| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nextech Invest, Ltd. | 7,162,637 | 7,162,637 | 0 | 13.08 | 5.66 | -7.42 | hold |
| EcoR1 Capital, LLC | 6,728,116 | 6,728,116 | 0 | 3.87 | 2.51 | -1.36 | hold |
| VIKING GLOBAL INVESTORS LP | 6,572,700 | 6,572,691 | -9 | 0.20 | 0.14 | -0.06 | sell |
| BlackRock, Inc. | 5,276,620 | 5,875,053 | +598,433 | 0.00 | 0.00 | -0.00 | buy |
| VR Adviser, LLC | 6,596,885 | 5,676,230 | -920,655 | 4.46 | 2.29 | -2.16 | sell |
| PFIZER INC | 5,376,344 | 5,376,344 | 0 | 14.75 | 18.60 | +3.85 | hold |
| VANGUARD GROUP INC | 4,650,138 | 4,541,974 | -108,164 | 0.00 | 0.00 | -0.00 | sell |
| SR ONE CAPITAL MANAGEMENT, LP | 4,514,929 | 4,514,929 | 0 | 7.84 | 5.34 | -2.49 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 4,504,096 | 4,504,096 | 0 | 0.24 | 0.16 | -0.08 | hold |
| STATE STREET CORP | 2,403,939 | 4,258,397 | +1,854,458 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 4,118,621 | 4,118,621 | 0 | 2.71 | 1.72 | -0.99 | hold |
| ORBIMED ADVISORS LLC | 3,641,756 | 3,641,756 | 0 | 1.05 | 0.61 | -0.44 | hold |
| Column Group LLC | 3,540,777 | 3,540,777 | 0 | 52.48 | 34.98 | -17.50 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,871,327 | 3,295,122 | +423,795 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 2,619,914 | 2,923,077 | +303,163 | 0.07 | 0.04 | -0.03 | buy |
| FMR LLC | 2,528,048 | 2,478,922 | -49,126 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,198,004 | 2,434,710 | +1,236,706 | 0.01 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 2,401,217 | +2,401,217 | 0.00 | 0.53 | +0.53 | buy |
| Vivo Capital, LLC | 3,126,604 | 2,118,384 | -1,008,220 | 3.02 | 1.12 | -1.90 | sell |
| First Turn Management, LLC | 2,159,474 | 2,010,307 | -149,167 | 3.89 | 1.88 | -2.01 | sell |
| GOLDMAN SACHS GROUP INC | 904,812 | 1,939,285 | +1,034,473 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,729,378 | 1,798,717 | +69,339 | 3.40 | 1.68 | -1.71 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,630,744 | 1,750,694 | +119,950 | 0.00 | 0.00 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 1,458,483 | 1,507,301 | +48,818 | 0.17 | 0.13 | -0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 793,871 | 1,227,230 | +433,359 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,181,329 | 1,212,547 | +31,218 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 1,205,429 | +1,205,429 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 900,000 | 1,200,000 | +300,000 | 0.79 | 0.50 | -0.29 | buy |
| MORGAN STANLEY | 745,528 | 1,194,073 | +448,545 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,948,808 | 1,116,604 | -832,204 | 3.39 | 1.32 | -2.06 | sell |
| ArrowMark Colorado Holdings LLC | 1,097,497 | 1,063,769 | -33,728 | 0.24 | 0.19 | -0.05 | sell |
| Siren, L.L.C. | 1,007,575 | 1,007,575 | 0 | 0.47 | 0.25 | -0.23 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 431,693 | 1,004,378 | +572,685 | 1.23 | 1.72 | +0.49 | buy |
| Euclidean Capital LLC | 989,410 | 989,410 | 0 | 4.99 | 2.19 | -2.80 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 951,507 | 952,371 | +864 | 0.19 | 0.12 | -0.07 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,519,314 | 950,214 | -569,100 | 0.04 | 0.01 | -0.02 | sell |
| NORTHERN TRUST CORP | 888,535 | 885,475 | -3,060 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 339,236 | 734,858 | +395,622 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 184,091 | 718,535 | +534,444 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 603,207 | 621,086 | +17,879 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,500 | 572,724 | +558,224 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 564,253 | +564,253 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 447,366 | 549,000 | +101,634 | 0.01 | 0.01 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 515,000 | +515,000 | 0.00 | 1.30 | +1.30 | buy |
| BANK OF AMERICA CORP /DE/ | 103,450 | 507,510 | +404,060 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 468,610 | 502,364 | +33,754 | 0.03 | 0.02 | -0.01 | buy |
| Logos Global Management LP | 0 | 450,000 | +450,000 | 0.00 | 0.25 | +0.25 | buy |
| Redmile Group, LLC | 0 | 448,110 | +448,110 | 0.00 | 0.27 | +0.27 | buy |
| JPMORGAN CHASE & CO | 1,228,528 | 414,786 | -813,742 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 16,437 | 350,884 | +334,447 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 341,423 | +341,423 | 0.00 | 0.06 | +0.06 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 132,220 | 332,760 | +200,540 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 142,601 | 289,962 | +147,361 | 0.13 | 0.19 | +0.06 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 89,346 | 255,370 | +166,024 | 1.06 | 1.12 | +0.06 | buy |
| Woodline Partners LP | 246,534 | 246,534 | 0 | 0.01 | 0.01 | -0.01 | hold |
| JANE STREET GROUP, LLC | 62,678 | 244,033 | +181,355 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 30,733 | 229,383 | +198,650 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 110,833 | 218,610 | +107,777 | 0.03 | 0.05 | +0.01 | buy |
| Russell Investments Group, Ltd. | 4,974 | 207,037 | +202,063 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 150,594 | 191,823 | +41,229 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 175,714 | 187,921 | +12,207 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 85,592 | 177,179 | +91,587 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 171,925 | 174,279 | +2,354 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 147,048 | 170,072 | +23,024 | 0.06 | 0.05 | -0.02 | buy |
| TD ASSET MANAGEMENT INC | 151,700 | 169,830 | +18,130 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 10,634 | 154,149 | +143,515 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 137,692 | 144,403 | +6,711 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 104,671 | 141,045 | +36,374 | 0.31 | 0.27 | -0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 130,576 | 134,930 | +4,354 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 126,664 | 128,649 | +1,985 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 89,753 | 124,345 | +34,592 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 110,565 | +110,565 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 91,614 | 109,742 | +18,128 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 108,835 | +108,835 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 140,433 | 97,432 | -43,001 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 49,095 | 89,532 | +40,437 | 0.01 | 0.01 | +0.01 | buy |
| Swiss National Bank | 66,100 | 86,200 | +20,100 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 50,963 | 82,532 | +31,569 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 81,576 | +81,576 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 82,031 | 77,706 | -4,325 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 31,928 | 70,634 | +38,706 | 0.03 | 0.05 | +0.02 | buy |
| PROFUND ADVISORS LLC | 18,720 | 65,160 | +46,440 | 0.01 | 0.02 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 63,810 | 63,810 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 23,235 | 50,782 | +27,547 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 42,497 | 44,937 | +2,440 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 15,500 | 44,387 | +28,887 | 0.01 | 0.02 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,371 | 41,057 | +9,686 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 18,023 | 41,016 | +22,993 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 40,510 | +40,510 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 238,620 | 40,115 | -198,505 | 0.00 | 0.00 | -0.00 | sell |
| Optimize Financial Inc | 39,044 | 39,612 | +568 | 0.24 | 0.16 | -0.08 | buy |
| LMR Partners LLP | 35,267 | 35,267 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 33,970 | 33,970 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,689 | 33,959 | +1,270 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 33,126 | 33,839 | +713 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 11,767 | 28,361 | +16,594 | 0.04 | 0.06 | +0.02 | buy |
| NEOS Investment Management LLC | 0 | 28,269 | +28,269 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 27,854 | +27,854 | 0.00 | 0.02 | +0.02 | buy |
| Palumbo Wealth Management LLC | 44,026 | 27,322 | -16,704 | 0.17 | 0.06 | -0.11 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 17,383 | 26,606 | +9,223 | 0.00 | 0.00 | +0.00 | buy |