| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,797,994 | 16,147,032 | +3,349,038 | 0.06 | 0.06 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,808,216 | 10,949,120 | +140,904 | 0.09 | 0.08 | -0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,264,707 | 6,861,097 | +596,390 | 5.89 | 4.90 | -0.99 | buy |
| HHLR ADVISORS, LTD. | 5,984,550 | 5,984,550 | 0 | 7.26 | 7.29 | +0.03 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 2,306,391 | 2,614,423 | +308,032 | 0.03 | 0.03 | +0.00 | buy |
| Capital World Investors | 2,385,960 | 2,385,960 | 0 | 0.03 | 0.02 | -0.00 | hold |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,776,247 | 2,239,774 | +463,527 | 0.62 | 0.66 | +0.04 | buy |
| Capital International Investors | 1,824,687 | 2,181,074 | +356,387 | 0.02 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,865,157 | 2,014,012 | +148,855 | 0.07 | 0.06 | -0.01 | buy |
| Paradigm Biocapital Advisors LP | 1,894,644 | 1,982,006 | +87,362 | 5.34 | 3.91 | -1.43 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,984,826 | 1,890,796 | -94,030 | 0.04 | 0.03 | -0.01 | sell |
| FEDERATED HERMES, INC. | 1,725,972 | 1,537,060 | -188,912 | 0.26 | 0.20 | -0.06 | sell |
| BRAIDWELL LP | 562,600 | 1,243,795 | +681,195 | 1.24 | 2.25 | +1.01 | buy |
| TimesSquare Capital Management, LLC | 1,065,889 | 1,158,500 | +92,611 | 0.94 | 0.94 | +0.00 | buy |
| CITADEL ADVISORS LLC | 165,931 | 1,144,476 | +978,545 | 0.01 | 0.06 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,185,957 | 1,113,158 | -72,799 | 0.03 | 0.02 | -0.01 | sell |
| STATE STREET CORP | 1,036,745 | 1,048,002 | +11,257 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 1,064,542 | 1,046,739 | -17,803 | 0.71 | 0.66 | -0.05 | sell |
| JOHNSON & JOHNSON | 814,586 | 814,586 | 0 | 1.12 | 1.04 | -0.08 | hold |
| Holocene Advisors, LP | 1,760,697 | 761,626 | -999,071 | 0.42 | 0.16 | -0.26 | sell |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 809,574 | 751,935 | -57,639 | 6.84 | 8.31 | +1.46 | sell |
| PFM Health Sciences, LP | 679,076 | 734,293 | +55,217 | 2.45 | 2.05 | -0.40 | buy |
| Avidity Partners Management LP | 685,000 | 668,300 | -16,700 | 1.58 | 1.33 | -0.24 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 608,995 | 552,413 | -56,582 | 0.02 | 0.03 | +0.01 | sell |
| Rock Springs Capital Management LP | 492,444 | 499,486 | +7,042 | 0.73 | 0.71 | -0.02 | buy |
| Artisan Partners Limited Partnership | 517,837 | 492,099 | -25,738 | 0.05 | 0.04 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 440,875 | 462,607 | +21,732 | 0.00 | 0.00 | -0.00 | buy |
| Capital International, Inc./CA/ | 432,216 | 453,664 | +21,448 | 0.41 | 0.34 | -0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 347,589 | 409,553 | +61,964 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 489,126 | 397,199 | -91,927 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 582,150 | 371,091 | -211,059 | 0.03 | 0.02 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 384,896 | 366,388 | -18,508 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 890,487 | 342,033 | -548,454 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 300,406 | 330,323 | +29,917 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 522,667 | 310,408 | -212,259 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 306,666 | 307,335 | +669 | 0.01 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 201,754 | 293,270 | +91,516 | 0.19 | 0.25 | +0.07 | buy |
| Tri Locum Partners LP | 102,215 | 283,773 | +181,558 | 3.02 | 5.52 | +2.50 | buy |
| BAMCO INC /NY/ | 179,568 | 276,827 | +97,259 | 0.03 | 0.04 | +0.01 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 566,023 | 235,493 | -330,530 | 1.85 | 0.63 | -1.22 | sell |
| First Turn Management, LLC | 476,079 | 228,251 | -247,828 | 4.11 | 1.92 | -2.20 | sell |
| Candriam S.C.A. | 241,032 | 221,032 | -20,000 | 0.10 | 0.08 | -0.02 | sell |
| HSBC HOLDINGS PLC | 196,715 | 211,650 | +14,935 | 0.01 | 0.01 | -0.00 | buy |
| Bridgewater Associates, LP | 330,091 | 208,900 | -121,191 | 0.11 | 0.06 | -0.05 | sell |
| BARCLAYS PLC | 187,385 | 206,507 | +19,122 | 0.01 | 0.01 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 238,216 | 186,392 | -51,824 | 0.01 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 100,591 | 183,741 | +83,150 | 0.01 | 0.02 | +0.01 | buy |
| Senator Investment Group LP | 115,000 | 165,000 | +50,000 | 0.30 | 0.42 | +0.12 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 163,130 | 164,573 | +1,443 | 0.01 | 0.01 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 152,767 | 162,742 | +9,975 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 153,994 | 159,994 | +6,000 | 0.01 | 0.01 | -0.00 | buy |
| Polar Capital Holdings Plc | 1,370,476 | 156,075 | -1,214,401 | 0.51 | 0.05 | -0.46 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 85,000 | 140,000 | +55,000 | 1.10 | 1.13 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 138,519 | 134,131 | -4,388 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 128,621 | 129,359 | +738 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 299,243 | 128,116 | -171,127 | 0.01 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 118,845 | +118,845 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 211,803 | 115,504 | -96,299 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 116,909 | 114,726 | -2,183 | 0.01 | 0.01 | -0.00 | sell |
| Duquesne Family Office LLC | 0 | 114,500 | +114,500 | 0.00 | 0.17 | +0.17 | buy |
| LMR Partners LLP | 86,700 | 101,900 | +15,200 | 0.13 | 0.15 | +0.02 | buy |
| Squarepoint Ops LLC | 101,291 | 101,734 | +443 | 0.02 | 0.02 | -0.00 | buy |
| Woodline Partners LP | 100,000 | 100,007 | +7 | 0.07 | 0.05 | -0.01 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 14,601 | 98,472 | +83,871 | 0.01 | 0.04 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 97,888 | 93,719 | -4,169 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 133,069 | 93,097 | -39,972 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 81,331 | 86,486 | +5,155 | 0.01 | 0.01 | -0.00 | buy |
| Decheng Capital LLC | 0 | 86,363 | +86,363 | 0.00 | 0.65 | +0.65 | buy |
| NORTHERN TRUST CORP | 82,476 | 83,916 | +1,440 | 0.00 | 0.00 | -0.00 | buy |
| Capital International Sarl | 83,001 | 83,001 | 0 | 0.19 | 0.15 | -0.03 | hold |
| Cutter Capital Management, LP | 0 | 79,830 | +79,830 | 0.00 | 1.73 | +1.73 | buy |
| Alberta Investment Management Corp | 62,160 | 79,397 | +17,237 | 0.04 | 0.05 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 60,258 | 69,259 | +9,001 | 0.69 | 0.67 | -0.02 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 63,897 | 57,052 | -6,845 | 2.06 | 2.10 | +0.04 | sell |
| E Fund Management Co., Ltd. | 63,897 | 57,052 | -6,845 | 0.24 | 0.20 | -0.05 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 43,462 | 52,584 | +9,122 | 0.00 | 0.00 | -0.00 | buy |
| AVIVA PLC | 44,000 | 47,000 | +3,000 | 0.01 | 0.01 | -0.00 | buy |
| Korea Investment CORP | 50,890 | 46,990 | -3,900 | 0.01 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 47,606 | 45,790 | -1,816 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 23,808 | 44,653 | +20,845 | 0.00 | 0.00 | +0.00 | buy |
| Old Well Partners, LLC | 42,001 | 42,001 | 0 | 2.35 | 2.10 | -0.26 | hold |
| D. E. Shaw & Co., Inc. | 170,129 | 40,922 | -129,207 | 0.01 | 0.00 | -0.01 | sell |
| TWINBEECH CAPITAL LP | 37,185 | 40,239 | +3,054 | 0.04 | 0.05 | +0.01 | buy |
| CITIGROUP INC | 70,499 | 39,704 | -30,795 | 0.01 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 39,700 | 39,700 | 0 | 0.01 | 0.01 | -0.00 | hold |
| JANE STREET GROUP, LLC | 31,513 | 39,398 | +7,885 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 51,400 | 36,900 | -14,500 | 0.08 | 0.06 | -0.03 | sell |
| HighVista Strategies LLC | 44,305 | 36,385 | -7,920 | 0.97 | 0.73 | -0.24 | sell |
| KEYSTONE INVESTORS PTE LTD | 0 | 35,885 | +35,885 | 0.00 | 0.17 | +0.17 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 34,746 | +34,746 | 0.00 | 0.09 | +0.09 | buy |
| GUGGENHEIM CAPITAL LLC | 31,628 | 33,360 | +1,732 | 0.01 | 0.01 | -0.00 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 28,800 | 28,800 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Aquatic Capital Management LLC | 15,200 | 27,700 | +12,500 | 0.02 | 0.05 | +0.03 | buy |
| Jump Financial, LLC | 121,481 | 26,041 | -95,440 | 0.24 | 0.04 | -0.20 | sell |
| Mirae Asset Global Investments Co., Ltd. | 60,492 | 25,951 | -34,541 | 0.01 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,039 | 24,704 | +6,665 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 25,489 | 24,289 | -1,200 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 22,915 | 23,630 | +715 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 33,164 | 22,791 | -10,373 | 0.06 | 0.03 | -0.02 | sell |
| National Pension Service | 18,130 | 22,574 | +4,444 | 0.00 | 0.00 | +0.00 | buy |