,815 | +22,815 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 494,168 | 22,620 | -471,548 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 17,686 | 21,861 | +4,175 | 0.01 | 0.01 | -0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 21,738 | +21,738 | 0.00 | 0.03 | +0.03 | buy |
| XTX Topco Ltd | 0 | 21,638 | +21,638 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,029 | 21,245 | +8,216 | 0.00 | 0.00 | -0.00 | buy |
| Jasper Ridge Partners, L.P. | 20,870 | 20,870 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 0 | 19,723 | +19,723 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 44,714 | 16,229 | -28,485 | 0.00 | 0.00 | -0.00 | sell |
| Clear Harbor Asset Management, LLC | 13,744 | 13,744 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Baird Financial Group, Inc. | 12,341 | 12,991 | +650 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 14,298 | 12,241 | -2,057 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 9,437 | 11,787 | +2,350 | 0.07 | 0.04 | -0.03 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 11,310 | +11,310 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 10,290 | 10,839 | +549 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 10,760 | +10,760 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 2,938 | 10,378 | +7,440 | 0.01 | 0.01 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 0 | 8,324 | +8,324 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,922 | 7,922 | -5,000 | 0.02 | 0.01 | -0.01 | sell |
| Ameritas Investment Partners, Inc. | 3,223 | 6,032 | +2,809 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,964 | 5,152 | +3,188 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 750 | 5,003 | +4,253 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,316 | 2,130 | +814 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,013 | +2,013 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,105 | +1,105 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 516 | 661 | +145 | 0.00 | 0.00 | -0.00 | buy |
| Fortitude Family Office, LLC | 574 | 574 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 249 | 249 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 274 | 236 | -38 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 30 | 79 | +49 | 0.00 | 0.00 | -0.00 | buy |