| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Candriam S.C.A. | 574,085 | 1,179,768 | +605,683 | 0.04 | 0.06 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 537,628 | 752,983 | +215,355 | 1.08 | 1.06 | -0.02 | buy |
| MPM BioImpact LLC | 1,803,945 | 1,882,162 | +78,217 | 1.77 | 1.24 | -0.52 | buy |
| China Universal Asset Management Co., Ltd. | 17,809 | 22,153 | +4,344 | 0.02 | 0.01 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 953,451 | 954,768 | +1,317 | 0.20 | 0.14 | -0.06 | buy |
| TEMA ETFS LLC | 57,227 | 57,977 | +750 | 0.05 | 0.02 | -0.03 | buy |
| Redmile Group, LLC | 415,710 | 362,010 | -53,700 | 0.35 | 0.26 | -0.09 | sell |
| ArrowMark Colorado Holdings LLC | 960,517 | 582,875 | -377,642 | 0.32 | 0.26 | -0.06 | sell |
| VIKING GLOBAL INVESTORS LP | 5,824,533 | 5,126,762 | -697,771 | 0.21 | 0.16 | -0.05 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 4,504,096 | 3,739,096 | -765,000 | 0.10 | 0.05 | -0.04 | sell |
| PFIZER INC | 4,780,401 | 372,904 | -4,407,497 | 24.14 | 2.09 | -22.06 | sell |