| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 3,496,234 | +3,496,234 | 0.00 | 4.21 | +4.21 | buy |
| GOLDMAN SACHS GROUP INC | 456,944 | 2,492,671 | +2,035,727 | 0.00 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,316,554 | 2,904,857 | +1,588,303 | 0.07 | 0.09 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,551,718 | +1,551,718 | 0.00 | 0.96 | +0.96 | buy |
| BRAIDWELL LP | 1,541,551 | 2,977,951 | +1,436,400 | 2.13 | 2.87 | +0.74 | buy |
| Invesco Ltd. | 2,287,606 | 3,309,971 | +1,022,365 | 0.02 | 0.02 | -0.00 | buy |
| Artisan Partners Limited Partnership | 589,671 | 1,505,562 | +915,891 | 0.04 | 0.08 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 18,100 | 908,100 | +890,000 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 118,118 | 980,038 | +861,920 | 0.00 | 0.01 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,038,505 | 5,713,696 | +675,191 | 1.11 | 0.81 | -0.30 | buy |
| JPMORGAN CHASE & CO | 363,026 | 998,016 | +634,990 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 60,500 | 642,452 | +581,952 | 0.01 | 0.05 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 243,240 | 710,626 | +467,386 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 450,000 | +450,000 | 0.00 | 0.97 | +0.97 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 681,174 | 1,099,525 | +418,351 | 0.09 | 0.08 | -0.00 | buy |
| Vestal Point Capital, LP | 125,000 | 475,000 | +350,000 | 0.48 | 0.92 | +0.44 | buy |
| TWO SIGMA ADVISERS, LP | 32,600 | 327,400 | +294,800 | 0.00 | 0.02 | +0.02 | buy |
| IvyRock Asset Management (HK) Ltd | 6,800 | 267,100 | +260,300 | 0.15 | 3.86 | +3.72 | buy |
| Alyeska Investment Group, L.P. | 0 | 250,000 | +250,000 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 243,989 | +243,989 | 0.00 | 0.01 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 953,565 | 1,177,540 | +223,975 | 0.60 | 0.52 | -0.08 | buy |
| Hudson Bay Capital Management LP | 0 | 202,500 | +202,500 | 0.00 | 0.04 | +0.04 | buy |
| NORTHERN TRUST CORP | 83,892 | 284,678 | +200,786 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 172,440 | +172,440 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,311,733 | 1,476,151 | +164,418 | 0.02 | 0.02 | -0.01 | buy |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 1,031,851 | 1,185,516 | +153,665 | 8.28 | 7.89 | -0.40 | buy |
| Jump Financial, LLC | 6,800 | 150,182 | +143,382 | 0.01 | 0.10 | +0.10 | buy |
| MORGAN STANLEY | 415,500 | 532,957 | +117,457 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 4,495,079 | 4,608,452 | +113,373 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,036,370 | 2,120,775 | +84,405 | 0.02 | 0.01 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 111,317 | 194,508 | +83,191 | 0.01 | 0.01 | +0.00 | buy |
| Alberta Investment Management Corp | 55,596 | 135,259 | +79,663 | 0.02 | 0.03 | +0.01 | buy |
| JANE STREET GROUP, LLC | 9,661 | 87,979 | +78,318 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 2,993 | 80,440 | +77,447 | 0.00 | 0.02 | +0.02 | buy |
| iA Global Asset Management Inc. | 0 | 76,380 | +76,380 | 0.00 | 0.04 | +0.04 | buy |
| Exane Asset Management | 0 | 67,782 | +67,782 | 0.00 | 1.30 | +1.30 | buy |
| Engineers Gate Manager LP | 11,754 | 66,616 | +54,862 | 0.01 | 0.04 | +0.03 | buy |
| Tiger Pacific Capital LP | 168,900 | 222,000 | +53,100 | 1.68 | 1.93 | +0.25 | buy |
| AMERIPRISE FINANCIAL INC | 713,501 | 766,440 | +52,939 | 0.01 | 0.01 | -0.00 | buy |
| Taikang Asset Management (Hong Kong) Co Ltd | 48,330 | 100,475 | +52,145 | 0.25 | 0.48 | +0.23 | buy |
| CenterBook Partners LP | 75,665 | 123,791 | +48,126 | 0.23 | 0.24 | +0.01 | buy |
| Decheng Capital LLC | 108,558 | 153,558 | +45,000 | 1.25 | 1.07 | -0.18 | buy |
| Caption Management, LLC | 0 | 42,575 | +42,575 | 0.00 | 0.06 | +0.06 | buy |
| TWINBEECH CAPITAL LP | 31,458 | 73,168 | +41,710 | 0.03 | 0.04 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,020 | 59,276 | +39,256 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 88,703 | 127,900 | +39,197 | 0.01 | 0.01 | -0.00 | buy |
| Empire Life Investments Inc. | 98,688 | 136,731 | +38,043 | 0.29 | 0.28 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 100,257 | 136,438 | +36,181 | 0.00 | 0.00 | -0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 233,208 | 266,232 | +33,024 | 0.01 | 0.01 | -0.00 | buy |
| Cinctive Capital Management LP | 0 | 30,694 | +30,694 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,431 | 83,439 | +30,008 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 365,987 | 393,452 | +27,465 | 0.10 | 0.07 | -0.03 | buy |
| Tri Locum Partners LP | 362,270 | 388,704 | +26,434 | 4.23 | 2.62 | -1.61 | buy |
| NINE MASTS CAPITAL Ltd | 13,609 | 38,466 | +24,857 | 0.31 | 0.23 | -0.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 494,864 | 519,474 | +24,610 | 0.00 | 0.00 | -0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 27,374 | 44,907 | +17,533 | 0.03 | 0.03 | -0.00 | buy |
| Creative Planning | 0 | 15,940 | +15,940 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 51,797 | 66,855 | +15,058 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 116,828 | 131,416 | +14,588 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 120,869 | 135,067 | +14,198 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 18,410 | 31,365 | +12,955 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 12,924 | +12,924 | 0.00 | 0.08 | +0.08 | buy |
| PRUDENTIAL PLC | 26,822 | 39,566 | +12,744 | 0.01 | 0.01 | -0.00 | buy |
| SG Americas Securities, LLC | 4,360 | 16,417 | +12,057 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 562 | 11,935 | +11,373 | 0.00 | 0.04 | +0.04 | buy |
| Woodline Partners LP | 109,395 | 120,304 | +10,909 | 0.05 | 0.03 | -0.02 | buy |
| Capital International, Inc./CA/ | 570,512 | 581,376 | +10,864 | 0.35 | 0.22 | -0.13 | buy |
| SIMPLEX TRADING, LLC | 0 | 10,310 | +10,310 | 0.00 | 0.01 | +0.01 | buy |
| Diversified Trust Co | 35,504 | 45,288 | +9,784 | 0.04 | 0.04 | -0.01 | buy |
| Polar Asset Management Partners Inc. | 14,859 | 24,638 | +9,779 | 0.02 | 0.01 | -0.01 | buy |
| SECTOR GAMMA AS | 38,762 | 48,495 | +9,733 | 0.57 | 0.54 | -0.03 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 60,515 | 69,594 | +9,079 | 2.64 | 1.99 | -0.65 | buy |
| FIRST TRUST ADVISORS LP | 11,721 | 20,669 | +8,948 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 3,032 | 11,532 | +8,500 | 0.01 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 7,826 | +7,826 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 7,614 | +7,614 | 0.00 | 0.10 | +0.10 | buy |
| Bayesian Capital Management, LP | 0 | 7,600 | +7,600 | 0.00 | 0.03 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 70,702 | 76,795 | +6,093 | 0.01 | 0.01 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 8,015 | 13,474 | +5,459 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 3,207 | 8,516 | +5,309 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 123,739 | 128,493 | +4,754 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 79,428 | 83,871 | +4,443 | 0.05 | 0.04 | -0.01 | buy |
| HighTower Advisors, LLC | 5,754 | 10,079 | +4,325 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 87 | 3,825 | +3,738 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 41,998 | 45,548 | +3,550 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 984 | 4,480 | +3,496 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 508,932 | 512,132 | +3,200 | 0.81 | 0.63 | -0.17 | buy |
| GUGGENHEIM CAPITAL LLC | 33,984 | 36,924 | +2,940 | 0.01 | 0.01 | -0.00 | buy |
| Walleye Trading LLC | 0 | 2,726 | +2,726 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 27,200 | 29,800 | +2,600 | 0.78 | 0.65 | -0.14 | buy |
| OFI INVEST ASSET MANAGEMENT | 0 | 2,435 | +2,435 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,542 | 9,852 | +2,310 | 0.17 | 0.13 | -0.04 | buy |
| Asset Management One Co., Ltd. | 8,788 | 11,085 | +2,297 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 87,446 | 89,669 | +2,223 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 0 | 2,082 | +2,082 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 43,140 | 45,031 | +1,891 | 0.08 | 0.05 | -0.03 | buy |
| Swiss National Bank | 165,194 | 166,994 | +1,800 | 0.01 | 0.00 | -0.00 | buy |
| AVIVA PLC | 46,600 | 48,300 | +1,700 | 0.01 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,711 | 17,320 | +1,609 | 0.08 | 0.05 | -0.03 | buy |
| SIGNATUREFD, LLC | 150 | 1,729 | +1,579 | 0.00 | 0.00 | +0.00 | buy |