| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 1,500,000 | 3,250,000 | +1,750,000 | 0.51 | 1.10 | +0.59 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,270,645 | 1,944,671 | +674,026 | 0.38 | 0.48 | +0.10 | buy |
| Palo Alto Investors LP | 1,183,195 | 1,391,382 | +208,187 | 0.91 | 0.95 | +0.05 | buy |
| Granahan Investment Management, LLC | 703,971 | 883,241 | +179,270 | 0.17 | 0.19 | +0.03 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 156,586 | 319,748 | +163,162 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 308,457 | 391,476 | +83,019 | 0.06 | 0.06 | +0.00 | buy |
| E Fund Management Co., Ltd. | 13,214 | 37,699 | +24,485 | 0.00 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 164,900 | 181,900 | +17,000 | 0.17 | 0.17 | +0.00 | buy |
| Legato Capital Management LLC | 15,023 | 21,782 | +6,759 | 0.01 | 0.01 | +0.00 | buy |
| Chung Wu Investment Group, LLC | 4,000 | 2,000 | -2,000 | 0.02 | 0.01 | -0.01 | sell |
| Allegheny Financial Group | 26,350 | 12,000 | -14,350 | 0.02 | 0.01 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 454,827 | 439,464 | -15,363 | 1.70 | 1.40 | -0.30 | sell |
| WEXFORD CAPITAL LP | 180,853 | 160,654 | -20,199 | 0.26 | 0.12 | -0.14 | sell |
| Palumbo Wealth Management LLC | 178,007 | 146,709 | -31,298 | 0.24 | 0.16 | -0.08 | sell |
| Polar Capital Holdings Plc | 7,931,403 | 5,654,340 | -2,277,063 | 0.20 | 0.11 | -0.09 | sell |
| Affinity Asset Advisors, LLC | 3,300,000 | 1,000,000 | -2,300,000 | 1.30 | 0.26 | -1.04 | sell |
| RTW INVESTMENTS, LP | 16,398,297 | 13,680,248 | -2,718,049 | 0.90 | 0.61 | -0.29 | sell |