| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 848,100 | 1,708,510 | +860,410 | 0.13 | 0.26 | +0.13 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 972,054 | 1,668,150 | +696,096 | 0.43 | 0.76 | +0.34 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,031,324 | 9,693,368 | +662,044 | 0.09 | 0.10 | +0.01 | buy |
| Holocene Advisors, LP | 907,053 | 1,269,264 | +362,211 | 0.27 | 0.38 | +0.11 | buy |
| BRAIDWELL LP | 556,301 | 879,564 | +323,263 | 1.25 | 1.87 | +0.61 | buy |
| Paradigm Biocapital Advisors LP | 1,805,717 | 2,025,480 | +219,763 | 10.09 | 9.28 | -0.81 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,654,705 | 1,867,032 | +212,327 | 0.04 | 0.04 | +0.01 | buy |
| Avidity Partners Management LP | 798,900 | 967,000 | +168,100 | 1.93 | 2.62 | +0.69 | buy |
| TD ASSET MANAGEMENT INC | 135,706 | 271,560 | +135,854 | 0.01 | 0.02 | +0.01 | buy |
| SAMLYN CAPITAL, LLC | 281,101 | 407,546 | +126,445 | 0.34 | 0.48 | +0.15 | buy |
| BAMCO INC /NY/ | 65,700 | 157,200 | +91,500 | 0.01 | 0.03 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 116,223 | 197,219 | +80,996 | 0.02 | 0.04 | 0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,814,337 | 1,733,778 | +80,559 | 0.08 | 0.08 | 0.00 | sell |
| Erste Asset Management GmbH | 9,700 | 34,700 | +25,000 | 0.01 | 0.04 | +0.03 | buy |
| Bridgewater Associates, LP | 337,485 | 352,091 | +14,606 | 0.14 | 0.14 | -0.00 | buy |
| Andra AP-fonden | 37,800 | 51,800 | +14,000 | 0.07 | 0.21 | +0.14 | buy |
| Parkwood LLC | 4,479 | 13,567 | +9,088 | 0.06 | 0.16 | +0.11 | buy |
| HighVista Strategies LLC | 36,385 | 44,305 | +7,920 | 1.15 | 1.38 | +0.23 | buy |
| Capital International Sarl | 76,129 | 83,201 | +7,072 | 0.24 | 0.26 | +0.02 | buy |
| Korea Investment CORP | 42,190 | 47,890 | +5,700 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 4,822 | 10,322 | +5,500 | 0.03 | 0.06 | +0.04 | buy |
| TimesSquare Capital Management, LLC | 918,992 | 923,771 | +4,779 | 0.91 | 0.97 | +0.06 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 12,000 | 16,000 | +4,000 | 0.10 | 0.11 | +0.01 | buy |
| Bellevue Group AG | 275,754 | 278,154 | +2,400 | 0.27 | 0.30 | +0.03 | buy |
| Swiss National Bank | 138,194 | 139,594 | +1,400 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 849 | 2,048 | +1,199 | 0.02 | 0.04 | +0.02 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 51,679 | 52,759 | +1,080 | 2.66 | 2.23 | -0.43 | buy |
| E Fund Management Co., Ltd. | 51,679 | 52,759 | +1,080 | 0.28 | 0.27 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 84,092 | 83,097 | +995 | 0.01 | 0.01 | -0.00 | sell |
| CI INVESTMENTS INC. | 4,824 | 4,190 | +634 | 0.00 | 0.00 | 0.00 | sell |
| PRUDENTIAL PLC | 8,363 | 8,907 | +544 | 0.01 | 0.01 | -0.00 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 23,100 | 23,600 | +500 | 0.01 | 0.02 | +0.00 | buy |
| Mach-1 Financial Group, LLC | 6,702 | 7,022 | +320 | 0.19 | 0.20 | +0.01 | buy |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 1,123,692 | 1,123,828 | +136 | 9.09 | 9.13 | +0.04 | buy |
| Bell Investment Advisors, Inc | 128 | 119 | +9 | 0.00 | 0.00 | 0.00 | sell |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 144 | 135 | -9 | 0.02 | 0.01 | -0.00 | sell |
| Krane Funds Advisors LLC | 20,054 | 19,989 | -65 | 0.07 | 0.06 | -0.02 | sell |
| Capital World Investors | 2,387,975 | 2,387,832 | -143 | 0.03 | 0.03 | +0.00 | sell |
| Nicholas Investment Partners, LP | 593,167 | 593,010 | -157 | 2.80 | 2.97 | +0.17 | sell |
| VIRTUS ADVISERS, LLC | 4,982 | 4,409 | -573 | 0.20 | 0.18 | -0.02 | sell |
| EFG Asset Management (Americas) Corp. | 6,834 | 6,189 | -645 | 0.11 | 0.10 | -0.01 | sell |
| Asset Management One Co., Ltd. | 9,396 | 8,529 | -867 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 7,868 | 6,988 | -880 | 0.11 | 0.10 | -0.01 | sell |
| NATIXIS | 3,121 | 2,128 | -993 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 8,000 | 6,670 | -1,330 | 0.09 | 0.09 | -0.00 | sell |
| E. Ohman J:or Asset Management AB | 10,000 | 8,300 | -1,700 | 0.02 | 0.02 | -0.00 | sell |
| Alpha DNA Investment Management LLC | 9,844 | 7,933 | -1,911 | 0.39 | 0.34 | -0.04 | sell |
| Aberdeen Group plc | 15,603 | 13,260 | -2,343 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 278,524 | 276,051 | -2,473 | 0.01 | 0.01 | +0.00 | sell |
| Artisan Partners Limited Partnership | 563,944 | 561,272 | -2,672 | 0.06 | 0.06 | +0.00 | sell |
| National Pension Service | 21,287 | 18,130 | -3,157 | 0.00 | 0.00 | -0.00 | sell |
| ADVISORY RESEARCH INC | 9,579 | 5,131 | -4,448 | 0.08 | 0.05 | -0.04 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 13,336 | 4,765 | -8,571 | 0.14 | 0.06 | -0.08 | sell |
| EFG Asset Management (North America) Corp. | 81,113 | 72,072 | -9,041 | 1.20 | 1.15 | -0.05 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 466,590 | 457,490 | -9,100 | 0.05 | 0.04 | -0.00 | sell |
| Capital International, Inc./CA/ | 488,757 | 461,036 | -27,721 | 0.61 | 0.59 | -0.02 | sell |
| Capital International Investors | 1,862,009 | 1,832,803 | -29,206 | 0.03 | 0.03 | +0.00 | sell |
| Woodline Partners LP | 169,305 | 100,000 | -69,305 | 0.14 | 0.08 | -0.06 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 160,000 | 85,000 | -75,000 | 2.49 | 1.55 | -0.95 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 178,300 | 78,500 | -99,800 | 0.06 | 0.02 | -0.03 | sell |
| LORD, ABBETT & CO. LLC | 563,709 | 60,911 | -502,798 | 0.13 | 0.02 | -0.12 | sell |