| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 22,439,124 | 20,110,717 | -2,328,407 | 0.00 | 0.00 | +0.00 | sell |
| Avoro Capital Advisors LLC | 4,355,555 | 18,650,000 | +14,294,445 | 0.11 | 0.62 | +0.52 | buy |
| RTW INVESTMENTS, LP | 16,893,185 | 18,593,185 | +1,700,000 | 0.47 | 0.79 | +0.32 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 18,472,503 | 10,872,503 | -7,600,000 | 0.51 | 0.40 | -0.11 | sell |
| VR Adviser, LLC | 10,412,872 | 9,000,000 | -1,412,872 | 1.26 | 1.23 | -0.04 | sell |
| VANGUARD GROUP INC | 6,195,567 | 5,917,414 | -278,153 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 0 | 5,168,890 | +5,168,890 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.08 | 0.14 | +0.06 | hold |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 3,700,000 | 3,700,000 | 0 | 0.98 | 1.82 | +0.84 | hold |
| Artal Group S.A. | 3,663,104 | 3,687,548 | +24,444 | 0.22 | 0.27 | +0.05 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 3,589,333 | 3,333,333 | -256,000 | 3.58 | 6.21 | +2.64 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,380,532 | 3,135,317 | -245,215 | 0.01 | 0.01 | +0.00 | sell |
| Octagon Capital Advisors LP | 0 | 3,030,000 | +3,030,000 | 0.00 | 1.06 | +1.06 | buy |
| Polar Capital Holdings Plc | 2,518,909 | 2,518,909 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Eversept Partners, LP | 3,780,714 | 2,325,591 | -1,455,123 | 0.66 | 0.50 | -0.16 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,428,146 | 1,309,627 | -118,519 | 0.00 | 0.01 | +0.00 | sell |
| Point72 Asset Management, L.P. | 2,688,000 | 1,113,232 | -1,574,768 | 0.01 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,227,333 | 1,099,329 | -128,004 | 0.00 | 0.00 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 1,087,785 | +1,087,785 | 0.00 | 0.83 | +0.83 | buy |
| Qube Research & Technologies Ltd | 118,521 | 1,072,070 | +953,549 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 83,474 | 1,058,962 | +975,488 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 1,030,657 | +1,030,657 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 985,421 | 1,019,791 | +34,370 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 925,000 | +925,000 | 0.00 | 0.23 | +0.23 | buy |
| Palo Alto Investors LP | 529,861 | 811,268 | +281,407 | 0.08 | 0.26 | +0.18 | buy |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.36 | 0.50 | +0.14 | hold |
| Quantum Private Wealth, LLC | 639,520 | 698,520 | +59,000 | 0.47 | 0.74 | +0.27 | buy |
| Alphabet Inc. | 640,882 | 640,882 | 0 | 0.05 | 0.07 | +0.02 | hold |
| Schonfeld Strategic Advisors LLC | 1,119,375 | 552,595 | -566,780 | 0.02 | 0.01 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 414,980 | +414,980 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 143,220 | 339,520 | +196,300 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,097,400 | 328,500 | -768,900 | 0.00 | 0.00 | -0.00 | sell |
| Kovitz Investment Group Partners, LLC | 277,778 | 277,778 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CITIGROUP INC | 310,963 | 255,203 | -55,760 | 0.00 | 0.00 | +0.00 | sell |
| Marathon Trading Investment Management LLC | 0 | 223,900 | +223,900 | 0.00 | 0.25 | +0.25 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 420,000 | 220,000 | -200,000 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 63,477 | 213,946 | +150,469 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 213,721 | 211,395 | -2,326 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 0 | 189,284 | +189,284 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 188,698 | +188,698 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 181,306 | +181,306 | 0.00 | 0.14 | +0.14 | buy |
| TD ASSET MANAGEMENT INC | 175,600 | 175,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 172,769 | +172,769 | 0.00 | 0.05 | +0.05 | buy |
| Laurion Capital Management LP | 0 | 164,258 | +164,258 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 48,434 | 161,100 | +112,666 | 0.00 | 0.01 | +0.00 | buy |
| Diametric Capital, LP | 68,871 | 153,478 | +84,607 | 0.07 | 0.24 | +0.17 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 125,713 | +125,713 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 134,851 | 125,284 | -9,567 | 0.01 | 0.01 | +0.00 | sell |
| EntryPoint Capital, LLC | 291,616 | 122,905 | -168,711 | 0.49 | 0.32 | -0.18 | sell |
| TWO SIGMA INVESTMENTS, LP | 136,973 | 121,517 | -15,456 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 35,400 | 112,413 | +77,013 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 112,077 | +112,077 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 21,696 | 110,992 | +89,296 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 97,054 | +97,054 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 93,741 | +93,741 | 0.00 | 0.00 | +0.00 | buy |
| OLD MISSION CAPITAL LLC | 0 | 76,419 | +76,419 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,547 | 63,726 | +2,179 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 0 | 61,352 | +61,352 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 189,876 | 55,893 | -133,983 | 0.03 | 0.01 | -0.02 | sell |
| Jump Financial, LLC | 0 | 54,090 | +54,090 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,140 | 51,462 | +35,322 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 48,100 | +48,100 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Advisor Solutions LLC | 45,000 | 45,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Williams & Novak, LLC | 45,000 | 45,000 | 0 | 0.09 | 0.09 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 209,000 | 43,500 | -165,500 | 0.17 | 0.03 | -0.13 | sell |
| LPL Financial LLC | 58,060 | 42,062 | -15,998 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 16,285 | 41,052 | +24,767 | 0.01 | 0.02 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 21,622 | 35,908 | +14,286 | 0.01 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 32,485 | +32,485 | 0.00 | 0.00 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 29,800 | +29,800 | 0.00 | 0.05 | +0.05 | buy |
| OMERS ADMINISTRATION Corp | 0 | 28,000 | +28,000 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 27,680 | +27,680 | 0.00 | 0.02 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,769 | 27,269 | +500 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 460,066 | 26,477 | -433,589 | 0.00 | 0.00 | -0.00 | sell |
| Cannon Global Investment Management, LLC | 0 | 24,200 | +24,200 | 0.00 | 0.19 | +0.19 | buy |
| Tower Research Capital LLC (TRC) | 2,871 | 24,129 | +21,258 | 0.00 | 0.00 | +0.00 | buy |
| Lee Financial Co | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 19,050 | 19,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRW Securities, LLC | 0 | 17,800 | +17,800 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 17,638 | +17,638 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 17,290 | +17,290 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,600 | 16,918 | +1,318 | 0.00 | 0.00 | +0.00 | buy |
| StoneX Group Inc. | 0 | 14,382 | +14,382 | 0.00 | 0.00 | +0.00 | buy |
| Howard Capital Management Inc. | 14,165 | 14,165 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 11,946 | 13,103 | +1,157 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 13,000 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| TradeLink Capital LLC | 0 | 11,300 | +11,300 | 0.00 | 0.48 | +0.48 | buy |
| TWINBEECH CAPITAL LP | 0 | 10,204 | +10,204 | 0.00 | 0.00 | +0.00 | buy |
| Symmetry Investments LP | 0 | 10,100 | +10,100 | 0.00 | 0.00 | +0.00 | buy |
| Capital Investment Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quarry LP | 8,000 | 10,000 | +2,000 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 8,066 | +8,066 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 8,805 | 5,804 | -3,001 | 0.00 | 0.00 | +0.00 | sell |
| Headlands Technologies LLC | 0 | 2,315 | +2,315 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 0 | 691 | +691 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Morton Brown Family Wealth, LLC | 260 | 260 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Riggs Asset Managment Co. Inc. | 0 | 198 | +198 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 79 | 79 | 0 | 0.00 | 0.00 | 0.00 | hold |