| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 0 | 4,500,000 | +4,500,000 | 0.00 | 1.87 | +1.87 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 626,361 | 3,975,605 | +3,349,244 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 19,318 | 2,770,701 | +2,751,383 | 0.00 | 0.02 | +0.02 | buy |
| BlackRock, Inc. | 18,365,608 | 20,691,927 | +2,326,319 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 2,250,000 | +2,250,000 | 0.00 | 0.09 | +0.09 | buy |
| NORGES BANK | 0 | 2,233,600 | +2,233,600 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 2,200,695 | +2,200,695 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 21,700,000 | 23,888,888 | +2,188,888 | 0.96 | 1.46 | +0.51 | buy |
| ORBIMED ADVISORS LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.26 | +0.26 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 1,500,000 | +1,500,000 | 0.00 | 2.36 | +2.36 | buy |
| Vestal Point Capital, LP | 18,000,000 | 19,415,000 | +1,415,000 | 2.25 | 3.09 | +0.84 | buy |
| Aberdeen Group plc | 1,021,063 | 2,327,152 | +1,306,089 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 411,135 | 1,535,287 | +1,124,152 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,531,955 | 6,560,394 | +1,028,439 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 8,829,913 | 9,846,579 | +1,016,666 | 1.09 | 1.36 | +0.27 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 2,883,301 | 3,885,501 | +1,002,200 | 0.02 | 0.04 | +0.02 | buy |
| Octagon Capital Advisors LP | 8,859,911 | 9,693,244 | +833,333 | 4.38 | 6.06 | +1.68 | buy |
| FIRST TRUST ADVISORS LP | 0 | 791,169 | +791,169 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,750,000 | +750,000 | 0.26 | 0.58 | +0.32 | buy |
| AFFINITY WEALTH MANAGEMENT LLC | 0 | 576,808 | +576,808 | 0.00 | 0.51 | +0.51 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 553,000 | +553,000 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 522,619 | +522,619 | 0.00 | 1.26 | +1.26 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 120,200 | 640,035 | +519,835 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 510,000 | +510,000 | 0.00 | 0.01 | +0.01 | buy |
| Ghisallo Capital Management LLC | 0 | 505,000 | +505,000 | 0.00 | 0.07 | +0.07 | buy |
| Burkehill Global Management, LP | 0 | 500,000 | +500,000 | 0.00 | 0.12 | +0.12 | buy |
| Granahan Investment Management, LLC | 883,241 | 1,305,177 | +421,936 | 0.19 | 0.32 | +0.13 | buy |
| NORTHERN TRUST CORP | 1,814,318 | 2,226,210 | +411,892 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 182,164 | 590,387 | +408,223 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,808,599 | 2,200,695 | +392,096 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 379,577 | +379,577 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 22,369,645 | 22,713,118 | +343,473 | 0.01 | 0.02 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 259,605 | +259,605 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 250,000 | +250,000 | 0.00 | 0.24 | +0.24 | buy |
| CITIGROUP INC | 57,080 | 306,907 | +249,827 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 228,355 | +228,355 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 11,209,078 | 11,421,920 | +212,842 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 200,000 | +200,000 | 0.00 | 2.29 | +2.29 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 319,748 | 489,219 | +169,471 | 0.01 | 0.03 | +0.02 | buy |
| Squarepoint Ops LLC | 410,282 | 569,269 | +158,987 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 183,334 | 333,314 | +149,980 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 22,031 | 166,042 | +144,011 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 133,411 | +133,411 | 0.00 | 0.29 | +0.29 | buy |
| Hennion & Walsh Asset Management, Inc. | 391,476 | 519,120 | +127,644 | 0.06 | 0.10 | +0.04 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 439,464 | 561,808 | +122,344 | 1.40 | 2.67 | +1.27 | buy |
| Mariner, LLC | 0 | 116,582 | +116,582 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 83,019 | 189,332 | +106,313 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 104,132 | +104,132 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 268,800 | 369,000 | +100,200 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 98,346 | +98,346 | 0.00 | 0.05 | +0.05 | buy |
| XTX Topco Ltd | 10,329 | 101,195 | +90,866 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 608,123 | 697,971 | +89,848 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 72,573 | +72,573 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 517,698 | 588,427 | +70,729 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 39,856 | 108,208 | +68,352 | 0.01 | 0.03 | +0.02 | buy |
| ALPS ADVISORS INC | 222,986 | 290,543 | +67,557 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 181,769 | 243,379 | +61,610 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 2,979,429 | 3,040,466 | +61,037 | 0.80 | 0.97 | +0.17 | buy |
| OMERS ADMINISTRATION Corp | 0 | 59,100 | +59,100 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 189,240 | 247,680 | +58,440 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 170,751 | 222,347 | +51,596 | 0.03 | 0.03 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,944,671 | 1,992,229 | +47,558 | 0.48 | 0.66 | +0.18 | buy |
| Almanack Investment Partners, LLC. | 0 | 44,950 | +44,950 | 0.00 | 0.04 | +0.04 | buy |
| Russell Investments Group, Ltd. | 16,929 | 61,697 | +44,768 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 258,530 | 299,975 | +41,445 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 158,954 | 199,494 | +40,540 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 33,750 | 67,349 | +33,599 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,933 | 169,374 | +32,441 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 328,831 | 358,374 | +29,543 | 0.05 | 0.06 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 25,152 | +25,152 | 0.00 | 0.26 | +0.26 | buy |
| State of Wyoming | 0 | 24,382 | +24,382 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 120,116 | 140,846 | +20,730 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 0 | 19,447 | +19,447 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 19,144 | +19,144 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 18,553 | +18,553 | 0.00 | 0.02 | +0.02 | buy |
| KLP KAPITALFORVALTNING AS | 29,300 | 47,800 | +18,500 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 48,609 | 65,734 | +17,125 | 0.02 | 0.03 | +0.01 | buy |
| Privium Fund Management B.V. | 181,900 | 198,900 | +17,000 | 0.17 | 0.25 | +0.08 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 14,520 | +14,520 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 57,168 | 70,719 | +13,551 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 13,455 | +13,455 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 13,371 | +13,371 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 16,585 | 29,721 | +13,136 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 754,782 | 766,282 | +11,500 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 47,095 | 57,303 | +10,208 | 0.06 | 0.09 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 265,795 | 272,600 | +6,805 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 549,153 | 555,693 | +6,540 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 33,820 | 39,040 | +5,220 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 12,972 | 17,979 | +5,007 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 99,371 | 104,095 | +4,724 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 47,988 | 52,618 | +4,630 | 0.00 | 0.00 | +0.00 | buy |
| ST GERMAIN D J CO INC | 9,633 | 14,133 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 17,672 | 21,761 | +4,089 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 59,801 | 63,781 | +3,980 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 104,308 | 108,207 | +3,899 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 33,654 | 37,314 | +3,660 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 28,511 | 32,149 | +3,638 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 58,442 | 61,773 | +3,331 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 124,730 | 127,915 | +3,185 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 28,450 | 31,607 | +3,157 | 0.00 | 0.00 | +0.00 | buy |