| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,743,555 | 2,962,338 | +1,218,783 | 1.17 | 1.91 | +0.74 | buy |
| Artisan Partners Limited Partnership | 1,131,768 | 2,122,268 | +990,500 | 0.06 | 0.11 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 801,781 | 269,701 | +532,080 | 0.06 | 0.02 | 0.00 | sell |
| GREAT POINT PARTNERS LLC | 138,240 | 350,000 | +211,760 | 2.48 | 8.08 | +5.59 | buy |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 1,101,887 | 1,293,052 | +191,165 | 7.72 | 10.56 | +2.84 | buy |
| Polymer Capital Management (HK) LTD | 36,987 | 162,055 | +125,068 | 0.22 | 0.90 | +0.68 | buy |
| Empire Life Investments Inc. | 165,661 | 277,927 | +112,266 | 0.37 | 0.63 | +0.26 | buy |
| Woodline Partners LP | 113,971 | 205,077 | +91,106 | 0.03 | 0.04 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 18,712 | 107,700 | +88,988 | 0.01 | 0.06 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 710,900 | 656,300 | +54,600 | 0.04 | 0.03 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 40,906 | 94,124 | +53,218 | 0.00 | 0.01 | 0.00 | buy |
| Candriam S.C.A. | 221,832 | 261,815 | +39,983 | 0.05 | 0.05 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 228,000 | 190,017 | +37,983 | 0.01 | 0.01 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 2,057,804 | 2,092,732 | +34,928 | 0.04 | 0.04 | 0.00 | buy |
| CenterBook Partners LP | 74,879 | 105,668 | +30,789 | 0.16 | 0.21 | +0.05 | buy |
| IvyRock Asset Management (HK) Ltd | 844,000 | 869,900 | +25,900 | 13.46 | 14.25 | +0.79 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,749,965 | 3,774,009 | +24,044 | 4.72 | 4.04 | -0.68 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 39,537 | 50,056 | +10,519 | 0.06 | 0.07 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 94,192 | 103,392 | +9,200 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 52,008 | 56,688 | +4,680 | 0.03 | 0.02 | -0.01 | buy |
| TEMA ETFS LLC | 52,008 | 56,688 | +4,680 | 0.53 | 0.53 | +0.01 | buy |
| Resona Asset Management Co.,Ltd. | 17,450 | 21,901 | +4,451 | 0.00 | 0.00 | +0.00 | buy |
| Korea Investment CORP | 5,790 | 9,790 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 19,825 | 23,720 | +3,895 | 0.01 | 0.02 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 34,607 | 32,587 | +2,020 | 0.01 | 0.01 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 10,116 | 11,722 | +1,606 | 0.09 | 0.14 | +0.05 | buy |
| ROYAL LONDON ASSET MANAGEMENT LTD | 59,600 | 60,800 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 177,369 | 178,012 | +643 | 0.30 | 0.26 | -0.04 | buy |
| Quarry LP | 1,400 | 2,000 | +600 | 0.01 | 0.02 | 0.00 | buy |
| NATIXIS | 785 | 720 | +65 | 0.00 | 0.00 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 16,385 | 16,406 | +21 | 0.05 | 0.05 | +0.00 | buy |
| J.Safra Asset Management Corp | 192 | 201 | +9 | 0.00 | 0.00 | -0.00 | buy |
| Diversified Trust Co | 46,151 | 45,771 | -380 | 0.04 | 0.04 | -0.00 | sell |
| Asset Management One Co., Ltd. | 11,085 | 10,575 | -510 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 14,786 | 14,148 | -638 | 0.00 | 0.00 | -0.00 | sell |
| Allostery Investments LP | 4,750 | 4,000 | -750 | 0.23 | 1.81 | +1.58 | sell |
| OFI INVEST ASSET MANAGEMENT | 1,712 | 606 | -1,106 | 0.00 | 0.00 | -0.00 | sell |
| AVIVA PLC | 49,149 | 46,190 | -2,959 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 14,902 | 11,802 | -3,100 | 0.02 | 0.01 | -0.00 | sell |
| E Fund Management (Hong Kong) Co., Ltd. | 29,928 | 26,132 | -3,796 | 0.91 | 0.89 | -0.02 | sell |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 28,800 | 25,000 | -3,800 | 0.01 | 0.01 | -0.00 | sell |
| Krane Funds Advisors LLC | 39,080 | 34,161 | -4,919 | 0.04 | 0.05 | +0.01 | sell |
| Bellevue Group AG | 91,191 | 85,438 | -5,753 | 0.07 | 0.07 | -0.00 | sell |
| Capital International Sarl | 35,093 | 27,758 | -7,335 | 0.03 | 0.02 | -0.01 | sell |
| Resolute Capital Asset Partners LLC | 60,000 | 50,963 | -9,037 | 1.15 | 0.95 | -0.20 | sell |
| Lansforsakringar Fondforvaltning AB (publ) | 27,810 | 12,000 | -15,810 | 0.01 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 35,965 | 19,627 | -16,338 | 0.95 | 0.46 | -0.49 | sell |
| iA Global Asset Management Inc. | 168,561 | 140,418 | -28,143 | 0.10 | 0.07 | -0.02 | sell |
| E Fund Management Co., Ltd. | 100,170 | 26,132 | -74,038 | 0.16 | 0.04 | -0.12 | sell |
| Decheng Capital LLC | 100,000 | 20,000 | -80,000 | 0.95 | 0.18 | -0.77 | sell |
| Capital International, Inc./CA/ | 271,127 | 157,896 | -113,231 | 0.11 | 0.05 | -0.06 | sell |
| Alberta Investment Management Corp | 128,288 | 8,500 | -119,788 | 0.03 | 0.00 | -0.03 | sell |
| Polar Capital Holdings Plc | 175,123 | 51,195 | -123,928 | 0.04 | 0.01 | -0.03 | sell |
| ArrowMark Colorado Holdings LLC | 1,131,105 | 983,510 | -147,595 | 0.62 | 0.63 | +0.01 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 303,330 | 60,713 | -242,617 | 0.01 | 0.00 | -0.01 | sell |
| BRAIDWELL LP | 2,977,951 | 2,542,104 | -435,847 | 3.55 | 3.09 | -0.47 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 6,917,567 | 6,472,547 | -445,020 | 1.14 | 0.96 | -0.18 | sell |
| Capital International Investors | 1,677,260 | 1,082,473 | -594,787 | 0.01 | 0.01 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,270,264 | 445,529 | -1,824,735 | 0.03 | 0.01 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,729,779 | 800,220 | -5,929,559 | 0.03 | 0.00 | -0.03 | sell |