| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 4,394,527 | 4,394,527 | 0 | 1.98 | 2.36 | +0.38 | hold |
| FMR LLC | 4,920,360 | 4,378,819 | -541,541 | 0.00 | 0.00 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 4,142,855 | 4,142,855 | 0 | 1.37 | 1.70 | +0.33 | hold |
| VIKING GLOBAL INVESTORS LP | 4,000,000 | 4,000,000 | 0 | 0.11 | 0.15 | +0.04 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 3,804,096 | 3,904,096 | +100,000 | 0.14 | 0.22 | +0.08 | buy |
| Column Group LLC | 3,540,777 | 3,540,777 | 0 | 35.12 | 52.16 | +17.04 | hold |
| EcoR1 Capital, LLC | 3,418,068 | 3,418,068 | 0 | 0.74 | 1.20 | +0.46 | hold |
| VANGUARD GROUP INC | 3,199,726 | 3,167,311 | -32,415 | 0.00 | 0.00 | +0.00 | sell |
| Commodore Capital LP | 2,000,000 | 2,000,000 | 0 | 0.97 | 1.28 | +0.32 | hold |
| STATE STREET CORP | 2,256,228 | 1,938,169 | -318,059 | 0.00 | 0.00 | +0.00 | sell |
| NEA Management Company, LLC | 1,500,000 | 1,500,000 | 0 | 0.80 | 0.84 | +0.04 | hold |
| First Turn Management, LLC | 1,515,960 | 1,451,037 | -64,923 | 1.74 | 2.35 | +0.61 | sell |
| Avidity Partners Management LP | 0 | 1,447,119 | +1,447,119 | 0.00 | 0.76 | +0.76 | buy |
| ArrowMark Colorado Holdings LLC | 1,273,522 | 1,354,508 | +80,986 | 0.11 | 0.18 | +0.07 | buy |
| Vivo Capital, LLC | 1,269,676 | 1,277,818 | +8,142 | 0.83 | 1.08 | +0.25 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,222,692 | 1,273,513 | +50,821 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,131,066 | +1,131,066 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,189,227 | 1,114,885 | -74,342 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,075,812 | 1,099,490 | +23,678 | 1.88 | 2.54 | +0.66 | buy |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 0.88 | 1.12 | +0.24 | hold |
| FRANKLIN RESOURCES INC | 753,655 | 950,459 | +196,804 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 949,522 | +949,522 | 0.00 | 8.70 | +8.70 | buy |
| DIMENSIONAL FUND ADVISORS LP | 466,662 | 613,951 | +147,289 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 780,400 | 575,000 | -205,400 | 0.01 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 359,026 | 525,914 | +166,888 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 162,366 | 410,229 | +247,863 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 423,922 | 371,727 | -52,195 | 0.00 | 0.00 | +0.00 | sell |
| Altium Capital Management LLC | 405,000 | 355,000 | -50,000 | 1.18 | 1.08 | -0.10 | sell |
| GOLDMAN SACHS GROUP INC | 278,810 | 322,625 | +43,815 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 782,299 | 293,523 | -488,776 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 155,912 | 219,447 | +63,535 | 0.01 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 262,514 | 184,075 | -78,439 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 122,823 | 174,388 | +51,565 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 186,484 | 167,170 | -19,314 | 0.00 | 0.00 | +0.00 | sell |
| Monaco Asset Management SAM | 301,650 | 150,561 | -151,089 | 1.07 | 0.65 | -0.42 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 114,366 | 143,320 | +28,954 | 0.02 | 0.04 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 139,400 | 139,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hennion & Walsh Asset Management, Inc. | 102,434 | 137,962 | +35,528 | 0.04 | 0.07 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 131,350 | 130,640 | -710 | 0.00 | 0.00 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 128,396 | +128,396 | 0.00 | 0.22 | +0.22 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 143,943 | 119,083 | -24,860 | 0.01 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 50,787 | 107,261 | +56,474 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 95,850 | 99,750 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 84,201 | 99,503 | +15,302 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 92,702 | 89,247 | -3,455 | 0.00 | 0.00 | +0.00 | sell |
| M&T BANK CORP | 71,426 | 85,137 | +13,711 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 276,489 | 83,950 | -192,539 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 78,435 | +78,435 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 80,807 | 71,555 | -9,252 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 0 | 69,620 | +69,620 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 116,208 | 64,585 | -51,623 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 44,050 | 61,870 | +17,820 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 66,300 | 59,200 | -7,100 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 80,100 | 58,200 | -21,900 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 102,741 | 47,849 | -54,892 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 27,490 | 46,000 | +18,510 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 34,228 | 42,980 | +8,752 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 29,361 | 38,692 | +9,331 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,899 | 36,366 | +12,467 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 36,078 | 36,078 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JPMORGAN CHASE & CO | 0 | 35,251 | +35,251 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 32,519 | 32,928 | +409 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 33,124 | 32,921 | -203 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,104 | 30,942 | -4,162 | 0.00 | 0.00 | +0.00 | sell |
| EntryPoint Capital, LLC | 72,712 | 28,580 | -44,132 | 0.24 | 0.17 | -0.07 | sell |
| WELLS FARGO & COMPANY/MN | 26,779 | 27,546 | +767 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 27,241 | +27,241 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,045 | 25,535 | -8,510 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 0 | 25,220 | +25,220 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 42,320 | 23,034 | -19,286 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 22,620 | 22,082 | -538 | 0.00 | 0.00 | +0.00 | sell |
| Jasper Ridge Partners, L.P. | 20,870 | 20,870 | 0 | 0.00 | 0.01 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 21,245 | 20,595 | -650 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 19,468 | +19,468 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 36,643 | 17,440 | -19,203 | 0.14 | 0.09 | -0.05 | sell |
| Squarepoint Ops LLC | 33,984 | 16,666 | -17,318 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,229 | 16,229 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 0 | 15,802 | +15,802 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 12,991 | 15,691 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 13,744 | 13,744 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 47,000 | 13,700 | -33,300 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,922 | 13,568 | +5,646 | 0.01 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 21,861 | 13,502 | -8,359 | 0.01 | 0.01 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 12,832 | +12,832 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 11,787 | 11,997 | +210 | 0.04 | 0.06 | +0.02 | buy |
| XTX Topco Ltd | 21,638 | 11,757 | -9,881 | 0.01 | 0.01 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,310 | 11,310 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 0 | 11,272 | +11,272 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 11,109 | +11,109 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 10,760 | 10,997 | +237 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 10,839 | 10,731 | -108 | 0.00 | 0.00 | +0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 21,738 | 10,063 | -11,675 | 0.03 | 0.03 | +0.01 | sell |
| SHELL ASSET MANAGEMENT CO | 8,965 | 8,824 | -141 | 0.00 | 0.00 | +0.00 | sell |
| CANADA LIFE ASSURANCE Co | 8,324 | 8,324 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,032 | 6,032 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,152 | 5,117 | -35 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,013 | 2,551 | +538 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 2,309 | +2,309 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,130 | 2,130 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |