| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 25,670,311 | 27,702,842 | +2,032,531 | 0.05 | 0.05 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 6,472,547 | 6,094,486 | -378,061 | 0.96 | 0.83 | -0.13 | sell |
| HHLR ADVISORS, LTD. | 5,984,550 | 5,984,550 | 0 | 6.84 | 4.77 | -2.07 | hold |
| BlackRock, Inc. | 4,248,568 | 4,494,623 | +246,055 | 0.00 | 0.00 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,774,009 | 3,818,009 | +44,000 | 5.05 | 3.77 | -1.27 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,962,338 | 2,962,338 | 0 | 1.91 | 1.48 | -0.43 | hold |
| Artisan Partners Limited Partnership | 2,122,268 | 2,547,952 | +425,684 | 0.11 | 0.12 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,092,732 | 2,125,085 | +32,353 | 0.04 | 0.03 | -0.00 | buy |
| BRAIDWELL LP | 2,542,104 | 1,826,155 | -715,949 | 3.09 | 1.77 | -1.32 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,560,596 | 1,632,967 | +72,371 | 0.02 | 0.02 | -0.00 | buy |
| STATE STREET CORP | 1,119,691 | 1,157,122 | +37,431 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 1,063,724 | 1,065,303 | +1,579 | 0.07 | 0.06 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 941,916 | 1,055,486 | +113,570 | 0.01 | 0.00 | -0.00 | buy |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 1,293,052 | 1,028,447 | -264,605 | 10.56 | 7.81 | -2.75 | sell |
| UBS Group AG | 1,021,556 | 1,010,859 | -10,697 | 0.01 | 0.01 | -0.00 | sell |
| Capital International Investors | 1,082,473 | 941,600 | -140,873 | 0.01 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 983,510 | 938,678 | -44,832 | 0.63 | 0.57 | -0.06 | sell |
| IvyRock Asset Management (HK) Ltd | 869,900 | 856,900 | -13,000 | 14.25 | 12.01 | -2.24 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 656,300 | 843,200 | +186,900 | 0.03 | 0.04 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 830,000 | 830,000 | 0 | 1.49 | 1.04 | -0.45 | hold |
| JOHNSON & JOHNSON | 814,586 | 814,586 | 0 | 8.44 | 5.27 | -3.17 | hold |
| MILLENNIUM MANAGEMENT LLC | 740,847 | 792,485 | +51,638 | 0.02 | 0.02 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 716,100 | 723,700 | +7,600 | 0.05 | 0.05 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 628,185 | 542,322 | -85,863 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 473,742 | 540,042 | +66,300 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 476,247 | 527,614 | +51,367 | 0.01 | 0.01 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 445,529 | 521,811 | +76,282 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 518,289 | 431,076 | -87,213 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 100,203 | 403,211 | +303,008 | 0.05 | 0.20 | +0.15 | buy |
| CITADEL ADVISORS LLC | 165,061 | 382,812 | +217,751 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 255,986 | 361,559 | +105,573 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 269,701 | 359,935 | +90,234 | 0.02 | 0.02 | +0.00 | buy |
| Empire Life Investments Inc. | 277,927 | 325,008 | +47,081 | 0.63 | 0.62 | -0.01 | buy |
| Evergreen Quality Fund GP, Ltd. | 218,700 | 314,500 | +95,800 | 0.24 | 0.23 | -0.01 | buy |
| JPMORGAN CHASE & CO | 304,321 | 309,604 | +5,283 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 255,381 | 287,101 | +31,720 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 286,500 | 286,319 | -181 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 287,039 | 280,791 | -6,248 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 261,815 | 261,815 | 0 | 0.05 | 0.04 | -0.01 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 195,060 | 243,582 | +48,522 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 246,146 | 227,508 | -18,638 | 0.01 | 0.01 | -0.00 | sell |
| Hudson Bay Capital Management LP | 154,500 | 220,000 | +65,500 | 0.04 | 0.04 | +0.01 | buy |
| Squarepoint Ops LLC | 148,681 | 215,227 | +66,546 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 205,077 | 205,077 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 162,609 | 166,194 | +3,585 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 145,694 | 166,194 | +20,500 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 118,774 | 163,148 | +44,374 | 0.01 | 0.01 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 162,055 | 162,420 | +365 | 0.90 | 0.74 | -0.16 | buy |
| Triata Capital Ltd | 107,500 | 161,800 | +54,300 | 0.74 | 0.62 | -0.13 | buy |
| iA Global Asset Management Inc. | 140,418 | 153,772 | +13,354 | 0.07 | 0.07 | -0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 94,124 | 145,647 | +51,523 | 0.01 | 0.01 | +0.00 | buy |
| CenterBook Partners LP | 105,668 | 145,531 | +39,863 | 0.21 | 0.23 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 123,977 | 143,757 | +19,780 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 122,032 | 137,597 | +15,565 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 190,017 | 128,063 | -61,954 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 122,007 | 121,823 | -184 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 350,000 | 113,460 | -236,540 | 8.08 | 1.54 | -6.53 | sell |
| Pictet Asset Management Holding SA | 98,397 | 111,447 | +13,050 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 96,768 | +96,768 | 0.00 | 0.06 | +0.06 | buy |
| Nuveen, LLC | 115,986 | 95,886 | -20,100 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 85,438 | 84,976 | -462 | 0.07 | 0.06 | -0.01 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 82,516 | +82,516 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 191,731 | 81,072 | -110,659 | 0.00 | 0.00 | -0.00 | sell |
| Raiffeisen Bank International AG | 80,000 | 75,000 | -5,000 | 0.04 | 0.03 | -0.01 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 74,751 | 74,766 | +15 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 68,607 | 68,178 | -429 | 0.00 | 0.00 | -0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 60,713 | 63,191 | +2,478 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL LONDON ASSET MANAGEMENT LTD | 60,800 | 61,600 | +800 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 61,636 | 60,178 | -1,458 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 43,992 | 57,823 | +13,831 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 35,321 | 56,817 | +21,496 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 56,688 | 54,543 | -2,145 | 0.02 | 0.01 | -0.01 | sell |
| TEMA ETFS LLC | 56,688 | 54,543 | -2,145 | 0.53 | 0.15 | -0.39 | sell |
| AVIVA PLC | 46,190 | 54,252 | +8,062 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 51,195 | 53,901 | +2,706 | 0.01 | 0.01 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 49,505 | 52,672 | +3,167 | 0.01 | 0.01 | -0.00 | buy |
| Walleye Capital LLC | 1,178 | 48,426 | +47,248 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 42,346 | 47,476 | +5,130 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 47,278 | +47,278 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 43,308 | 45,307 | +1,999 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 60,000 | 45,000 | -15,000 | 0.03 | 0.02 | -0.01 | sell |
| Engineers Gate Manager LP | 10,721 | 41,903 | +31,182 | 0.00 | 0.02 | +0.01 | buy |
| FIL Ltd | 0 | 41,777 | +41,777 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 2,190 | 41,744 | +39,554 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 45,771 | 41,051 | -4,720 | 0.04 | 0.03 | -0.01 | sell |
| GROUP ONE TRADING LLC | 12,527 | 38,708 | +26,181 | 0.01 | 0.04 | +0.02 | buy |
| Atom Investors LP | 12,696 | 38,627 | +25,931 | 0.04 | 0.10 | +0.06 | buy |
| Krane Funds Advisors LLC | 34,161 | 38,491 | +4,330 | 0.05 | 0.03 | -0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 32,587 | 35,458 | +2,871 | 0.01 | 0.01 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 947,633 | 35,167 | -912,466 | 0.08 | 0.00 | -0.07 | sell |
| STIFEL FINANCIAL CORP | 33,475 | 35,019 | +1,544 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 75,347 | 34,242 | -41,105 | 0.04 | 0.02 | -0.02 | sell |
| Man Group plc | 15,200 | 33,804 | +18,604 | 0.00 | 0.00 | +0.00 | buy |
| ABS Direct Equity Fund LLC | 33,100 | 33,100 | 0 | 1.87 | 1.54 | -0.32 | hold |
| PRUDENTIAL PLC | 36,959 | 32,962 | -3,997 | 0.01 | 0.01 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 24,942 | 32,142 | +7,200 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 50,963 | 30,963 | -20,000 | 0.95 | 0.53 | -0.42 | sell |
| E Fund Management (Hong Kong) Co., Ltd. | 26,132 | 29,922 | +3,790 | 0.89 | 0.59 | -0.30 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 25,000 | 28,600 | +3,600 | 0.01 | 0.01 | +0.00 | buy |
| Main Management ETF Advisors, LLC | 0 | 26,350 | +26,350 | 0.00 | 0.03 | +0.03 | buy |