| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,693,368 | 10,808,216 | +1,114,848 | 0.10 | 0.09 | -0.01 | buy |
| Holocene Advisors, LP | 1,269,264 | 1,760,697 | +491,433 | 0.37 | 0.41 | +0.04 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 78,500 | 417,100 | +338,600 | 0.02 | 0.09 | +0.06 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 408,549 | 566,023 | +157,474 | 1.20 | 1.41 | +0.22 | buy |
| TimesSquare Capital Management, LLC | 923,771 | 1,065,889 | +142,118 | 0.97 | 0.94 | -0.02 | buy |
| JANUS HENDERSON GROUP PLC | 1,733,778 | 1,865,157 | +131,379 | 0.08 | 0.07 | 0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,867,032 | 1,984,826 | +117,794 | 0.04 | 0.04 | -0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,668,150 | 1,776,247 | +108,097 | 0.76 | 0.62 | -0.14 | buy |
| Rock Springs Capital Management LP | 458,265 | 492,444 | +34,179 | 0.82 | 0.73 | -0.10 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 83,097 | 116,909 | +33,812 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 276,051 | 306,666 | +30,615 | 0.01 | 0.01 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 206,103 | 234,206 | +28,103 | 0.18 | 0.17 | -0.01 | buy |
| Senator Investment Group LP | 90,000 | 115,000 | +25,000 | 0.34 | 0.30 | -0.04 | buy |
| BAMCO INC /NY/ | 157,200 | 179,568 | +22,368 | 0.03 | 0.03 | -0.00 | buy |
| LMR Partners LLP | 72,200 | 86,700 | +14,500 | 0.11 | 0.13 | +0.02 | buy |
| Swiss National Bank | 139,594 | 153,994 | +14,400 | 0.01 | 0.01 | -0.00 | buy |
| Andra AP-fonden | 51,800 | 63,600 | +11,800 | 0.21 | 0.20 | -0.00 | buy |
| E Fund Management Co., Ltd. | 52,759 | 63,897 | +11,138 | 0.27 | 0.24 | -0.03 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 52,759 | 63,897 | +11,138 | 2.23 | 2.06 | -0.17 | buy |
| Candriam S.C.A. | 231,032 | 241,032 | +10,000 | 0.11 | 0.10 | -0.01 | buy |
| AVIVA PLC | 35,900 | 44,000 | +8,100 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,048 | 9,222 | +7,174 | 0.04 | 0.11 | +0.07 | buy |
| PRUDENTIAL PLC | 8,907 | 14,856 | +5,949 | 0.01 | 0.01 | +0.00 | buy |
| BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp | 23,600 | 28,800 | +5,200 | 0.02 | 0.01 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 7,700 | 10,900 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| Korea Investment CORP | 47,890 | 50,890 | +3,000 | 0.01 | 0.01 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,322 | 13,009 | +2,687 | 0.06 | 0.07 | +0.01 | buy |
| Aberdeen Group plc | 13,260 | 15,701 | +2,441 | 0.00 | 0.00 | -0.00 | buy |
| OVERSEA-CHINESE BANKING Corp Ltd | 7,240 | 9,309 | +2,069 | 0.02 | 0.02 | -0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 16,710 | 18,588 | +1,878 | 0.03 | 0.02 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,409 | 5,314 | +905 | 0.18 | 0.20 | +0.02 | buy |
| Vident Advisory, LLC | 12,270 | 11,736 | +534 | 0.03 | 0.02 | 0.00 | sell |
| Asset Management One Co., Ltd. | 8,529 | 9,055 | +526 | 0.00 | 0.00 | -0.00 | buy |
| CI INVESTMENTS INC. | 4,190 | 3,700 | +490 | 0.00 | 0.00 | 0.00 | sell |
| Krane Funds Advisors LLC | 19,989 | 20,440 | +451 | 0.06 | 0.05 | -0.00 | buy |
| NATIXIS | 2,128 | 2,022 | +106 | 0.00 | 0.00 | 0.00 | sell |
| Bell Investment Advisors, Inc | 119 | 120 | +1 | 0.00 | 0.00 | 0.00 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 135 | 36 | -99 | 0.01 | 0.00 | -0.01 | sell |
| Capital International Sarl | 83,201 | 83,001 | -200 | 0.26 | 0.19 | -0.07 | sell |
| Parkwood LLC | 13,567 | 12,884 | -683 | 0.10 | 0.09 | -0.01 | sell |
| Chicago Partners Investment Group LLC | 4,935 | 4,217 | -718 | 0.02 | 0.01 | -0.01 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 6,988 | 6,040 | -948 | 0.10 | 0.07 | -0.03 | sell |
| EFG Asset Management (Americas) Corp. | 6,189 | 4,641 | -1,548 | 0.10 | 0.06 | -0.04 | sell |
| E. Ohman J:or Asset Management AB | 8,300 | 6,600 | -1,700 | 0.02 | 0.01 | -0.01 | sell |
| Capital World Investors | 2,387,832 | 2,385,960 | -1,872 | 0.03 | 0.03 | -0.01 | sell |
| Old Well Partners, LLC | 45,200 | 42,001 | -3,199 | 2.63 | 2.35 | -0.28 | sell |
| SECTORAL ASSET MANAGEMENT INC | 6,670 | 3,000 | -3,670 | 0.09 | 0.08 | -0.01 | sell |
| WEXFORD CAPITAL LP | 14,123 | 7,062 | -7,061 | 0.21 | 0.09 | -0.12 | sell |
| Capital International Investors | 1,832,803 | 1,824,687 | -8,116 | 0.03 | 0.02 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 1,074,271 | 1,064,542 | -9,729 | 0.88 | 0.71 | -0.17 | sell |
| EFG Asset Management (North America) Corp. | 72,072 | 60,258 | -11,814 | 1.15 | 0.69 | -0.46 | sell |
| Bridgewater Associates, LP | 352,091 | 330,091 | -22,000 | 0.14 | 0.11 | -0.03 | sell |
| Capital International, Inc./CA/ | 461,036 | 432,216 | -28,820 | 0.59 | 0.41 | -0.19 | sell |
| TD ASSET MANAGEMENT INC | 271,560 | 238,216 | -33,344 | 0.02 | 0.01 | -0.01 | sell |
| Artisan Partners Limited Partnership | 561,272 | 517,837 | -43,435 | 0.06 | 0.05 | -0.02 | sell |
| LORD, ABBETT & CO. LLC | 60,911 | 3,385 | -57,526 | 0.02 | 0.00 | -0.01 | sell |
| Iron Triangle Partners LP | 452,629 | 380,000 | -72,629 | 4.44 | 2.96 | -1.49 | sell |
| Bellevue Group AG | 278,154 | 201,754 | -76,400 | 0.30 | 0.19 | -0.12 | sell |
| Paradigm Biocapital Advisors LP | 2,025,480 | 1,894,644 | -130,836 | 9.28 | 5.34 | -3.94 | sell |
| Avidity Partners Management LP | 967,000 | 685,000 | -282,000 | 2.62 | 1.50 | -1.11 | sell |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 1,123,828 | 809,574 | -314,254 | 9.13 | 6.84 | -2.29 | sell |
| BRAIDWELL LP | 879,564 | 562,600 | -316,964 | 1.87 | 1.24 | -0.62 | sell |
| HHLR ADVISORS, LTD. | 6,436,533 | 5,984,550 | -451,983 | 9.65 | 7.26 | -2.40 | sell |
| Polar Capital Holdings Plc | 1,872,118 | 1,370,476 | -501,642 | 0.93 | 0.51 | -0.42 | sell |
| Nicholas Investment Partners, LP | 593,010 | 26,650 | -566,360 | 2.97 | 0.19 | -2.79 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,708,510 | 615,000 | -1,093,510 | 0.26 | 0.08 | -0.18 | sell |