| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,797,994 | 16,147,032 | +3,349,038 | 0.06 | 0.06 | +0.00 | buy |
| CITADEL ADVISORS LLC | 165,931 | 1,144,476 | +978,545 | 0.01 | 0.06 | +0.05 | buy |
| BRAIDWELL LP | 562,600 | 1,243,795 | +681,195 | 1.24 | 2.25 | +1.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,264,707 | 6,861,097 | +596,390 | 5.89 | 4.90 | -0.99 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,776,247 | 2,239,774 | +463,527 | 0.62 | 0.66 | +0.04 | buy |
| Capital International Investors | 1,824,687 | 2,181,074 | +356,387 | 0.02 | 0.02 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,306,391 | 2,614,423 | +308,032 | 0.03 | 0.03 | +0.00 | buy |
| Tri Locum Partners LP | 102,215 | 283,773 | +181,558 | 3.02 | 5.52 | +2.50 | buy |
| JANUS HENDERSON GROUP PLC | 1,865,157 | 2,014,012 | +148,855 | 0.07 | 0.06 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,808,216 | 10,949,120 | +140,904 | 0.09 | 0.08 | -0.01 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 118,845 | +118,845 | 0.00 | 0.01 | +0.01 | buy |
| Duquesne Family Office LLC | 0 | 114,500 | +114,500 | 0.00 | 0.17 | +0.17 | buy |
| BAMCO INC /NY/ | 179,568 | 276,827 | +97,259 | 0.03 | 0.04 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 1,065,889 | 1,158,500 | +92,611 | 0.94 | 0.94 | +0.00 | buy |
| Bellevue Group AG | 201,754 | 293,270 | +91,516 | 0.19 | 0.25 | +0.07 | buy |
| Paradigm Biocapital Advisors LP | 1,894,644 | 1,982,006 | +87,362 | 5.34 | 3.91 | -1.43 | buy |
| Decheng Capital LLC | 0 | 86,363 | +86,363 | 0.00 | 0.65 | +0.65 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 14,601 | 98,472 | +83,871 | 0.01 | 0.04 | +0.03 | buy |
| Russell Investments Group, Ltd. | 100,591 | 183,741 | +83,150 | 0.01 | 0.02 | +0.01 | buy |
| Cutter Capital Management, LP | 0 | 79,830 | +79,830 | 0.00 | 1.73 | +1.73 | buy |
| BANK OF AMERICA CORP /DE/ | 347,589 | 409,553 | +61,964 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 679,076 | 734,293 | +55,217 | 2.45 | 2.05 | -0.40 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 85,000 | 140,000 | +55,000 | 1.10 | 1.13 | +0.03 | buy |
| Senator Investment Group LP | 115,000 | 165,000 | +50,000 | 0.30 | 0.42 | +0.12 | buy |
| KEYSTONE INVESTORS PTE LTD | 0 | 35,885 | +35,885 | 0.00 | 0.17 | +0.17 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 34,746 | +34,746 | 0.00 | 0.09 | +0.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 300,406 | 330,323 | +29,917 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 440,875 | 462,607 | +21,732 | 0.00 | 0.00 | -0.00 | buy |
| Capital International, Inc./CA/ | 432,216 | 453,664 | +21,448 | 0.41 | 0.34 | -0.06 | buy |
| GROUPAMA ASSET MANAGMENT | 0 | 21,422 | +21,422 | 0.00 | 0.02 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 23,808 | 44,653 | +20,845 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 187,385 | 206,507 | +19,122 | 0.01 | 0.01 | -0.00 | buy |
| Alberta Investment Management Corp | 62,160 | 79,397 | +17,237 | 0.04 | 0.05 | +0.01 | buy |
| LMR Partners LLP | 86,700 | 101,900 | +15,200 | 0.13 | 0.15 | +0.02 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 0 | 14,987 | +14,987 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 196,715 | 211,650 | +14,935 | 0.01 | 0.01 | -0.00 | buy |
| Aquatic Capital Management LLC | 15,200 | 27,700 | +12,500 | 0.02 | 0.05 | +0.03 | buy |
| OVERSEA-CHINESE BANKING Corp Ltd | 9,309 | 20,906 | +11,597 | 0.02 | 0.04 | +0.02 | buy |
| STATE STREET CORP | 1,036,745 | 1,048,002 | +11,257 | 0.00 | 0.00 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 152,767 | 162,742 | +9,975 | 0.01 | 0.01 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 9,959 | +9,959 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 43,462 | 52,584 | +9,122 | 0.00 | 0.00 | -0.00 | buy |
| OLD MISSION CAPITAL LLC | 5,171 | 14,230 | +9,059 | 0.01 | 0.02 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 60,258 | 69,259 | +9,001 | 0.69 | 0.67 | -0.02 | buy |
| JANE STREET GROUP, LLC | 31,513 | 39,398 | +7,885 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 492,444 | 499,486 | +7,042 | 0.73 | 0.71 | -0.02 | buy |
| WELLS FARGO & COMPANY/MN | 8,199 | 15,051 | +6,852 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,039 | 24,704 | +6,665 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,222 | 15,292 | +6,070 | 0.11 | 0.11 | +0.00 | buy |
| Swiss National Bank | 153,994 | 159,994 | +6,000 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 81,331 | 86,486 | +5,155 | 0.01 | 0.01 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 4,827 | +4,827 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 4,702 | +4,702 | 0.00 | 0.00 | +0.00 | buy |
| Vident Advisory, LLC | 11,736 | 16,422 | +4,686 | 0.02 | 0.02 | +0.00 | buy |
| DnB Asset Management AS | 0 | 4,589 | +4,589 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 4,570 | +4,570 | 0.00 | 0.02 | +0.02 | buy |
| National Pension Service | 18,130 | 22,574 | +4,444 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 4,226 | +4,226 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL PLC | 14,856 | 18,758 | +3,902 | 0.01 | 0.01 | -0.00 | buy |
| IFM Investors Pty Ltd | 0 | 3,712 | +3,712 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 3,657 | +3,657 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 3,617 | +3,617 | 0.00 | 0.00 | +0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 2,000 | 5,238 | +3,238 | 0.03 | 0.06 | +0.03 | buy |
| TWINBEECH CAPITAL LP | 37,185 | 40,239 | +3,054 | 0.04 | 0.05 | +0.01 | buy |
| AVIVA PLC | 44,000 | 47,000 | +3,000 | 0.01 | 0.01 | -0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,129 | 3,345 | +2,216 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 2,216 | +2,216 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 2,113 | 4,310 | +2,197 | 0.00 | 0.01 | +0.00 | buy |
| Advisors Asset Management, Inc. | 2,499 | 4,494 | +1,995 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 6,040 | 7,904 | +1,864 | 0.07 | 0.06 | -0.01 | buy |
| CI INVESTMENTS INC. | 3,700 | 5,508 | +1,808 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 31,628 | 33,360 | +1,732 | 0.01 | 0.01 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 5,700 | 7,400 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 5,385 | 7,082 | +1,697 | 0.03 | 0.02 | -0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 163,130 | 164,573 | +1,443 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 82,476 | 83,916 | +1,440 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,314 | 6,207 | +893 | 0.20 | 0.18 | -0.02 | buy |
| Chicago Partners Investment Group LLC | 4,217 | 5,018 | +801 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 128,621 | 129,359 | +738 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 22,915 | 23,630 | +715 | 0.00 | 0.00 | -0.00 | buy |
| Parkwood LLC | 12,884 | 13,562 | +678 | 0.12 | 0.08 | -0.04 | buy |
| Legal & General Group Plc | 306,666 | 307,335 | +669 | 0.01 | 0.00 | -0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 1,200 | 1,790 | +590 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 5,832 | 6,359 | +527 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 5,091 | 5,585 | +494 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 101,291 | 101,734 | +443 | 0.02 | 0.02 | -0.00 | buy |
| Clearstead Advisors, LLC | 880 | 1,290 | +410 | 0.00 | 0.00 | -0.00 | buy |
| Asset Management One Co., Ltd. | 9,055 | 9,388 | +333 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 600 | 900 | +300 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 6,542 | 6,835 | +293 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,020 | 1,222 | +202 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 176 | +176 | 0.00 | 0.01 | +0.01 | buy |
| GAMMA Investing LLC | 65 | 178 | +113 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 120 | 223 | +103 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 10,900 | 11,000 | +100 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 4,884 | 4,969 | +85 | 0.01 | 0.01 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,395 | 20,437 | +42 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 25 | 52 | +27 | 0.00 | 0.00 | +0.00 | buy |