| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 25,696,740 | 29,093,899 | +3,397,159 | 0.02 | 0.04 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,687,638 | 8,137,638 | +450,000 | 1.64 | 2.45 | +0.81 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,581,029 | 7,070,000 | -511,029 | 3.72 | 4.29 | +0.57 | sell |
| HHLR ADVISORS, LTD. | 5,984,550 | 5,984,550 | 0 | 6.47 | 20.77 | +14.30 | hold |
| BlackRock, Inc. | 4,684,543 | 4,726,534 | +41,991 | 0.00 | 0.00 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,763,475 | 4,430,063 | -1,333,412 | 0.44 | 0.42 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 1,464,112 | 3,662,315 | +2,198,203 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 3,886,017 | 3,076,124 | -809,893 | 0.12 | 0.14 | +0.01 | sell |
| Kynam Capital Management, LP | 1,576,295 | 3,001,205 | +1,424,910 | 1.81 | 4.79 | +2.98 | buy |
| Assenagon Asset Management S.A. | 0 | 1,915,056 | +1,915,056 | 0.00 | 0.07 | +0.07 | buy |
| Artisan Partners Limited Partnership | 2,254,488 | 1,559,441 | -695,047 | 0.07 | 0.07 | +0.01 | sell |
| STATE STREET CORP | 1,498,372 | 1,498,704 | +332 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Investors | 647,850 | 1,420,654 | +772,804 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 603,247 | 1,394,531 | +791,284 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 1,205,000 | +1,205,000 | 0.00 | 1.20 | +1.20 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 1,158,808 | +1,158,808 | 0.00 | 0.19 | +0.19 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 521,800 | 1,000,200 | +478,400 | 0.01 | 0.04 | +0.03 | buy |
| Ghisallo Capital Management LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.57 | +0.57 | buy |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 925,920 | 917,266 | -8,654 | 6.80 | 9.08 | +2.29 | sell |
| JOHNSON & JOHNSON | 814,586 | 814,586 | 0 | 2.26 | 2.95 | +0.69 | hold |
| IvyRock Asset Management (HK) Ltd | 804,000 | 801,000 | -3,000 | 8.17 | 13.08 | +4.90 | sell |
| EcoR1 Capital, LLC | 0 | 800,000 | +800,000 | 0.00 | 1.15 | +1.15 | buy |
| Squarepoint Ops LLC | 479,480 | 769,252 | +289,772 | 0.02 | 0.04 | +0.02 | buy |
| JPMORGAN CHASE & CO | 288,103 | 766,364 | +478,261 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 406,901 | 759,994 | +353,093 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 205,870 | 663,086 | +457,216 | 0.01 | 0.06 | +0.05 | buy |
| Triata Capital Ltd | 629,914 | 629,914 | 0 | 2.07 | 3.09 | +1.03 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 600,000 | +600,000 | 0.00 | 0.02 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 574,898 | 574,685 | -213 | 0.00 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 550,051 | 563,489 | +13,438 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 470,292 | 504,924 | +34,632 | 0.04 | 0.07 | +0.02 | buy |
| UBS Group AG | 305,214 | 502,466 | +197,252 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 204,603 | 452,907 | +248,304 | 0.20 | 0.64 | +0.44 | buy |
| ArrowMark Colorado Holdings LLC | 727,144 | 362,781 | -364,363 | 0.35 | 0.44 | +0.09 | sell |
| Hudson Bay Capital Management LP | 876,351 | 340,000 | -536,351 | 0.10 | 0.05 | -0.05 | sell |
| Alyeska Investment Group, L.P. | 10,506 | 307,474 | +296,968 | 0.00 | 0.02 | +0.02 | buy |
| Empire Life Investments Inc. | 300,958 | 296,586 | -4,372 | 0.35 | 0.48 | +0.13 | sell |
| NORTHERN TRUST CORP | 280,226 | 274,856 | -5,370 | 0.00 | 0.00 | +0.00 | sell |
| Resolute Capital Asset Partners LLC | 0 | 260,871 | +260,871 | 0.00 | 3.22 | +3.22 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 234,533 | 251,449 | +16,916 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 250,000 | +250,000 | 0.00 | 0.26 | +0.26 | buy |
| AMERIPRISE FINANCIAL INC | 75,439 | 249,767 | +174,328 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 15,295 | 247,902 | +232,607 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 179,453 | 240,476 | +61,023 | 0.01 | 0.02 | +0.01 | buy |
| HSBC HOLDINGS PLC | 221,475 | 236,204 | +14,729 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 228,229 | +228,229 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 233,868 | 227,867 | -6,001 | 0.00 | 0.00 | +0.00 | sell |
| Longaeva Partners L.P. | 0 | 214,355 | +214,355 | 0.00 | 0.18 | +0.18 | buy |
| iA Global Asset Management Inc. | 230,587 | 211,135 | -19,452 | 0.06 | 0.07 | +0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 210,996 | +210,996 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 287,123 | 202,227 | -84,896 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 177,862 | 195,636 | +17,774 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 179,900 | 175,322 | -4,578 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 165,020 | 173,993 | +8,973 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 166,590 | 173,561 | +6,971 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 165,209 | +165,209 | 0.00 | 0.48 | +0.48 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,890,396 | 163,903 | -1,726,493 | 0.03 | 0.00 | -0.02 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88,564 | 159,419 | +70,855 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 142,794 | 138,294 | -4,500 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 163,148 | 135,404 | -27,744 | 0.00 | 0.00 | +0.00 | sell |
| Rockefeller Capital Management L.P. | 83,178 | 134,864 | +51,686 | 0.00 | 0.01 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 138,046 | 130,704 | -7,342 | 0.03 | 0.04 | +0.01 | sell |
| Nuveen, LLC | 96,786 | 115,112 | +18,326 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 29,922 | 109,327 | +79,405 | 0.02 | 0.07 | +0.05 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 104,994 | +104,994 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 97,613 | 104,765 | +7,152 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 96,781 | 97,113 | +332 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 535,658 | 96,640 | -439,018 | 0.01 | 0.00 | -0.01 | sell |
| Pictet Asset Management Holding SA | 98,721 | 94,397 | -4,324 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 208,207 | 88,106 | -120,101 | 0.07 | 0.03 | -0.03 | sell |
| Monashee Investment Management LLC | 0 | 85,385 | +85,385 | 0.00 | 4.14 | +4.14 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 82,015 | +82,015 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 37,787 | 81,596 | +43,809 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 140,000 | 80,000 | -60,000 | 0.03 | 0.03 | -0.01 | sell |
| Creative Planning | 55,017 | 79,946 | +24,929 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL LONDON ASSET MANAGEMENT LTD | 75,000 | 75,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 25,865 | 70,017 | +44,152 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,195 | 62,746 | +47,551 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 79,949 | 56,247 | -23,702 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 55,533 | +55,533 | 0.00 | 0.03 | +0.03 | buy |
| AVIVA PLC | 54,113 | 53,486 | -627 | 0.00 | 0.00 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 46,856 | +46,856 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 18,400 | 45,400 | +27,000 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 42,000 | 41,500 | -500 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 41,384 | +41,384 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 0 | 35,400 | +35,400 | 0.00 | 0.19 | +0.19 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 182,364 | 35,348 | -147,016 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 516,980 | 34,141 | -482,839 | 0.01 | 0.00 | -0.01 | sell |
| Rock Springs Capital Management LP | 40,500 | 33,500 | -7,000 | 0.04 | 0.05 | +0.00 | sell |
| Bellevue Group AG | 35,886 | 33,054 | -2,832 | 0.02 | 0.02 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 42,727 | 32,467 | -10,260 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 37,824 | 32,419 | -5,405 | 0.19 | 0.22 | +0.03 | sell |
| ROYAL BANK OF CANADA | 24,261 | 32,184 | +7,923 | 0.00 | 0.00 | +0.00 | buy |
| Krane Funds Advisors LLC | 31,538 | 31,488 | -50 | 0.02 | 0.03 | +0.01 | sell |
| Aberdeen Group plc | 29,655 | 30,608 | +953 | 0.00 | 0.00 | +0.00 | buy |
| COOKSON PEIRCE & CO INC | 0 | 30,000 | +30,000 | 0.00 | 0.03 | +0.03 | buy |
| TUDOR INVESTMENT CORP ET AL | 55,102 | 29,066 | -26,036 | 0.01 | 0.00 | -0.00 | sell |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 28,600 | 28,600 | 0 | 0.00 | 0.01 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1,527,336 | 28,596 | -1,498,740 | 0.04 | 0.00 | -0.04 | sell |
| E Fund Management (Hong Kong) Co., Ltd. | 29,922 | 28,209 | -1,713 | 0.25 | 0.27 | +0.02 | sell |