| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 339,520 | 3,318,421 | +2,978,901 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 93,741 | 2,963,553 | +2,869,812 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 2,537,348 | +2,537,348 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 5,168,890 | 7,477,397 | +2,308,507 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,019,791 | 2,880,485 | +1,860,694 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 3,030,000 | 4,572,222 | +1,542,222 | 1.06 | 1.69 | +0.63 | buy |
| VANGUARD GROUP INC | 5,917,414 | 7,167,337 | +1,249,923 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 20,110,717 | 21,210,636 | +1,099,919 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 0 | 1,026,269 | +1,026,269 | 0.00 | 0.02 | +0.02 | buy |
| Granahan Investment Management, LLC | 0 | 809,691 | +809,691 | 0.00 | 0.07 | +0.07 | buy |
| Artal Group S.A. | 3,687,548 | 4,354,214 | +666,666 | 0.27 | 0.25 | -0.02 | buy |
| Polar Capital Holdings Plc | 2,518,909 | 3,025,000 | +506,091 | 0.04 | 0.04 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 454,464 | +454,464 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 397,750 | +397,750 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,462 | 429,744 | +378,282 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 153,478 | 512,361 | +358,883 | 0.24 | 0.62 | +0.38 | buy |
| Schonfeld Strategic Advisors LLC | 552,595 | 769,200 | +216,605 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 48,100 | 257,694 | +209,594 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 43,500 | 250,800 | +207,300 | 0.03 | 0.11 | +0.08 | buy |
| RTW INVESTMENTS, LP | 18,593,185 | 18,800,299 | +207,114 | 0.79 | 0.65 | -0.14 | buy |
| RHUMBLINE ADVISERS | 0 | 184,284 | +184,284 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,099,329 | 1,276,578 | +177,249 | 0.00 | 0.00 | -0.00 | buy |
| Alpine Global Management, LLC | 0 | 151,483 | +151,483 | 0.00 | 0.06 | +0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 141,805 | +141,805 | 0.00 | 0.02 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 55,893 | 186,591 | +130,698 | 0.01 | 0.04 | +0.02 | buy |
| Privium Fund Management B.V. | 0 | 98,500 | +98,500 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 95,600 | +95,600 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 69,742 | +69,742 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,726 | 133,213 | +69,487 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 64,800 | +64,800 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 211,395 | 270,766 | +59,371 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 57,191 | +57,191 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 0 | 54,234 | +54,234 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 53,934 | +53,934 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 46,854 | +46,854 | 0.00 | 0.00 | +0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 46,400 | +46,400 | 0.00 | 0.08 | +0.08 | buy |
| Scientech Research LLC | 0 | 43,350 | +43,350 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 0 | 41,794 | +41,794 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 698,520 | 730,520 | +32,000 | 0.74 | 0.58 | -0.16 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 26,634 | +26,634 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 21,709 | +21,709 | 0.00 | 0.02 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 21,609 | +21,609 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 17,925 | +17,925 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 15,672 | +15,672 | 0.00 | 0.00 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 277,778 | 292,778 | +15,000 | 0.01 | 0.01 | -0.00 | buy |
| Marex Group plc | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 11,591 | +11,591 | 0.00 | 0.00 | +0.00 | buy |
| Camelot Portfolios, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 42,062 | 48,060 | +5,998 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 5,583 | +5,583 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 5,534 | +5,534 | 0.00 | 0.00 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 1,797 | +1,797 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 16,918 | 18,062 | +1,144 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 280 | +280 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 175,600 | 175,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.14 | 0.11 | -0.03 | hold |
| Palo Alto Investors LP | 811,268 | 811,268 | 0 | 0.26 | 0.21 | -0.05 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,872,503 | 10,872,503 | 0 | 0.40 | 0.32 | -0.07 | hold |
| Lee Financial Co | 20,000 | 20,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Daiwa Securities Group Inc. | 691 | 691 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 3,700,000 | 3,700,000 | 0 | 1.82 | 1.69 | -0.13 | hold |
| Allworth Financial LP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Investment Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 79 | 79 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Dynamic Advisor Solutions LLC | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Riggs Asset Managment Co. Inc. | 198 | 198 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 9,000,000 | 9,000,000 | 0 | 1.23 | 1.28 | +0.06 | hold |
| Avoro Capital Advisors LLC | 18,650,000 | 18,650,000 | 0 | 0.62 | 0.56 | -0.07 | hold |
| Alphabet Inc. | 640,882 | 640,882 | 0 | 0.07 | 0.07 | -0.00 | hold |
| Howard Capital Management Inc. | 14,165 | 14,165 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.50 | 0.54 | +0.04 | hold |
| Morton Brown Family Wealth, LLC | 260 | 260 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Williams & Novak, LLC | 45,000 | 45,000 | 0 | 0.09 | 0.09 | +0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 27,269 | 27,269 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aquatic Capital Management LLC | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 17,290 | 16,505 | -785 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 13,103 | 11,545 | -1,558 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 17,638 | 16,077 | -1,561 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 125,713 | 123,974 | -1,739 | 0.00 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 2,315 | 0 | -2,315 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 5,804 | 366 | -5,438 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 19,050 | 11,190 | -7,860 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 8,066 | 0 | -8,066 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 125,284 | 116,905 | -8,379 | 0.01 | 0.01 | -0.00 | sell |
| Quarry LP | 10,000 | 0 | -10,000 | 0.01 | 0.00 | -0.01 | sell |
| Symmetry Investments LP | 10,100 | 0 | -10,100 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 10,204 | 0 | -10,204 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 24,129 | 13,037 | -11,092 | 0.00 | 0.00 | -0.00 | sell |
| TradeLink Capital LLC | 11,300 | 0 | -11,300 | 0.48 | 0.00 | -0.48 | sell |
| Walleye Capital LLC | 13,000 | 0 | -13,000 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 35,908 | 21,971 | -13,937 | 0.01 | 0.01 | -0.01 | sell |
| StoneX Group Inc. | 14,382 | 0 | -14,382 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 17,800 | 0 | -17,800 | 0.00 | 0.00 | -0.00 | sell |
| Cannon Global Investment Management, LLC | 24,200 | 0 | -24,200 | 0.19 | 0.00 | -0.19 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 26,477 | 0 | -26,477 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 27,680 | 0 | -27,680 | 0.02 | 0.00 | -0.02 | sell |
| OMERS ADMINISTRATION Corp | 28,000 | 0 | -28,000 | 0.00 | 0.00 | -0.00 | sell |
| CTC Alternative Strategies, Ltd. | 29,800 | 0 | -29,800 | 0.05 | 0.00 | -0.05 | sell |