| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,147,032 | 17,621,599 | +1,474,567 | 0.06 | 0.05 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,949,120 | 11,489,275 | +540,155 | 0.08 | 0.06 | -0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,861,097 | 7,506,934 | +645,837 | 4.90 | 4.40 | -0.50 | buy |
| HHLR ADVISORS, LTD. | 5,984,550 | 6,636,496 | +651,946 | 7.29 | 7.25 | -0.04 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,239,774 | 4,772,209 | +2,532,435 | 0.66 | 1.04 | +0.38 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,614,423 | 2,809,368 | +194,945 | 0.03 | 0.02 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,014,012 | 2,359,056 | +345,044 | 0.06 | 0.06 | -0.01 | buy |
| Capital International Investors | 2,181,074 | 2,162,711 | -18,363 | 0.02 | 0.02 | -0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,890,796 | 1,960,709 | +69,913 | 0.03 | 0.03 | -0.01 | buy |
| BRAIDWELL LP | 1,243,795 | 1,669,720 | +425,925 | 2.25 | 2.32 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 371,091 | 1,658,681 | +1,287,590 | 0.02 | 0.06 | +0.04 | buy |
| FEDERATED HERMES, INC. | 1,537,060 | 1,541,345 | +4,285 | 0.20 | 0.16 | -0.04 | buy |
| CITADEL ADVISORS LLC | 1,144,476 | 1,444,863 | +300,387 | 0.06 | 0.06 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,982,006 | 1,203,308 | -778,698 | 3.91 | 2.04 | -1.87 | sell |
| TimesSquare Capital Management, LLC | 1,158,500 | 1,173,766 | +15,266 | 0.94 | 0.82 | -0.13 | buy |
| STATE STREET CORP | 1,048,002 | 1,135,487 | +87,485 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,113,158 | 1,087,849 | -25,309 | 0.02 | 0.02 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 1,046,739 | 1,062,734 | +15,995 | 0.66 | 0.56 | -0.10 | buy |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 751,935 | 1,022,780 | +270,845 | 8.31 | 9.86 | +1.55 | buy |
| JOHNSON & JOHNSON | 814,586 | 814,586 | 0 | 1.04 | 9.00 | +7.97 | hold |
| GOLDMAN SACHS GROUP INC | 310,408 | 667,990 | +357,582 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 93,719 | 657,387 | +563,668 | 0.00 | 0.01 | +0.01 | buy |
| Capital International, Inc./CA/ | 453,664 | 531,660 | +77,996 | 0.34 | 0.31 | -0.03 | buy |
| Rock Springs Capital Management LP | 499,486 | 505,786 | +6,300 | 0.71 | 0.68 | -0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 462,607 | 477,527 | +14,920 | 0.00 | 0.00 | -0.00 | buy |
| Artisan Partners Limited Partnership | 492,099 | 476,615 | -15,484 | 0.04 | 0.03 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 451,965 | +451,965 | 0.00 | 0.05 | +0.05 | buy |
| Avidity Partners Management LP | 668,300 | 398,000 | -270,300 | 1.33 | 0.75 | -0.58 | sell |
| MORGAN STANLEY | 342,033 | 375,220 | +33,187 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 293,270 | 369,270 | +76,000 | 0.25 | 0.27 | +0.01 | buy |
| Tri Locum Partners LP | 283,773 | 356,532 | +72,759 | 5.52 | 3.99 | -1.53 | buy |
| JPMORGAN CHASE & CO | 397,199 | 355,948 | -41,251 | 0.00 | 0.00 | -0.00 | sell |
| Cutter Capital Management, LP | 79,830 | 343,130 | +263,300 | 1.73 | 4.63 | +2.90 | buy |
| BANK OF AMERICA CORP /DE/ | 409,553 | 321,743 | -87,810 | 0.00 | 0.00 | -0.00 | sell |
| BAMCO INC /NY/ | 276,827 | 309,264 | +32,437 | 0.04 | 0.04 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 304,520 | +304,520 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 307,335 | 302,197 | -5,138 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 221,032 | 261,035 | +40,003 | 0.08 | 0.07 | -0.01 | buy |
| Magnetar Financial LLC | 0 | 251,667 | +251,667 | 0.00 | 0.23 | +0.23 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 14,987 | 238,600 | +223,613 | 0.00 | 0.01 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 36,900 | 235,059 | +198,159 | 0.06 | 0.27 | +0.21 | buy |
| HSBC HOLDINGS PLC | 211,650 | 232,560 | +20,910 | 0.01 | 0.01 | -0.00 | buy |
| Polar Capital Holdings Plc | 156,075 | 206,632 | +50,557 | 0.05 | 0.05 | +0.01 | buy |
| BARCLAYS PLC | 206,507 | 196,013 | -10,494 | 0.01 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 0 | 195,000 | +195,000 | 0.00 | 5.15 | +5.15 | buy |
| Russell Investments Group, Ltd. | 183,741 | 184,393 | +652 | 0.02 | 0.01 | -0.00 | buy |
| Bridgewater Associates, LP | 208,900 | 165,459 | -43,441 | 0.06 | 0.04 | -0.02 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 164,573 | 162,555 | -2,018 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 159,994 | 159,994 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Senator Investment Group LP | 165,000 | 155,000 | -10,000 | 0.42 | 0.33 | -0.09 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 154,665 | +154,665 | 0.00 | 8.64 | +8.64 | buy |
| CenterBook Partners LP | 0 | 154,074 | +154,074 | 0.00 | 0.42 | +0.42 | buy |
| TD ASSET MANAGEMENT INC | 186,392 | 140,992 | -45,400 | 0.01 | 0.01 | -0.00 | sell |
| Walleye Capital LLC | 2,216 | 134,978 | +132,762 | 0.00 | 0.06 | +0.06 | buy |
| LMR Partners LLP | 101,900 | 127,000 | +25,100 | 0.15 | 0.12 | -0.03 | buy |
| VANGUARD GROUP INC | 129,359 | 123,739 | -5,620 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 134,131 | 120,632 | -13,499 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 128,116 | 119,639 | -8,477 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 114,726 | 112,789 | -1,937 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 93,097 | 110,259 | +17,162 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 330,323 | 106,533 | -223,790 | 0.01 | 0.00 | -0.01 | sell |
| Woodline Partners LP | 100,007 | 100,001 | -6 | 0.05 | 0.04 | -0.01 | sell |
| Decheng Capital LLC | 86,363 | 98,558 | +12,195 | 0.65 | 1.34 | +0.69 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 98,472 | 98,136 | -336 | 0.04 | 0.02 | -0.01 | sell |
| Capital International Sarl | 83,001 | 93,786 | +10,785 | 0.15 | 0.13 | -0.03 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 118,845 | 87,792 | -31,053 | 0.01 | 0.01 | -0.01 | sell |
| Pictet Asset Management Holding SA | 86,486 | 87,322 | +836 | 0.01 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 552,413 | 86,410 | -466,003 | 0.03 | 0.00 | -0.03 | sell |
| NORTHERN TRUST CORP | 83,916 | 83,912 | -4 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 39,398 | 82,541 | +43,143 | 0.00 | 0.00 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 69,259 | 71,079 | +1,820 | 0.67 | 0.55 | -0.13 | buy |
| Squarepoint Ops LLC | 101,734 | 69,400 | -32,334 | 0.02 | 0.01 | -0.01 | sell |
| Alberta Investment Management Corp | 79,397 | 61,865 | -17,532 | 0.05 | 0.03 | -0.02 | sell |
| Cubist Systematic Strategies, LLC | 0 | 59,163 | +59,163 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 59,073 | +59,073 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 57,052 | 58,426 | +1,374 | 2.10 | 1.59 | -0.51 | buy |
| E Fund Management Co., Ltd. | 57,052 | 58,426 | +1,374 | 0.20 | 0.14 | -0.06 | buy |
| Empire Life Investments Inc. | 0 | 56,320 | +56,320 | 0.00 | 0.16 | +0.16 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 52,584 | 55,402 | +2,818 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 55,000 | +55,000 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 0 | 53,340 | +53,340 | 0.00 | 0.04 | +0.04 | buy |
| AVIVA PLC | 47,000 | 47,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Handelsbanken Fonder AB | 39,700 | 46,900 | +7,200 | 0.01 | 0.01 | -0.00 | buy |
| SEI INVESTMENTS CO | 45,790 | 46,492 | +702 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 26,041 | 46,154 | +20,113 | 0.04 | 0.04 | +0.00 | buy |
| CITIGROUP INC | 39,704 | 43,480 | +3,776 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 25,951 | 41,700 | +15,749 | 0.00 | 0.01 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 33,360 | 36,390 | +3,030 | 0.01 | 0.01 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,704 | 31,070 | +6,366 | 0.00 | 0.00 | -0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 30,000 | +30,000 | 0.00 | 0.27 | +0.27 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 29,905 | +29,905 | 0.00 | 0.04 | +0.04 | buy |
| Old Well Partners, LLC | 42,001 | 29,301 | -12,700 | 2.10 | 1.53 | -0.57 | sell |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 28,800 | 28,800 | 0 | 0.01 | 0.01 | -0.00 | hold |
| GROUP ONE TRADING LLC | 0 | 28,215 | +28,215 | 0.00 | 0.04 | +0.04 | buy |
| OVERSEA-CHINESE BANKING Corp Ltd | 20,906 | 27,154 | +6,248 | 0.04 | 0.04 | -0.00 | buy |
| RHUMBLINE ADVISERS | 23,630 | 26,334 | +2,704 | 0.00 | 0.00 | -0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 24,289 | 24,689 | +400 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 115,504 | 23,046 | -92,458 | 0.00 | 0.00 | -0.00 | sell |
| GROUPAMA ASSET MANAGMENT | 21,422 | 22,782 | +1,360 | 0.02 | 0.01 | -0.01 | buy |
| National Pension Service | 22,574 | 22,574 | 0 | 0.00 | 0.00 | -0.00 | hold |