| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nextech Invest, Ltd. | 7,162,637 | 7,162,637 | 0 | 13.76 | 13.08 | -0.68 | hold |
| EcoR1 Capital, LLC | 1,618,068 | 6,728,116 | +5,110,048 | 0.97 | 3.87 | +2.90 | buy |
| VR Adviser, LLC | 6,596,885 | 6,596,885 | 0 | 5.02 | 4.46 | -0.56 | hold |
| VIKING GLOBAL INVESTORS LP | 6,572,700 | 6,572,700 | 0 | 0.19 | 0.20 | +0.01 | hold |
| PFIZER INC | 5,376,344 | 5,376,344 | 0 | 9.47 | 14.75 | +5.28 | hold |
| BlackRock, Inc. | 4,077,985 | 5,276,620 | +1,198,635 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,124,693 | 4,650,138 | +1,525,445 | 0.00 | 0.00 | +0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 4,514,929 | 4,514,929 | 0 | 9.93 | 7.84 | -2.10 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 4,504,096 | 4,504,096 | 0 | 0.22 | 0.24 | +0.02 | hold |
| NEA Management Company, LLC | 4,118,621 | 4,118,621 | 0 | 3.15 | 2.71 | -0.43 | hold |
| ORBIMED ADVISORS LLC | 899,281 | 3,641,756 | +2,742,475 | 0.23 | 1.05 | +0.82 | buy |
| Column Group LLC | 3,540,777 | 3,540,777 | 0 | 54.68 | 52.48 | -2.20 | hold |
| Vivo Capital, LLC | 3,126,604 | 3,126,604 | 0 | 3.25 | 3.02 | -0.23 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,762,915 | 2,871,327 | +108,412 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,850,641 | 2,619,914 | -230,727 | 0.07 | 0.07 | -0.00 | sell |
| FMR LLC | 2,470,057 | 2,528,048 | +57,991 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,632,116 | 2,403,939 | +771,823 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 2,009,923 | 2,159,474 | +149,551 | 3.81 | 3.89 | +0.09 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,800,829 | 1,948,808 | +147,979 | 3.74 | 3.39 | -0.36 | buy |
| MPM BioImpact LLC | 1,729,378 | 1,729,378 | 0 | 3.04 | 3.40 | +0.36 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,108,460 | 1,630,744 | +522,284 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,777,744 | 1,519,314 | -258,430 | 0.04 | 0.04 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 234,774 | 1,458,483 | +1,223,709 | 0.02 | 0.17 | +0.15 | buy |
| JPMORGAN CHASE & CO | 1,335,448 | 1,228,528 | -106,920 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 1,402,768 | 1,198,004 | -204,764 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,042,558 | 1,181,329 | +138,771 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 1,278,454 | 1,097,497 | -180,957 | 0.23 | 0.24 | +0.01 | sell |
| Siren, L.L.C. | 1,007,575 | 1,007,575 | 0 | 0.53 | 0.47 | -0.06 | hold |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 3.28 | 4.99 | +1.70 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 951,433 | 951,507 | +74 | 0.17 | 0.19 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 489,637 | 904,812 | +415,175 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 1,250,000 | 900,000 | -350,000 | 1.19 | 0.79 | -0.40 | sell |
| NORTHERN TRUST CORP | 400,954 | 888,535 | +487,581 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 714,866 | 793,871 | +79,005 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 394,785 | 745,528 | +350,743 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 382,389 | 603,207 | +220,818 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 468,610 | +468,610 | 0.00 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 365,400 | 447,366 | +81,966 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 394,693 | 431,693 | +37,000 | 1.05 | 1.23 | +0.18 | buy |
| UBS Group AG | 99,006 | 339,236 | +240,230 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 231,485 | 328,655 | +97,170 | 1.55 | 2.43 | +0.88 | buy |
| Woodline Partners LP | 244,368 | 246,534 | +2,166 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 86,755 | 238,620 | +151,865 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 74,242 | 220,735 | +146,493 | 0.07 | 0.20 | +0.14 | buy |
| BARCLAYS PLC | 142,681 | 184,091 | +41,410 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 135,034 | 175,714 | +40,680 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 171,433 | 171,925 | +492 | 0.00 | 0.00 | -0.00 | buy |
| Resolute Capital Asset Partners LLC | 227,515 | 167,515 | -60,000 | 1.21 | 1.05 | -0.16 | sell |
| STEMPOINT CAPITAL LP | 200,785 | 166,461 | -34,324 | 0.66 | 0.40 | -0.25 | sell |
| TD ASSET MANAGEMENT INC | 177,700 | 151,700 | -26,000 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 223,302 | 150,594 | -72,708 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 148,778 | +148,778 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 149,726 | 147,048 | -2,678 | 0.06 | 0.06 | +0.00 | sell |
| Atom Investors LP | 252,653 | 142,601 | -110,052 | 0.23 | 0.13 | -0.10 | sell |
| MILLENNIUM MANAGEMENT LLC | 350,535 | 140,433 | -210,102 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 122,686 | 137,692 | +15,006 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 132,630 | 132,220 | -410 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 91,210 | 130,576 | +39,366 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 124,108 | 126,664 | +2,556 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 120,644 | +120,644 | 0.00 | 0.96 | +0.96 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 110,833 | +110,833 | 0.00 | 0.03 | +0.03 | buy |
| DAFNA Capital Management LLC | 135,271 | 104,671 | -30,600 | 0.38 | 0.31 | -0.07 | sell |
| BANK OF AMERICA CORP /DE/ | 298,442 | 103,450 | -194,992 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 99,899 | 96,549 | -3,350 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 61,563 | 91,614 | +30,051 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,875 | 89,753 | +63,878 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 344,922 | 89,346 | -255,576 | 4.36 | 1.06 | -3.31 | sell |
| Rafferty Asset Management, LLC | 42,644 | 85,592 | +42,948 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 71,431 | 82,031 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 66,100 | +66,100 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 63,810 | 63,810 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 46,711 | 62,678 | +15,967 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,603 | 50,963 | +17,360 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 49,389 | +49,389 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 34,725 | 49,095 | +14,370 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,792 | 45,077 | +27,285 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 46,783 | 44,026 | -2,757 | 0.15 | 0.17 | +0.02 | sell |
| DEUTSCHE BANK AG\ | 38,577 | 42,497 | +3,920 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 0 | 39,044 | +39,044 | 0.00 | 0.24 | +0.24 | buy |
| LMR Partners LLP | 35,267 | 35,267 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MetLife Investment Management, LLC | 27,072 | 33,970 | +6,898 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,339 | 33,126 | +28,787 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 33,037 | +33,037 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,800 | 32,689 | +29,889 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 31,928 | +31,928 | 0.00 | 0.03 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,658 | 31,371 | +4,713 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 106,767 | 30,733 | -76,034 | 0.00 | 0.00 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 29,851 | +29,851 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 27,524 | +27,524 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 14,278 | 27,024 | +12,746 | 0.01 | 0.03 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 43,393 | 25,518 | -17,875 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 23,235 | +23,235 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 20,870 | 20,870 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PROFUND ADVISORS LLC | 0 | 18,720 | +18,720 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 18,023 | +18,023 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,095 | 17,694 | +6,599 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 25,447 | 17,383 | -8,064 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 20,903 | 17,082 | -3,821 | 0.03 | 0.02 | -0.01 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 16,887 | +16,887 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 16,437 | +16,437 | 0.00 | 0.00 | +0.00 | buy |