| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 3,182,527 | 6,596,885 | +3,414,358 | 1.51 | 5.02 | +3.51 | buy |
| NEA Management Company, LLC | 2,195,545 | 4,118,621 | +1,923,076 | 0.94 | 3.15 | +2.20 | buy |
| Nextech Invest, Ltd. | 5,285,714 | 7,162,637 | +1,876,923 | 6.85 | 13.76 | +6.90 | buy |
| Vivo Capital, LLC | 2,080,450 | 3,126,604 | +1,046,154 | 1.54 | 3.25 | +1.71 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 4,004,096 | 4,504,096 | +500,000 | 0.05 | 0.08 | +0.03 | buy |
| MPM BioImpact LLC | 1,399,514 | 1,729,378 | +329,864 | 1.34 | 3.04 | +1.70 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,007,272 | 1,777,744 | +229,528 | 0.03 | 0.04 | 0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 20,000 | 231,485 | +211,485 | 0.09 | 1.55 | +1.46 | buy |
| ORBIMED ADVISORS LLC | 700,000 | 899,281 | +199,281 | 0.09 | 0.23 | +0.14 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 234,834 | 394,693 | +159,859 | 0.30 | 0.94 | +0.64 | buy |
| Atom Investors LP | 210,706 | 252,653 | +41,947 | 0.14 | 0.23 | +0.08 | buy |
| AXQ CAPITAL, LP | 10,061 | 12,950 | +2,889 | 0.02 | 0.04 | +0.02 | buy |
| ANTIPODES PARTNERS Ltd | 3,822 | 5,194 | +1,372 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 47,642 | 49,000 | +1,358 | 0.02 | 0.03 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,247 | 14,278 | +31 | 0.01 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 156,643 | 149,726 | -6,917 | 0.04 | 0.06 | +0.02 | sell |
| Virtus Investment Advisers, LLC | 19,473 | 9,724 | -9,749 | 0.03 | 0.03 | +0.00 | sell |
| First Turn Management, LLC | 2,027,430 | 2,009,923 | -17,507 | 2.28 | 3.81 | +1.53 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 69,036 | 43,393 | -25,643 | 0.01 | 0.01 | +0.01 | sell |
| Rafferty Asset Management, LLC | 77,424 | 42,644 | -34,780 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 1,346,189 | 1,278,454 | -67,735 | 0.12 | 0.23 | +0.11 | sell |
| Nicholas Investment Partners, LP | 154,379 | 74,242 | -80,137 | 0.09 | 0.07 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 178,722 | 76,286 | -102,436 | 0.01 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 242,000 | 135,271 | -106,729 | 0.38 | 0.38 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,060,240 | 1,800,829 | -259,411 | 2.40 | 3.74 | +1.34 | sell |
| Frazier Life Sciences Management, L.P. | 1,410,193 | 1,065,334 | -344,859 | 0.36 | 0.43 | +0.07 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 819,194 | 344,922 | -474,272 | 5.45 | 4.36 | -1.09 | sell |
| EcoR1 Capital, LLC | 3,418,068 | 1,618,068 | -1,800,000 | 1.13 | 0.97 | -0.16 | sell |