| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,132,194 | 7,002,108 | +3,869,914 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 659,054 | +659,054 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 45,115 | 651,561 | +606,446 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 521,142 | +521,142 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 124,191 | 480,331 | +356,140 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 2,142,856 | 2,428,385 | +285,529 | 1.36 | 1.53 | +0.17 | buy |
| Altium Capital Management LLC | 418,706 | 676,000 | +257,294 | 1.47 | 4.29 | +2.82 | buy |
| Prosight Management, LP | 0 | 200,000 | +200,000 | 0.00 | 0.74 | +0.74 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 126,800 | +126,800 | 0.00 | 0.22 | +0.22 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 3,479,289 | 3,604,096 | +124,807 | 0.13 | 0.22 | +0.08 | buy |
| Caption Management, LLC | 0 | 95,260 | +95,260 | 0.00 | 0.10 | +0.10 | buy |
| ArrowMark Colorado Holdings LLC | 1,649,956 | 1,733,819 | +83,863 | 0.12 | 0.18 | +0.05 | buy |
| TD ASSET MANAGEMENT INC | 0 | 80,800 | +80,800 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 719,014 | 793,074 | +74,060 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 31,114 | 105,010 | +73,896 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 72,797 | +72,797 | 0.00 | 0.16 | +0.16 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 72,397 | +72,397 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 777,944 | 849,681 | +71,737 | 0.52 | 0.64 | +0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 820,447 | 874,891 | +54,444 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 54,389 | +54,389 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,123,345 | 1,170,000 | +46,655 | 2.53 | 3.32 | +0.79 | buy |
| BARCLAYS PLC | 7,715 | 54,199 | +46,484 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 37,619 | +37,619 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,383 | 47,831 | +31,448 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 341,537 | 369,222 | +27,685 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 26,056 | +26,056 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 17,272 | 40,973 | +23,701 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 32,436 | 49,550 | +17,114 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 15,320 | +15,320 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 70,964 | 83,926 | +12,962 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 0 | 12,341 | +12,341 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 26,770 | 38,175 | +11,405 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 342,900 | 353,197 | +10,297 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 10,085 | +10,085 | 0.00 | 0.06 | +0.06 | buy |
| LPL Financial LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 26,809 | 35,274 | +8,465 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 7,900 | +7,900 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 25 | 6,563 | +6,538 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 34,241 | 40,547 | +6,306 | 0.05 | 0.07 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 6,305 | +6,305 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 26,500 | 31,700 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 114,650 | 118,679 | +4,029 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,199 | 14,146 | +2,947 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 48,156 | 50,788 | +2,632 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,309 | 13,431 | +2,122 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,738 | 9,255 | +1,517 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 20,681 | 22,043 | +1,362 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 124,850 | 126,030 | +1,180 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 105,882 | 106,601 | +719 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,931 | 16,457 | +526 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 274 | +274 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 163 | +163 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 750,411 | 750,516 | +105 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,223 | 3,223 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jasper Ridge Partners, L.P. | 20,870 | 20,870 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 20,737 | 20,737 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 3,418,068 | 3,418,068 | 0 | 0.70 | 0.82 | +0.11 | hold |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 1.31 | 1.02 | -0.28 | hold |
| Column Group LLC | 3,568,181 | 3,568,181 | 0 | 14.33 | 21.69 | +7.35 | hold |
| Frazier Life Sciences Management, L.P. | 2,142,855 | 2,142,855 | 0 | 0.86 | 1.05 | +0.19 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,149 | 2,149 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 3,253 | 3,253 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NBC SECURITIES, INC. | 118 | 118 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 1,332 | 1,332 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,310 | 11,310 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 143,943 | 143,943 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Crewe Advisors LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 24,692 | 24,676 | -16 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 28 | 0 | -28 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 19,480 | 19,401 | -79 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 3,797 | 3,405 | -392 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 624 | 0 | -624 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 58,581 | 57,904 | -677 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 25,743 | 24,776 | -967 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,612 | 6,425 | -2,187 | 0.00 | 0.00 | +0.00 | sell |
| Dorsey Wright & Associates | 2,513 | 0 | -2,513 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 3,414 | 0 | -3,414 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,701 | 9,570 | -6,131 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 34,018 | 24,515 | -9,503 | 0.02 | 0.02 | +0.00 | sell |
| XTX Topco Ltd | 11,320 | 0 | -11,320 | 0.01 | 0.00 | -0.01 | sell |
| SHERBROOKE PARK ADVISERS LLC | 11,911 | 0 | -11,911 | 0.02 | 0.00 | -0.02 | sell |
| ALGERT GLOBAL LLC | 13,430 | 0 | -13,430 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 15,723 | 0 | -15,723 | 0.01 | 0.00 | -0.01 | sell |
| Virtu Financial LLC | 19,461 | 0 | -19,461 | 0.01 | 0.00 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 22,691 | 0 | -22,691 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 24,400 | 0 | -24,400 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,700 | 22,500 | -26,200 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 133,106 | 105,690 | -27,416 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 32,149 | 0 | -32,149 | 0.01 | 0.00 | -0.01 | sell |
| Pale Fire Capital SE | 33,055 | 0 | -33,055 | 0.02 | 0.00 | -0.02 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 351,502 | 262,956 | -88,546 | 0.04 | 0.08 | +0.04 | sell |
| Monaco Asset Management SAM | 384,793 | 280,000 | -104,793 | 1.17 | 0.99 | -0.18 | sell |
| CITADEL ADVISORS LLC | 145,007 | 0 | -145,007 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 379,800 | 188,500 | -191,300 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 204,500 | 0 | -204,500 | 0.22 | 0.00 | -0.22 | sell |
| D. E. Shaw & Co., Inc. | 307,479 | 98,433 | -209,046 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,588,869 | 2,252,519 | -336,350 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 893,668 | 522,968 | -370,700 | 0.12 | 0.10 | -0.02 | sell |
| Prosight Management, LP | 2,579,802 | 1,578,263 | -1,001,539 | 4.95 | 5.83 | +0.88 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,163,760 | 0 | -1,163,760 | 0.01 | 0.00 | -0.01 | sell |