| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 8,672,630 | 18,787,866 | +10,115,236 | 0.23 | 0.40 | +0.17 | buy |
| Point72 Asset Management, L.P. | 0 | 4,569,678 | +4,569,678 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 151,614 | 1,772,654 | +1,621,040 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 177,707 | 1,066,309 | +888,602 | 0.06 | 0.29 | +0.22 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 755,599 | +755,599 | 0.00 | 1.25 | +1.25 | buy |
| Palo Alto Investors LP | 811,268 | 1,419,468 | +608,200 | 0.22 | 0.38 | +0.16 | buy |
| BARCLAYS PLC | 335,238 | 708,966 | +373,728 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 965,556 | 1,255,556 | +290,000 | 1.02 | 1.52 | +0.50 | buy |
| Octagon Capital Advisors LP | 10,450,000 | 10,700,000 | +250,000 | 3.08 | 2.03 | -1.04 | buy |
| Jefferies Financial Group Inc. | 0 | 245,254 | +245,254 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 227,472 | +227,472 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 203,129 | +203,129 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 139,692 | +139,692 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 117,062 | +117,062 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 0 | 116,238 | +116,238 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,572,349 | 3,664,732 | +92,383 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 83,864 | +83,864 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 25,354 | 107,899 | +82,545 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 61,495 | 135,897 | +74,402 | 0.04 | 0.09 | +0.04 | buy |
| Virtus Investment Advisers, LLC | 0 | 72,957 | +72,957 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 474,257 | 547,128 | +72,871 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 87,355 | 159,899 | +72,544 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 13,531,467 | 13,589,178 | +57,711 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 20,788 | 78,335 | +57,547 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 45,200 | +45,200 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 62,990 | 107,711 | +44,721 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 585,594 | 625,198 | +39,604 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 68,035 | 99,912 | +31,877 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 16,405 | 38,897 | +22,492 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 15,528 | +15,528 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 192,079 | 205,462 | +13,383 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,071 | +13,071 | 0.00 | 0.00 | +0.00 | buy |
| SIH Partners, LLLP | 0 | 12,173 | +12,173 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 11,900 | +11,900 | 0.00 | 0.00 | +0.00 | buy |
| Camelot Portfolios, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| CWM, LLC | 0 | 10,527 | +10,527 | 0.00 | 0.00 | +0.00 | buy |
| Bordeaux Wealth Advisors LLC | 0 | 10,109 | +10,109 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 65,331 | 74,025 | +8,694 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 103,384 | 109,048 | +5,664 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 137,460 | 142,810 | +5,350 | 0.00 | 0.00 | -0.00 | buy |
| Granahan Investment Management, LLC | 1,636,381 | 1,640,793 | +4,412 | 0.12 | 0.11 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 807 | 4,230 | +3,423 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 450,261 | 453,420 | +3,159 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 20,010 | 22,700 | +2,690 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 12,990 | 15,140 | +2,150 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 59,069 | 60,069 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 4,303 | 5,248 | +945 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 814 | +814 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,011 | 63,797 | +786 | 0.00 | 0.00 | -0.00 | buy |
| XPONANCE, INC. | 11,925 | 12,639 | +714 | 0.00 | 0.00 | -0.00 | buy |
| Chicago Partners Investment Group LLC | 116,044 | 116,565 | +521 | 0.01 | 0.01 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 372 | +372 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 282 | 553 | +271 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 207 | +207 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 728 | 931 | +203 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 58,342 | 58,490 | +148 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 132 | +132 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 19,001 | 19,017 | +16 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 15,672 | 15,672 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,635 | 12,635 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 108,250 | 108,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.07 | 0.06 | -0.01 | hold |
| CIBC Private Wealth Group LLC | 6,833 | 6,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 165 | 165 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,872,503 | 10,872,503 | 0 | 0.25 | 0.25 | +0.00 | hold |
| DAFNA Capital Management LLC | 522,500 | 522,500 | 0 | 0.23 | 0.21 | -0.02 | hold |
| Lee Financial Co | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cambridge Investment Research Advisors, Inc. | 23,490 | 23,490 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 691 | 691 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 3,700,000 | 3,700,000 | 0 | 1.61 | 21.83 | +20.23 | hold |
| Allworth Financial LP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital Investment Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 79 | 79 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Avoro Capital Advisors LLC | 19,999,999 | 19,999,999 | 0 | 0.49 | 0.43 | -0.06 | hold |
| Alphabet Inc. | 640,882 | 640,882 | 0 | 0.06 | 0.06 | -0.01 | hold |
| Kovitz Investment Group Partners, LLC | 292,778 | 292,778 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 280 | 280 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Howard Capital Management Inc. | 14,165 | 14,165 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Privium Fund Management B.V. | 134,900 | 134,900 | 0 | 0.05 | 0.05 | -0.00 | hold |
| ATTICUS WEALTH MANAGEMENT, LLC | 7,425 | 7,425 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Polar Capital Holdings Plc | 3,000,000 | 3,000,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.27 | 0.25 | -0.03 | hold |
| SBI Securities Co., Ltd. | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Morton Brown Family Wealth, LLC | 260 | 260 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Marex Group plc | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Williams & Novak, LLC | 45,000 | 45,000 | 0 | 0.08 | 0.06 | -0.02 | hold |
| Police & Firemen's Retirement System of New Jersey | 45,678 | 45,678 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 28,500 | 28,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,100 | 21,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 5,534 | 5,534 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACKENZIE FINANCIAL CORP | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 20,018 | 19,958 | -60 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 380 | 290 | -90 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 130 | 0 | -130 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 130 | 0 | -130 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 20,391 | 20,257 | -134 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 22,993 | 22,844 | -149 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 154 | 0 | -154 | 0.00 | 0.00 | 0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 6,829 | 6,372 | -457 | 0.00 | 0.00 | +0.00 | sell |