| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SPHERA FUNDS MANAGEMENT LTD. | 431,693 | 1,004,378 | +572,685 | 1.09 | 1.59 | +0.50 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,871,327 | 3,295,122 | +423,795 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 900,000 | 1,200,000 | +300,000 | 0.79 | 0.50 | -0.29 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 89,346 | 255,370 | +166,024 | 1.06 | 1.12 | +0.06 | buy |
| Atom Investors LP | 142,601 | 289,962 | +147,361 | 0.13 | 0.19 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 447,366 | 549,000 | +101,634 | 0.01 | 0.01 | -0.00 | buy |
| Rafferty Asset Management, LLC | 85,592 | 177,179 | +91,587 | 0.00 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 1,729,378 | 1,798,717 | +69,339 | 3.40 | 1.68 | -1.71 | buy |
| ROYCE & ASSOCIATES LP | 1,458,483 | 1,507,301 | +48,818 | 0.17 | 0.13 | -0.05 | buy |
| PROFUND ADVISORS LLC | 18,720 | 65,160 | +46,440 | 0.01 | 0.02 | 0.00 | buy |
| DAFNA Capital Management LLC | 104,671 | 141,045 | +36,374 | 0.31 | 0.27 | -0.04 | buy |
| Polar Capital Holdings Plc | 468,610 | 502,364 | +33,754 | 0.03 | 0.02 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 147,048 | 170,072 | +23,024 | 0.06 | 0.05 | -0.02 | buy |
| Virtus Investment Advisers, LLC | 11,767 | 28,361 | +16,594 | 0.04 | 0.06 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 951,507 | 952,371 | +864 | 0.19 | 0.12 | -0.07 | buy |
| Optimize Financial Inc | 39,044 | 39,612 | +568 | 0.24 | 0.16 | -0.08 | buy |
| VIKING GLOBAL INVESTORS LP | 6,572,700 | 6,572,691 | -9 | 0.20 | 0.14 | -0.06 | sell |
| GF FUND MANAGEMENT CO. LTD. | 2,090 | 1,913 | -177 | 0.00 | 0.00 | -0.00 | sell |
| ANTIPODES PARTNERS Ltd | 2,901 | 2,399 | -502 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 27,024 | 15,870 | -11,154 | 0.03 | 0.01 | -0.02 | sell |
| Palumbo Wealth Management LLC | 44,026 | 27,322 | -16,704 | 0.17 | 0.06 | -0.11 | sell |
| ArrowMark Colorado Holdings LLC | 1,097,497 | 1,063,769 | -33,728 | 0.24 | 0.19 | -0.05 | sell |
| First Turn Management, LLC | 2,159,474 | 2,010,307 | -149,167 | 3.89 | 1.88 | -2.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 328,655 | 22,480 | -306,175 | 2.43 | 0.15 | -2.29 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,948,808 | 1,116,604 | -832,204 | 3.39 | 1.32 | -2.06 | sell |
| VR Adviser, LLC | 6,596,885 | 5,676,230 | -920,655 | 4.46 | 2.29 | -2.16 | sell |
| Vivo Capital, LLC | 3,126,604 | 2,118,384 | -1,008,220 | 3.02 | 1.12 | -1.90 | sell |