| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nextech Invest, Ltd. | 5,285,714 | 7,162,637 | +1,876,923 | 6.85 | 13.76 | +6.90 | buy |
| VR Adviser, LLC | 3,182,527 | 6,596,885 | +3,414,358 | 1.51 | 5.02 | +3.51 | buy |
| VIKING GLOBAL INVESTORS LP | 6,572,700 | 6,572,700 | 0 | 0.12 | 0.19 | +0.08 | hold |
| PFIZER INC | 5,376,344 | 5,376,344 | 0 | 5.99 | 9.47 | +3.48 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 0 | 4,514,929 | +4,514,929 | 0.00 | 9.93 | +9.93 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 4,004,096 | 4,504,096 | +500,000 | 0.13 | 0.22 | +0.09 | buy |
| NEA Management Company, LLC | 2,195,545 | 4,118,621 | +1,923,076 | 0.94 | 3.15 | +2.20 | buy |
| BlackRock, Inc. | 5,435,087 | 4,077,985 | -1,357,102 | 0.00 | 0.00 | +0.00 | sell |
| Column Group LLC | 3,540,777 | 3,540,777 | 0 | 44.67 | 54.68 | +10.01 | hold |
| Vivo Capital, LLC | 2,080,450 | 3,126,604 | +1,046,154 | 1.54 | 3.25 | +1.71 | buy |
| VANGUARD GROUP INC | 3,215,887 | 3,124,693 | -91,194 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 2,850,641 | +2,850,641 | 0.00 | 0.07 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,332,860 | 2,762,915 | +1,430,055 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,480,420 | 2,470,057 | -10,363 | 0.00 | 0.00 | +0.00 | sell |
| First Turn Management, LLC | 2,027,430 | 2,009,923 | -17,507 | 2.28 | 3.81 | +1.53 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,060,240 | 1,800,829 | -259,411 | 2.40 | 3.74 | +1.34 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 2,007,272 | 1,777,744 | -229,528 | 0.03 | 0.04 | +0.01 | sell |
| MPM BioImpact LLC | 1,399,514 | 1,729,378 | +329,864 | 1.34 | 3.04 | +1.70 | buy |
| STATE STREET CORP | 2,196,549 | 1,632,116 | -564,433 | 0.00 | 0.00 | +0.00 | sell |
| EcoR1 Capital, LLC | 3,418,068 | 1,618,068 | -1,800,000 | 1.13 | 0.97 | -0.16 | sell |
| CITADEL ADVISORS LLC | 511,889 | 1,402,768 | +890,879 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 35,649 | 1,335,448 | +1,299,799 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 1,346,189 | 1,278,454 | -67,735 | 0.12 | 0.23 | +0.11 | sell |
| Integral Health Asset Management, LLC | 0 | 1,250,000 | +1,250,000 | 0.00 | 1.19 | +1.19 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,305,991 | 1,108,460 | -197,531 | 0.00 | 0.00 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 1,410,193 | 1,065,334 | -344,859 | 0.36 | 0.43 | +0.07 | sell |
| FRANKLIN RESOURCES INC | 1,022,790 | 1,042,558 | +19,768 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 1,007,575 | 1,007,575 | 0 | 0.32 | 0.53 | +0.21 | hold |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 2.07 | 3.28 | +1.21 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 951,433 | +951,433 | 0.00 | 0.17 | +0.17 | buy |
| ORBIMED ADVISORS LLC | 700,000 | 899,281 | +199,281 | 0.09 | 0.23 | +0.14 | buy |
| DIMENSIONAL FUND ADVISORS LP | 727,830 | 714,866 | -12,964 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 294,784 | 489,637 | +194,853 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 485,629 | +485,629 | 0.00 | 4.10 | +4.10 | buy |
| NORTHERN TRUST CORP | 546,746 | 400,954 | -145,792 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 0 | 394,785 | +394,785 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 234,834 | 394,693 | +159,859 | 0.32 | 1.05 | +0.72 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 408,505 | 382,389 | -26,116 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 365,400 | +365,400 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 53,983 | 350,535 | +296,552 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 819,194 | 344,922 | -474,272 | 5.45 | 4.36 | -1.09 | sell |
| BANK OF AMERICA CORP /DE/ | 259,801 | 298,442 | +38,641 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 210,706 | 252,653 | +41,947 | 0.14 | 0.23 | +0.08 | buy |
| Woodline Partners LP | 0 | 244,368 | +244,368 | 0.00 | 0.01 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 0 | 234,774 | +234,774 | 0.00 | 0.02 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 20,000 | 231,485 | +211,485 | 0.09 | 1.55 | +1.46 | buy |
| Resolute Capital Asset Partners LLC | 0 | 227,515 | +227,515 | 0.00 | 1.21 | +1.21 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 178,217 | 223,302 | +45,085 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 200,785 | +200,785 | 0.00 | 0.66 | +0.66 | buy |
| TD ASSET MANAGEMENT INC | 152,700 | 177,700 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 49,530 | 171,433 | +121,903 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 156,643 | 149,726 | -6,917 | 0.04 | 0.06 | +0.02 | sell |
| BARCLAYS PLC | 101,790 | 142,681 | +40,891 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 126,681 | 141,000 | +14,319 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 242,000 | 135,271 | -106,729 | 0.38 | 0.38 | -0.00 | sell |
| Bank of New York Mellon Corp | 166,154 | 135,034 | -31,120 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 150,260 | 132,630 | -17,630 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 129,657 | 124,108 | -5,549 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 167,502 | 122,686 | -44,816 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 0 | 106,767 | +106,767 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 102,583 | +102,583 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 99,899 | +99,899 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 79,538 | 99,006 | +19,468 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 112,628 | 91,210 | -21,418 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 7,215 | 86,755 | +79,540 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 76,447 | +76,447 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 178,722 | 76,286 | -102,436 | 0.01 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 154,379 | 74,242 | -80,137 | 0.09 | 0.07 | -0.02 | sell |
| RHUMBLINE ADVISERS | 88,753 | 71,431 | -17,322 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 107,432 | 63,810 | -43,622 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 40,419 | 61,563 | +21,144 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 47,642 | 49,000 | +1,358 | 0.01 | 0.01 | +0.01 | buy |
| Palumbo Wealth Management LLC | 0 | 46,783 | +46,783 | 0.00 | 0.15 | +0.15 | buy |
| JANE STREET GROUP, LLC | 0 | 46,711 | +46,711 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 69,036 | 43,393 | -25,643 | 0.01 | 0.01 | +0.01 | sell |
| Rafferty Asset Management, LLC | 77,424 | 42,644 | -34,780 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 36,158 | 38,864 | +2,706 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 51,976 | 38,577 | -13,399 | 0.00 | 0.00 | +0.00 | sell |
| LMR Partners LLP | 35,300 | 35,267 | -33 | 0.00 | 0.01 | +0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 34,725 | +34,725 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,988 | 33,603 | -5,385 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 35,285 | 33,530 | -1,755 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 104,106 | 32,549 | -71,557 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 40,856 | 27,072 | -13,784 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,201 | 26,658 | -13,543 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,782 | 25,875 | -14,907 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 40,766 | 25,447 | -15,319 | 0.00 | 0.00 | +0.00 | sell |
| IEQ CAPITAL, LLC | 0 | 22,987 | +22,987 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 20,903 | +20,903 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 20,892 | +20,892 | 0.00 | 0.04 | +0.04 | buy |
| Jasper Ridge Partners, L.P. | 20,870 | 20,870 | 0 | 0.00 | 0.01 | +0.00 | hold |
| AlphaQuest LLC | 42,677 | 20,157 | -22,520 | 0.03 | 0.02 | -0.01 | sell |
| Monaco Asset Management SAM | 0 | 20,000 | +20,000 | 0.00 | 0.08 | +0.08 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 19,668 | +19,668 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,486 | 17,792 | -20,694 | 0.00 | 0.00 | -0.00 | sell |
| Clear Harbor Asset Management, LLC | 15,119 | 15,119 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TWO SIGMA SECURITIES, LLC | 0 | 14,332 | +14,332 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 14,247 | 14,278 | +31 | 0.01 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 10,061 | 12,950 | +2,889 | 0.02 | 0.04 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,885 | 12,728 | -4,157 | 0.00 | 0.00 | +0.00 | sell |