| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 23,555,648 | 23,555,648 | 0 | 1.33 | 1.12 | -0.21 | hold |
| GOLDMAN SACHS GROUP INC | 13,692,739 | 22,369,645 | +8,676,906 | 0.01 | 0.01 | +0.00 | buy |
| Avoro Capital Advisors LLC | 21,700,000 | 21,700,000 | 0 | 1.17 | 0.96 | -0.22 | hold |
| BlackRock, Inc. | 18,643,129 | 18,365,608 | -277,521 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 13,750,000 | 18,000,000 | +4,250,000 | 2.77 | 2.25 | -0.52 | buy |
| MORGAN STANLEY | 18,078,518 | 17,965,371 | -113,147 | 0.01 | 0.00 | -0.00 | sell |
| FMR LLC | 13,528,366 | 14,321,255 | +792,889 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 16,398,297 | 13,680,248 | -2,718,049 | 0.90 | 0.61 | -0.29 | sell |
| STATE STREET CORP | 10,790,084 | 11,209,078 | +418,994 | 0.00 | 0.00 | -0.00 | buy |
| Octagon Capital Advisors LP | 8,859,911 | 8,859,911 | 0 | 6.10 | 4.38 | -1.72 | hold |
| Siren, L.L.C. | 10,129,913 | 8,829,913 | -1,300,000 | 1.66 | 1.09 | -0.57 | sell |
| Polar Capital Holdings Plc | 7,931,403 | 5,654,340 | -2,277,063 | 0.20 | 0.11 | -0.09 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 5,387,026 | 5,531,955 | +144,929 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 4,013,635 | 4,427,301 | +413,666 | 0.02 | 0.02 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.13 | 0.10 | -0.03 | hold |
| MILLENNIUM MANAGEMENT LLC | 3,178,863 | 3,281,820 | +102,957 | 0.01 | 0.01 | -0.00 | buy |
| Casdin Capital, LLC | 1,500,000 | 3,250,000 | +1,750,000 | 0.51 | 1.10 | +0.59 | buy |
| ADAR1 Capital Management, LLC | 2,495,809 | 2,979,429 | +483,620 | 1.03 | 0.80 | -0.23 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 3,722,000 | 2,883,301 | -838,699 | 0.03 | 0.02 | -0.01 | sell |
| BARCLAYS PLC | 5,539,001 | 2,812,010 | -2,726,991 | 0.01 | 0.00 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,722,165 | 2,722,165 | 0 | 0.19 | 0.14 | -0.05 | hold |
| SG Americas Securities, LLC | 781,474 | 2,176,742 | +1,395,268 | 0.01 | 0.01 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,270,645 | 1,944,671 | +674,026 | 0.38 | 0.48 | +0.10 | buy |
| NORTHERN TRUST CORP | 1,237,987 | 1,814,318 | +576,331 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,902,978 | 1,808,599 | -94,379 | 0.00 | 0.00 | -0.00 | sell |
| B Group, Inc. | 1,800,556 | 1,800,556 | 0 | 7.34 | 5.97 | -1.37 | hold |
| BANK OF AMERICA CORP /DE/ | 1,152,680 | 1,677,046 | +524,366 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 1,183,195 | 1,391,382 | +208,187 | 0.91 | 0.95 | +0.05 | buy |
| Aberdeen Group plc | 1,021,063 | 1,021,063 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 3,300,000 | 1,000,000 | -2,300,000 | 1.30 | 0.26 | -1.04 | sell |
| Granahan Investment Management, LLC | 703,971 | 883,241 | +179,270 | 0.17 | 0.19 | +0.03 | buy |
| Quantum Private Wealth, LLC | 819,715 | 849,212 | +29,497 | 1.32 | 1.17 | -0.14 | buy |
| JPMORGAN CHASE & CO | 774,412 | 754,782 | -19,630 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 351,126 | 742,081 | +390,955 | 0.00 | 0.00 | -0.00 | buy |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.77 | 0.77 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 711,235 | 626,361 | -84,874 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 624,367 | 608,123 | -16,244 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 545,286 | 549,153 | +3,867 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 383,043 | 517,698 | +134,655 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 500,000 | 513,828 | +13,828 | 0.01 | 0.01 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 218,185 | 511,983 | +293,798 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 490,472 | 490,472 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jefferies Financial Group Inc. | 25,000 | 479,000 | +454,000 | 0.00 | 0.03 | +0.02 | buy |
| Point72 Asset Management, L.P. | 3,868,682 | 461,856 | -3,406,826 | 0.03 | 0.00 | -0.03 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 454,827 | 439,464 | -15,363 | 1.70 | 1.40 | -0.30 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 171,100 | 413,203 | +242,103 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,854,855 | 411,135 | -1,443,720 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 471,577 | 410,282 | -61,295 | 0.01 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 308,457 | 391,476 | +83,019 | 0.06 | 0.06 | +0.00 | buy |
| Invesco Ltd. | 1,332,780 | 368,021 | -964,759 | 0.00 | 0.00 | -0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 328,831 | +328,831 | 0.00 | 0.05 | +0.05 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 156,586 | 319,748 | +163,162 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 344,784 | 299,903 | -44,881 | 0.01 | 0.01 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 275,111 | 275,111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 268,800 | 268,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 167,500 | 265,795 | +98,295 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 113,178 | 263,332 | +150,154 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 257,440 | 258,530 | +1,090 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 980,768 | 258,269 | -722,499 | 2.89 | 0.82 | -2.06 | sell |
| ALPS ADVISORS INC | 224,920 | 222,986 | -1,934 | 0.01 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 195,764 | 195,745 | -19 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 179,640 | 189,240 | +9,600 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 305,086 | 183,334 | -121,752 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 11,574 | 182,164 | +170,590 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 164,900 | 181,900 | +17,000 | 0.17 | 0.17 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 160,779 | 181,769 | +20,990 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 168,862 | 177,309 | +8,447 | 0.00 | 0.00 | -0.00 | buy |
| Chicago Partners Investment Group LLC | 166,541 | 170,751 | +4,210 | 0.02 | 0.03 | +0.01 | buy |
| WEXFORD CAPITAL LP | 180,853 | 160,654 | -20,199 | 0.26 | 0.12 | -0.14 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 121,814 | 158,954 | +37,140 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 178,007 | 146,709 | -31,298 | 0.24 | 0.16 | -0.08 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 143,575 | +143,575 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 138,580 | 136,933 | -1,647 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 128,590 | 134,671 | +6,081 | 0.02 | 0.02 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 122,639 | 124,730 | +2,091 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 172,482 | 120,200 | -52,282 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 113,266 | 120,116 | +6,850 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 124,975 | 116,297 | -8,678 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 108,399 | 108,399 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 133,146 | 104,308 | -28,838 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,085 | 99,371 | +32,286 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 42,070 | 83,019 | +40,949 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 67,477 | 80,779 | +13,302 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 69,000 | 69,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 67,500 | 67,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 63,235 | 59,801 | -3,434 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 55,657 | 58,442 | +2,785 | 0.00 | 0.00 | -0.00 | buy |
| Abacus Wealth Partners, LLC | 55,173 | 58,241 | +3,068 | 0.03 | 0.02 | -0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 57,168 | 57,168 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 63,015 | 57,080 | -5,935 | 0.00 | 0.00 | -0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 57,975 | 56,577 | -1,398 | 0.00 | 0.00 | -0.00 | sell |
| NBC SECURITIES, INC. | 52,955 | 54,058 | +1,103 | 0.02 | 0.02 | -0.00 | buy |
| SEI INVESTMENTS CO | 47,858 | 51,472 | +3,614 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 44,635 | 48,609 | +3,974 | 0.02 | 0.02 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 71,069 | 47,988 | -23,081 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 45,946 | 47,095 | +1,149 | 0.07 | 0.06 | -0.01 | buy |
| State of New Jersey Common Pension Fund D | 0 | 46,807 | +46,807 | 0.00 | 0.00 | +0.00 | buy |
| Williams & Novak, LLC | 45,000 | 45,000 | 0 | 0.19 | 0.15 | -0.04 | hold |
| ProShare Advisors LLC | 52,463 | 44,267 | -8,196 | 0.00 | 0.00 | -0.00 | sell |
| FIRST MANHATTAN CO. LLC. | 43,500 | 43,500 | 0 | 0.00 | 0.00 | -0.00 | hold |