| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 562,600 | 1,243,795 | +681,195 | 1.24 | 2.25 | +1.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,776,247 | 2,239,774 | +463,527 | 0.62 | 0.66 | +0.04 | buy |
| Capital International Investors | 1,824,687 | 2,181,074 | +356,387 | 0.02 | 0.02 | +0.00 | buy |
| Tri Locum Partners LP | 102,215 | 283,773 | +181,558 | 3.02 | 5.52 | +2.50 | buy |
| JANUS HENDERSON GROUP PLC | 1,865,157 | 2,014,012 | +148,855 | 0.07 | 0.06 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,808,216 | 10,949,120 | +140,904 | 0.09 | 0.08 | -0.01 | buy |
| BAMCO INC /NY/ | 179,568 | 276,827 | +97,259 | 0.03 | 0.04 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 1,065,889 | 1,158,500 | +92,611 | 0.94 | 0.94 | +0.00 | buy |
| Bellevue Group AG | 201,754 | 293,270 | +91,516 | 0.19 | 0.25 | +0.07 | buy |
| Paradigm Biocapital Advisors LP | 1,894,644 | 1,982,006 | +87,362 | 5.34 | 3.91 | -1.43 | buy |
| PFM Health Sciences, LP | 679,076 | 734,293 | +55,217 | 2.45 | 1.94 | -0.51 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 85,000 | 140,000 | +55,000 | 1.10 | 1.13 | +0.03 | buy |
| Senator Investment Group LP | 115,000 | 165,000 | +50,000 | 0.30 | 0.42 | +0.12 | buy |
| Capital International, Inc./CA/ | 432,216 | 453,664 | +21,448 | 0.41 | 0.34 | -0.06 | buy |
| LMR Partners LLP | 86,700 | 101,900 | +15,200 | 0.13 | 0.15 | +0.02 | buy |
| OVERSEA-CHINESE BANKING Corp Ltd | 9,309 | 20,906 | +11,597 | 0.02 | 0.04 | +0.02 | buy |
| EFG Asset Management (North America) Corp. | 60,258 | 69,259 | +9,001 | 0.69 | 0.67 | -0.02 | buy |
| Rock Springs Capital Management LP | 492,444 | 499,486 | +7,042 | 0.73 | 0.71 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 9,222 | 15,292 | +6,070 | 0.11 | 0.11 | +0.00 | buy |
| Swiss National Bank | 153,994 | 159,994 | +6,000 | 0.01 | 0.01 | -0.00 | buy |
| Vident Advisory, LLC | 11,736 | 16,422 | +4,686 | 0.02 | 0.02 | 0.00 | buy |
| National Pension Service | 18,130 | 22,574 | +4,444 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL PLC | 14,856 | 18,758 | +3,902 | 0.01 | 0.01 | -0.00 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 2,000 | 5,238 | +3,238 | 0.03 | 0.06 | +0.03 | buy |
| TWINBEECH CAPITAL LP | 37,185 | 40,239 | +3,054 | 0.04 | 0.05 | +0.01 | buy |
| AVIVA PLC | 44,000 | 47,000 | +3,000 | 0.01 | 0.01 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 116,909 | 114,726 | +2,183 | 0.01 | 0.01 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 6,040 | 7,904 | +1,864 | 0.07 | 0.06 | -0.01 | buy |
| CI INVESTMENTS INC. | 3,700 | 5,508 | +1,808 | 0.00 | 0.00 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 31,628 | 33,360 | +1,732 | 0.02 | 0.01 | 0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 5,700 | 7,400 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 5,385 | 7,082 | +1,697 | 0.03 | 0.02 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 5,314 | 6,207 | +893 | 0.20 | 0.18 | -0.02 | buy |
| Chicago Partners Investment Group LLC | 4,217 | 5,018 | +801 | 0.01 | 0.01 | -0.00 | buy |
| Parkwood LLC | 12,884 | 13,562 | +678 | 0.09 | 0.07 | -0.02 | buy |
| Legal & General Group Plc | 306,666 | 307,335 | +669 | 0.01 | 0.01 | -0.00 | buy |
| Asset Management One Co., Ltd. | 9,055 | 9,388 | +333 | 0.00 | 0.00 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 10,900 | 11,000 | +100 | 0.00 | 0.00 | -0.00 | buy |
| Bell Investment Advisors, Inc | 120 | 127 | +7 | 0.00 | 0.00 | 0.00 | buy |
| Woodline Partners LP | 100,000 | 100,007 | +7 | 0.07 | 0.05 | -0.01 | buy |
| Krane Funds Advisors LLC | 20,440 | 20,163 | -277 | 0.05 | 0.05 | -0.00 | sell |
| NATIXIS | 2,022 | 1,404 | -618 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 15,701 | 13,569 | -2,132 | 0.00 | 0.00 | -0.00 | sell |
| Korea Investment CORP | 50,890 | 46,990 | -3,900 | 0.01 | 0.01 | -0.00 | sell |
| E Fund Management Co., Ltd. | 63,897 | 57,052 | -6,845 | 0.24 | 0.20 | -0.05 | sell |
| E Fund Management (Hong Kong) Co., Ltd. | 63,897 | 57,052 | -6,845 | 2.06 | 2.10 | +0.04 | sell |
| HighVista Strategies LLC | 44,305 | 36,385 | -7,920 | 0.97 | 0.73 | -0.24 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 16,000 | 6,000 | -10,000 | 0.09 | 0.02 | -0.07 | sell |
| BI Asset Management Fondsmaeglerselskab A/S | 18,588 | 3,318 | -15,270 | 0.02 | 0.00 | -0.02 | sell |
| Avidity Partners Management LP | 685,000 | 668,300 | -16,700 | 1.58 | 1.33 | -0.24 | sell |
| ArrowMark Colorado Holdings LLC | 1,064,542 | 1,046,739 | -17,803 | 0.71 | 0.66 | -0.05 | sell |
| Candriam S.C.A. | 241,032 | 221,032 | -20,000 | 0.10 | 0.08 | -0.02 | sell |
| Nicholas Investment Partners, LP | 26,650 | 5,976 | -20,674 | 0.19 | 0.03 | -0.15 | sell |
| Artisan Partners Limited Partnership | 517,837 | 492,099 | -25,738 | 0.05 | 0.04 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 238,216 | 186,392 | -51,824 | 0.01 | 0.01 | -0.00 | sell |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 809,574 | 751,935 | -57,639 | 6.84 | 8.31 | +1.46 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,984,826 | 1,890,796 | -94,030 | 0.04 | 0.03 | -0.01 | sell |
| Bridgewater Associates, LP | 330,091 | 208,900 | -121,191 | 0.11 | 0.06 | -0.05 | sell |
| First Turn Management, LLC | 476,079 | 228,251 | -247,828 | 4.11 | 1.92 | -2.20 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 566,023 | 235,493 | -330,530 | 1.41 | 0.45 | -0.96 | sell |
| Holocene Advisors, LP | 1,760,697 | 761,626 | -999,071 | 0.41 | 0.16 | -0.26 | sell |
| Polar Capital Holdings Plc | 1,370,476 | 156,075 | -1,214,401 | 0.51 | 0.05 | -0.46 | sell |