| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 27,702,842 | 24,268,223 | -3,434,619 | 0.05 | 0.03 | -0.02 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,818,009 | 6,608,629 | +2,790,620 | 3.77 | 3.58 | -0.19 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 6,094,486 | 6,164,677 | +70,191 | 0.83 | 0.56 | -0.28 | buy |
| HHLR ADVISORS, LTD. | 5,984,550 | 5,984,550 | 0 | 4.77 | 4.19 | -0.58 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,962,338 | 5,932,000 | +2,969,662 | 1.48 | 1.65 | +0.17 | buy |
| BlackRock, Inc. | 4,494,623 | 4,276,913 | -217,710 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 2,784,806 | +2,784,806 | 0.00 | 0.09 | +0.09 | buy |
| Artisan Partners Limited Partnership | 2,547,952 | 2,341,074 | -206,878 | 0.12 | 0.08 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 1,055,486 | 2,174,535 | +1,119,049 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,632,967 | 1,517,067 | -115,900 | 0.02 | 0.01 | -0.01 | sell |
| STATE STREET CORP | 1,157,122 | 1,516,368 | +359,246 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 1,826,155 | 1,298,142 | -528,013 | 1.77 | 0.90 | -0.86 | sell |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 1,028,447 | 956,824 | -71,623 | 7.81 | 6.31 | -1.49 | sell |
| JPMORGAN CHASE & CO | 309,604 | 945,694 | +636,090 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Investors | 941,600 | 941,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JOHNSON & JOHNSON | 814,586 | 814,586 | 0 | 5.27 | 3.19 | -2.08 | hold |
| IvyRock Asset Management (HK) Ltd | 856,900 | 804,000 | -52,900 | 12.01 | 9.22 | -2.79 | sell |
| MARSHALL WACE, LLP | 17,872 | 755,953 | +738,081 | 0.00 | 0.02 | +0.02 | buy |
| ArrowMark Colorado Holdings LLC | 938,678 | 721,790 | -216,888 | 0.57 | 0.35 | -0.22 | sell |
| TWO SIGMA ADVISERS, LP | 723,700 | 689,600 | -34,100 | 0.05 | 0.03 | -0.02 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 582,154 | +582,154 | 0.00 | 0.02 | +0.02 | buy |
| Hudson Bay Capital Management LP | 220,000 | 575,000 | +355,000 | 0.04 | 0.07 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 540,042 | 555,436 | +15,394 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 359,935 | 526,070 | +166,135 | 0.02 | 0.02 | -0.00 | buy |
| Jump Financial, LLC | 403,211 | 523,632 | +120,421 | 0.20 | 0.14 | -0.06 | buy |
| MORGAN STANLEY | 431,076 | 482,550 | +51,474 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 521,811 | 480,143 | -41,668 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 215,227 | 409,974 | +194,747 | 0.01 | 0.02 | +0.00 | buy |
| Eagle Health Investments LP | 0 | 408,652 | +408,652 | 0.00 | 1.95 | +1.95 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 843,200 | 402,800 | -440,400 | 0.04 | 0.01 | -0.02 | sell |
| SG Americas Securities, LLC | 5,407 | 371,728 | +366,321 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 35,167 | 343,785 | +308,618 | 0.00 | 0.01 | +0.01 | buy |
| Empire Life Investments Inc. | 325,008 | 322,936 | -2,072 | 0.62 | 0.40 | -0.23 | sell |
| Walleye Capital LLC | 48,426 | 299,463 | +251,037 | 0.01 | 0.04 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 361,559 | 287,529 | -74,030 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 287,101 | 276,119 | -10,982 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 81,072 | 273,820 | +192,748 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 527,614 | 266,134 | -261,480 | 0.01 | 0.00 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 243,582 | 264,923 | +21,341 | 0.01 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 261,815 | 261,815 | 0 | 0.04 | 0.03 | -0.02 | hold |
| Triata Capital Ltd | 161,800 | 252,600 | +90,800 | 0.62 | 0.67 | +0.05 | buy |
| JANE STREET GROUP, LLC | 16,127 | 238,123 | +221,996 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 280,791 | 226,950 | -53,841 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 0 | 226,888 | +226,888 | 0.00 | 0.64 | +0.64 | buy |
| UBS Group AG | 1,010,859 | 224,612 | -786,247 | 0.01 | 0.00 | -0.01 | sell |
| Casdin Capital, LLC | 0 | 215,000 | +215,000 | 0.00 | 0.29 | +0.29 | buy |
| CenterBook Partners LP | 145,531 | 213,024 | +67,493 | 0.23 | 0.23 | -0.01 | buy |
| Woodline Partners LP | 205,077 | 205,077 | 0 | 0.03 | 0.02 | -0.01 | hold |
| CITADEL ADVISORS LLC | 382,812 | 178,040 | -204,772 | 0.01 | 0.00 | -0.01 | sell |
| Russell Investments Group, Ltd. | 1,014 | 175,832 | +174,818 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 166,194 | 166,590 | +396 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 163,148 | 163,148 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Swiss National Bank | 166,194 | 161,294 | -4,900 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 143,757 | 157,034 | +13,277 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 227,508 | 153,275 | -74,233 | 0.01 | 0.00 | -0.01 | sell |
| iA Global Asset Management Inc. | 153,772 | 153,242 | -530 | 0.07 | 0.04 | -0.03 | sell |
| VANGUARD GROUP INC | 137,597 | 149,619 | +12,022 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 139,893 | +139,893 | 0.00 | 0.01 | +0.01 | buy |
| Evergreen Quality Fund GP, Ltd. | 314,500 | 122,100 | -192,400 | 0.23 | 0.05 | -0.18 | sell |
| Pictet Asset Management Holding SA | 111,447 | 111,465 | +18 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 41,903 | 106,140 | +64,237 | 0.02 | 0.03 | +0.01 | buy |
| Bank of New York Mellon Corp | 121,823 | 103,375 | -18,448 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 57,823 | 103,022 | +45,199 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 75,000 | 100,000 | +25,000 | 0.03 | 0.03 | -0.00 | buy |
| Nuveen, LLC | 95,886 | 94,586 | -1,300 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 54,543 | 92,017 | +37,474 | 0.01 | 0.01 | -0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 91,725 | +91,725 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 60,178 | 84,981 | +24,803 | 0.00 | 0.00 | -0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 82,516 | 80,363 | -2,153 | 0.03 | 0.02 | -0.01 | sell |
| ROYAL LONDON ASSET MANAGEMENT LTD | 61,600 | 79,400 | +17,800 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 792,485 | 77,194 | -715,291 | 0.02 | 0.00 | -0.02 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 74,766 | 75,078 | +312 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 542,322 | 75,062 | -467,260 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 47,476 | 74,997 | +27,521 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 63,191 | 73,561 | +10,370 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 73,328 | +73,328 | 0.00 | 0.27 | +0.27 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 70,598 | +70,598 | 0.00 | 0.07 | +0.07 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 128,063 | 66,955 | -61,108 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 65,826 | +65,826 | 0.00 | 0.04 | +0.04 | buy |
| Bellevue Group AG | 84,976 | 63,971 | -21,005 | 0.06 | 0.03 | -0.03 | sell |
| Man Group plc | 33,804 | 61,704 | +27,900 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 54,274 | +54,274 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 52,672 | 53,300 | +628 | 0.01 | 0.01 | -0.00 | buy |
| Polar Capital Holdings Plc | 53,901 | 52,893 | -1,008 | 0.01 | 0.01 | -0.00 | sell |
| AVIVA PLC | 54,252 | 52,744 | -1,508 | 0.00 | 0.00 | -0.00 | sell |
| ABS Direct Equity Fund LLC | 33,100 | 47,200 | +14,100 | 1.54 | 1.22 | -0.32 | buy |
| Qube Research & Technologies Ltd | 0 | 44,369 | +44,369 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 35,458 | 44,107 | +8,649 | 0.01 | 0.01 | -0.00 | buy |
| Handelsbanken Fonder AB | 24,900 | 42,000 | +17,100 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 38,708 | 39,976 | +1,268 | 0.04 | 0.03 | -0.01 | buy |
| Advisors Preferred, LLC | 0 | 37,584 | +37,584 | 0.00 | 0.13 | +0.13 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 32,142 | 35,841 | +3,699 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 45,000 | 35,000 | -10,000 | 0.02 | 0.01 | -0.01 | sell |
| Headlands Technologies LLC | 0 | 34,742 | +34,742 | 0.00 | 0.06 | +0.06 | buy |
| Sterling Capital Management LLC | 34,242 | 34,275 | +33 | 0.02 | 0.01 | -0.00 | buy |
| Rock Springs Capital Management LP | 0 | 33,800 | +33,800 | 0.00 | 0.04 | +0.04 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 26,300 | 30,778 | +4,478 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 11,722 | 30,617 | +18,895 | 0.11 | 0.18 | +0.07 | buy |
| NOMURA HOLDINGS INC | 0 | 30,429 | +30,429 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 24,145 | 30,141 | +5,996 | 0.06 | 0.05 | -0.01 | buy |