| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 222,437 | 3,162,068 | +2,939,631 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 2,058,933 | +2,058,933 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 183,922 | 1,545,500 | +1,361,578 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 894,846 | 1,620,377 | +725,531 | 0.77 | 1.56 | +0.79 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 241,126 | 965,364 | +724,238 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 160,415 | 840,292 | +679,877 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 503,522 | 1,002,971 | +499,449 | 0.05 | 0.09 | +0.03 | buy |
| NORTHERN TRUST CORP | 38,882 | 359,705 | +320,823 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 88,336 | 339,379 | +251,043 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 216,194 | +216,194 | 0.00 | 0.97 | +0.97 | buy |
| AMERIPRISE FINANCIAL INC | 117,675 | 324,929 | +207,254 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 9,045,481 | 9,232,979 | +187,498 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 166,347 | +166,347 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 151,016 | +151,016 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 149,592 | +149,592 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 142,137 | +142,137 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,500 | 142,137 | +129,637 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 98,284 | +98,284 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 72,600 | +72,600 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 65,833 | +65,833 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 55,710 | +55,710 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 52,774 | +52,774 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 48,426 | +48,426 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 47,458 | +47,458 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 40,544 | +40,544 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 11,095 | 43,419 | +32,324 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 31,774 | +31,774 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 31,551 | +31,551 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 31,499 | +31,499 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 353 | 26,788 | +26,435 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 96,777 | 119,027 | +22,250 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 21,838 | +21,838 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 19,874 | +19,874 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 18,800 | +18,800 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 16,710 | +16,710 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 15,746 | +15,746 | 0.00 | 0.10 | +0.10 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 15,745 | +15,745 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 14,066 | +14,066 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 12,140 | +12,140 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 12,009 | +12,009 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 9,728 | 21,584 | +11,856 | 0.00 | 0.01 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 11,699 | +11,699 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 10,765 | +10,765 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 10,323 | +10,323 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 9,984 | +9,984 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 9,921 | +9,921 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 9,700 | +9,700 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 9,505 | +9,505 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 9,118 | +9,118 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 8,905 | +8,905 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 8,755 | +8,755 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 7,971 | +7,971 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 7,799 | +7,799 | 0.00 | 0.01 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 0 | 4,845 | +4,845 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 4,262 | +4,262 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 3,826 | +3,826 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 5,338 | 8,084 | +2,746 | 0.05 | 0.07 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,194 | 8,142 | +1,948 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,418 | 3,143 | +1,725 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 279,000 | 280,000 | +1,000 | 0.43 | 0.34 | -0.09 | buy |
| Sterling Capital Management LLC | 0 | 464 | +464 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 2,399,310 | 2,399,702 | +392 | 0.66 | 0.54 | -0.12 | buy |
| Pacer Advisors, Inc. | 0 | 332 | +332 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 2,311,082 | 2,311,082 | 0 | 0.17 | 0.17 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 1,223,000 | 1,223,000 | 0 | 0.63 | 0.49 | -0.13 | hold |
| Nantahala Capital Management, LLC | 278,000 | 278,000 | 0 | 0.45 | 0.44 | -0.01 | hold |
| AH Capital Management, L.L.C. | 1,236,157 | 1,236,157 | 0 | 2.48 | 0.23 | -2.25 | hold |
| VR Adviser, LLC | 3,603,595 | 3,603,595 | 0 | 3.48 | 2.84 | -0.64 | hold |
| Avoro Capital Advisors LLC | 3,783,000 | 3,783,000 | 0 | 0.97 | 0.88 | -0.08 | hold |
| Ikarian Capital, LLC | 335,710 | 335,710 | 0 | 1.24 | 1.43 | +0.19 | hold |
| Fairmount Funds Management LLC | 8,713,000 | 8,713,000 | 0 | 16.30 | 14.98 | -1.32 | hold |
| Commodore Capital LP | 1,939,000 | 1,939,000 | 0 | 2.91 | 3.00 | +0.10 | hold |
| SBI Securities Co., Ltd. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 900,000 | 900,000 | 0 | 0.65 | 0.48 | -0.17 | hold |
| FCPM III SERVICES B.V. | 2,441,000 | 2,441,000 | 0 | 8.75 | 8.46 | -0.29 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,058,000 | 1,058,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 7,921 | 0 | -7,921 | 0.00 | 0.00 | -0.00 | sell |
| Cannon Global Investment Management, LLC | 9,300 | 0 | -9,300 | 0.58 | 0.00 | -0.58 | sell |
| Schonfeld Strategic Advisors LLC | 10,824 | 0 | -10,824 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 11,420 | 0 | -11,420 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 22,034 | 10,525 | -11,509 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 23,458 | 11,668 | -11,790 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 17,293 | 0 | -17,293 | 0.08 | 0.00 | -0.08 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 24,456 | 0 | -24,456 | 0.04 | 0.00 | -0.04 | sell |
| Affinity Asset Advisors, LLC | 450,000 | 425,000 | -25,000 | 0.68 | 0.54 | -0.14 | sell |
| Vestal Point Capital, LP | 600,000 | 575,000 | -25,000 | 0.43 | 0.35 | -0.08 | sell |
| HRT FINANCIAL LP | 72,113 | 18,638 | -53,475 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 55,232 | 0 | -55,232 | 0.01 | 0.00 | -0.01 | sell |
| Hudson Bay Capital Management LP | 76,338 | 0 | -76,338 | 0.01 | 0.00 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 110,441 | 0 | -110,441 | 0.07 | 0.00 | -0.07 | sell |
| MARSHALL WACE, LLP | 169,818 | 0 | -169,818 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,448,000 | 1,229,127 | -218,873 | 0.07 | 0.06 | -0.02 | sell |
| Qube Research & Technologies Ltd | 282,436 | 0 | -282,436 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 471,646 | 0 | -471,646 | 0.01 | 0.00 | -0.01 | sell |
| Cormorant Asset Management, LP | 1,525,000 | 1,000,000 | -525,000 | 1.99 | 1.33 | -0.66 | sell |
| Bellevue Group AG | 2,298,000 | 1,618,846 | -679,154 | 1.42 | 0.89 | -0.53 | sell |