| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,204,213 | 25,670,311 | +12,466,098 | 0.03 | 0.05 | +0.02 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 6,917,567 | 6,472,547 | -445,020 | 1.14 | 0.96 | -0.18 | sell |
| HHLR ADVISORS, LTD. | 5,984,550 | 5,984,550 | 0 | 5.74 | 6.84 | +1.10 | hold |
| BlackRock, Inc. | 4,527,000 | 4,248,568 | -278,432 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,749,965 | 3,774,009 | +24,044 | 5.15 | 5.05 | -0.10 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,743,555 | 2,962,338 | +1,218,783 | 1.17 | 1.91 | +0.74 | buy |
| BRAIDWELL LP | 2,977,951 | 2,542,104 | -435,847 | 3.55 | 3.09 | -0.47 | sell |
| Artisan Partners Limited Partnership | 1,131,768 | 2,122,268 | +990,500 | 0.06 | 0.11 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 2,057,804 | 2,092,732 | +34,928 | 0.04 | 0.04 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,508,252 | 1,560,596 | +52,344 | 0.02 | 0.02 | -0.00 | buy |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 1,101,887 | 1,293,052 | +191,165 | 7.72 | 10.56 | +2.84 | buy |
| STATE STREET CORP | 1,138,189 | 1,119,691 | -18,498 | 0.00 | 0.00 | -0.00 | sell |
| Capital International Investors | 1,677,260 | 1,082,473 | -594,787 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,391,671 | 1,063,724 | -327,947 | 0.10 | 0.07 | -0.03 | sell |
| UBS Group AG | 961,175 | 1,021,556 | +60,381 | 0.01 | 0.01 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 1,131,105 | 983,510 | -147,595 | 0.62 | 0.63 | +0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 200,991 | 947,633 | +746,642 | 0.02 | 0.08 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 953,831 | 941,916 | -11,915 | 0.01 | 0.01 | -0.00 | sell |
| IvyRock Asset Management (HK) Ltd | 844,000 | 869,900 | +25,900 | 13.46 | 14.25 | +0.79 | buy |
| TANG CAPITAL MANAGEMENT LLC | 830,000 | 830,000 | 0 | 1.56 | 1.49 | -0.07 | hold |
| JOHNSON & JOHNSON | 814,586 | 814,586 | 0 | 8.08 | 8.44 | +0.36 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,729,779 | 800,220 | -5,929,559 | 0.03 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 858,489 | 740,847 | -117,642 | 0.03 | 0.02 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 504,100 | 716,100 | +212,000 | 0.04 | 0.05 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 710,900 | 656,300 | -54,600 | 0.04 | 0.03 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 657,148 | 628,185 | -28,963 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 1,132,116 | 518,289 | -613,827 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 429,589 | 476,247 | +46,658 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 522,791 | 473,742 | -49,049 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,270,264 | 445,529 | -1,824,735 | 0.03 | 0.01 | -0.02 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 444,900 | +444,900 | 0.00 | 0.01 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 138,240 | 350,000 | +211,760 | 2.55 | 8.08 | +5.53 | buy |
| JPMORGAN CHASE & CO | 318,943 | 304,321 | -14,622 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 298,653 | 287,039 | -11,614 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 259,352 | 286,500 | +27,148 | 0.00 | 0.00 | +0.00 | buy |
| Empire Life Investments Inc. | 165,661 | 277,927 | +112,266 | 0.37 | 0.63 | +0.26 | buy |
| STEMPOINT CAPITAL LP | 0 | 270,144 | +270,144 | 0.00 | 3.09 | +3.09 | buy |
| TWO SIGMA INVESTMENTS, LP | 801,781 | 269,701 | -532,080 | 0.06 | 0.02 | -0.04 | sell |
| Candriam S.C.A. | 221,832 | 261,815 | +39,983 | 0.05 | 0.05 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 168,279 | 255,986 | +87,707 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 286,621 | 255,381 | -31,240 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 0 | 250,000 | +250,000 | 0.00 | 1.19 | +1.19 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,199 | 246,146 | +146,947 | 0.01 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 227,906 | +227,906 | 0.00 | 0.02 | +0.02 | buy |
| Evergreen Quality Fund GP, Ltd. | 0 | 218,700 | +218,700 | 0.00 | 0.24 | +0.24 | buy |
| Woodline Partners LP | 113,971 | 205,077 | +91,106 | 0.03 | 0.04 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 228,693 | 195,060 | -33,633 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 234,460 | 191,731 | -42,729 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 228,000 | 190,017 | -37,983 | 0.01 | 0.01 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 177,369 | 178,012 | +643 | 0.30 | 0.26 | -0.04 | buy |
| Tri Locum Partners LP | 0 | 173,260 | +173,260 | 0.00 | 1.87 | +1.87 | buy |
| CITADEL ADVISORS LLC | 155,174 | 165,061 | +9,887 | 0.01 | 0.01 | -0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 173,766 | 162,609 | -11,157 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 36,987 | 162,055 | +125,068 | 0.22 | 0.90 | +0.68 | buy |
| Capital International, Inc./CA/ | 271,127 | 157,896 | -113,231 | 0.11 | 0.05 | -0.06 | sell |
| Hudson Bay Capital Management LP | 175,000 | 154,500 | -20,500 | 0.04 | 0.04 | -0.00 | sell |
| Squarepoint Ops LLC | 83,725 | 148,681 | +64,956 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 113,455 | 146,322 | +32,867 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 167,394 | 145,694 | -21,700 | 0.00 | 0.00 | -0.00 | sell |
| iA Global Asset Management Inc. | 168,561 | 140,418 | -28,143 | 0.10 | 0.07 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 138,656 | 123,977 | -14,679 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Europe (London) LLP | 0 | 122,274 | +122,274 | 0.00 | 0.22 | +0.22 | buy |
| VANGUARD GROUP INC | 135,506 | 122,032 | -13,474 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 134,226 | 122,007 | -12,219 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 59,276 | 118,774 | +59,498 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 170,186 | 115,986 | -54,200 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 18,712 | 107,700 | +88,988 | 0.02 | 0.10 | +0.07 | buy |
| Triata Capital Ltd | 0 | 107,500 | +107,500 | 0.00 | 0.74 | +0.74 | buy |
| CenterBook Partners LP | 74,879 | 105,668 | +30,789 | 0.16 | 0.21 | +0.05 | buy |
| TD ASSET MANAGEMENT INC | 94,192 | 103,392 | +9,200 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 47,941 | 100,203 | +52,262 | 0.03 | 0.05 | +0.02 | buy |
| Pictet Asset Management Holding SA | 182,353 | 98,397 | -83,956 | 0.01 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 40,906 | 94,124 | +53,218 | 0.00 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 91,191 | 85,438 | -5,753 | 0.07 | 0.07 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,310 | 84,081 | +11,771 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 0 | 80,000 | +80,000 | 0.00 | 0.04 | +0.04 | buy |
| Sterling Capital Management LLC | 75,340 | 75,347 | +7 | 0.04 | 0.04 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 55,610 | 74,751 | +19,141 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,827 | 68,607 | +52,780 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 72,202 | 61,636 | -10,566 | 0.01 | 0.00 | -0.00 | sell |
| ROYAL LONDON ASSET MANAGEMENT LTD | 59,600 | 60,800 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 303,330 | 60,713 | -242,617 | 0.01 | 0.00 | -0.01 | sell |
| LMR Partners LLP | 0 | 60,000 | +60,000 | 0.00 | 0.03 | +0.03 | buy |
| NEOS Investment Management LLC | 52,008 | 56,688 | +4,680 | 0.03 | 0.02 | -0.01 | buy |
| TEMA ETFS LLC | 52,008 | 56,688 | +4,680 | 0.53 | 0.53 | +0.01 | buy |
| Polar Capital Holdings Plc | 175,123 | 51,195 | -123,928 | 0.04 | 0.01 | -0.03 | sell |
| Resolute Capital Asset Partners LLC | 60,000 | 50,963 | -9,037 | 1.15 | 0.95 | -0.20 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 39,537 | 50,056 | +10,519 | 0.06 | 0.07 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 72,060 | 49,505 | -22,555 | 0.02 | 0.01 | -0.01 | sell |
| AVIVA PLC | 49,149 | 46,190 | -2,959 | 0.00 | 0.00 | -0.00 | sell |
| Diversified Trust Co | 46,151 | 45,771 | -380 | 0.04 | 0.04 | -0.00 | sell |
| SEI INVESTMENTS CO | 68,028 | 43,992 | -24,036 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 12,954 | 43,308 | +30,354 | 0.00 | 0.00 | +0.00 | buy |
| OPTIMAS CAPITAL Ltd | 0 | 43,300 | +43,300 | 0.00 | 1.62 | +1.62 | buy |
| CITIGROUP INC | 38,163 | 42,346 | +4,183 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 15,032 | 38,818 | +23,786 | 0.01 | 0.02 | +0.01 | buy |
| PRUDENTIAL PLC | 36,959 | 36,959 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Symmetry Investments LP | 0 | 36,200 | +36,200 | 0.00 | 0.11 | +0.11 | buy |
| ROYAL BANK OF CANADA | 0 | 35,321 | +35,321 | 0.00 | 0.00 | +0.00 | buy |
| Krane Funds Advisors LLC | 39,080 | 34,161 | -4,919 | 0.04 | 0.05 | +0.01 | sell |