| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 238,878 | 9,045,481 | +8,806,603 | 0.00 | 0.01 | +0.01 | buy |
| Fairmount Funds Management LLC | 0 | 8,713,000 | +8,713,000 | 0.00 | 16.30 | +16.30 | buy |
| Avoro Capital Advisors LLC | 0 | 3,783,000 | +3,783,000 | 0.00 | 0.97 | +0.97 | buy |
| VR Adviser, LLC | 0 | 3,603,595 | +3,603,595 | 0.00 | 3.48 | +3.48 | buy |
| FCPM III SERVICES B.V. | 0 | 2,441,000 | +2,441,000 | 0.00 | 8.75 | +8.75 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,399,310 | +2,399,310 | 0.00 | 0.66 | +0.66 | buy |
| JANUS HENDERSON GROUP PLC | 1,739 | 2,362,696 | +2,360,957 | 0.02 | 0.03 | +0.01 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 2,311,082 | +2,311,082 | 0.00 | 0.17 | +0.17 | buy |
| Bellevue Group AG | 0 | 2,298,000 | +2,298,000 | 0.00 | 1.42 | +1.42 | buy |
| Commodore Capital LP | 0 | 1,939,000 | +1,939,000 | 0.00 | 2.91 | +2.91 | buy |
| Cormorant Asset Management, LP | 0 | 1,525,000 | +1,525,000 | 0.00 | 1.99 | +1.99 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,448,000 | +1,448,000 | 0.00 | 0.07 | +0.07 | buy |
| AH Capital Management, L.L.C. | 0 | 1,236,157 | +1,236,157 | 0.00 | 2.48 | +2.48 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,223,000 | +1,223,000 | 0.00 | 0.63 | +0.63 | buy |
| Point72 Asset Management, L.P. | 109,000 | 1,193,708 | +1,084,708 | 0.00 | 0.05 | +0.05 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 1,058,000 | +1,058,000 | 0.00 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 0 | 900,000 | +900,000 | 0.00 | 0.65 | +0.65 | buy |
| BRAIDWELL LP | 0 | 894,846 | +894,846 | 0.00 | 0.77 | +0.77 | buy |
| Vestal Point Capital, LP | 0 | 600,000 | +600,000 | 0.00 | 0.43 | +0.43 | buy |
| Blackstone Inc. | 0 | 503,522 | +503,522 | 0.00 | 0.05 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 471,646 | +471,646 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 450,000 | +450,000 | 0.00 | 0.68 | +0.68 | buy |
| Qube Research & Technologies Ltd | 0 | 282,436 | +282,436 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 279,000 | +279,000 | 0.00 | 0.43 | +0.43 | buy |
| Nantahala Capital Management, LLC | 0 | 278,000 | +278,000 | 0.00 | 0.45 | +0.45 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 11,573 | 241,126 | +229,553 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 7,520 | 222,437 | +214,917 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 183,922 | +183,922 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 169,818 | +169,818 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 160,415 | +160,415 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 117,675 | +117,675 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 88,336 | +88,336 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 76,338 | +76,338 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 72,113 | +72,113 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 55,232 | +55,232 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 285,710 | 335,710 | +50,000 | 0.85 | 1.24 | +0.39 | buy |
| NORTHERN TRUST CORP | 0 | 38,882 | +38,882 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 24,456 | +24,456 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 0 | 23,458 | +23,458 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 22,034 | +22,034 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 74,917 | 96,777 | +21,860 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 17,293 | +17,293 | 0.00 | 0.08 | +0.08 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 95,798 | 110,441 | +14,643 | 0.06 | 0.07 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 11,420 | +11,420 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 10,824 | +10,824 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,127 | 11,095 | +9,968 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 9,728 | +9,728 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 9,300 | +9,300 | 0.00 | 0.58 | +0.58 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 7,921 | +7,921 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 6,194 | +6,194 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 5,338 | +5,338 | 0.00 | 0.05 | +0.05 | buy |
| Tower Research Capital LLC (TRC) | 176 | 1,418 | +1,242 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 353 | +353 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sigma Planning Corp | 14,500 | 0 | -14,500 | 0.01 | 0.00 | -0.01 | sell |
| Jain Global LLC | 120,566 | 0 | -120,566 | 0.03 | 0.00 | -0.03 | sell |