| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 18,787,866 | 25,021,584 | +6,233,718 | 0.40 | 0.82 | +0.42 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,872,503 | 23,555,648 | +12,683,145 | 0.25 | 0.92 | +0.66 | buy |
| Avoro Capital Advisors LLC | 19,999,999 | 21,700,000 | +1,700,001 | 0.43 | 0.88 | +0.44 | buy |
| MORGAN STANLEY | 16,846,374 | 16,865,082 | +18,708 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 15,631,954 | 15,627,822 | -4,132 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 13,589,178 | 13,303,775 | -285,403 | 0.00 | 0.00 | +0.00 | sell |
| Octagon Capital Advisors LP | 2,425,000 | 12,592,500 | +10,167,500 | 2.43 | 6.38 | +3.96 | buy |
| GOLDMAN SACHS GROUP INC | 359,007 | 12,587,700 | +12,228,693 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 6,514,737 | 11,014,737 | +4,500,000 | 0.51 | 1.32 | +0.81 | buy |
| VANGUARD GROUP INC | 8,770,921 | 10,894,127 | +2,123,206 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 245,254 | 10,313,733 | +10,068,479 | 0.01 | 0.39 | +0.39 | buy |
| Point72 Asset Management, L.P. | 4,569,678 | 7,317,614 | +2,747,936 | 0.02 | 0.04 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 5,386,000 | +5,386,000 | 0.00 | 0.23 | +0.23 | buy |
| STATE STREET CORP | 3,233,512 | 5,138,310 | +1,904,798 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 3,000,000 | 5,000,000 | +2,000,000 | 0.03 | 0.06 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 4,839,000 | +4,839,000 | 0.00 | 0.02 | +0.02 | buy |
| TORONTO DOMINION BANK | 0 | 4,728,806 | +4,728,806 | 0.00 | 0.02 | +0.02 | buy |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 3,700,000 | 4,095,000 | +395,000 | 21.83 | 27.39 | +5.55 | buy |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.06 | 0.09 | +0.03 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 3,664,732 | 3,793,572 | +128,840 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 3,217,449 | +3,217,449 | 0.00 | 0.28 | +0.28 | buy |
| ADAR1 Capital Management, LLC | 1,066,309 | 3,009,870 | +1,943,561 | 0.29 | 1.13 | +0.84 | buy |
| Vestal Point Capital, LP | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.36 | +0.36 | buy |
| MPM BioImpact LLC | 0 | 2,953,562 | +2,953,562 | 0.00 | 1.18 | +1.18 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,772,654 | 2,935,728 | +1,163,074 | 0.00 | 0.01 | +0.00 | buy |
| B Group, Inc. | 1,255,556 | 1,800,556 | +545,000 | 1.52 | 3.59 | +2.08 | buy |
| GREAT POINT PARTNERS LLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 2.25 | +2.25 | buy |
| NORTHERN TRUST CORP | 1,431,666 | 1,328,741 | -102,925 | 0.00 | 0.00 | +0.00 | sell |
| Palo Alto Investors LP | 1,419,468 | 1,246,033 | -173,435 | 0.38 | 0.61 | +0.24 | sell |
| STEMPOINT CAPITAL LP | 0 | 1,203,941 | +1,203,941 | 0.00 | 0.90 | +0.90 | buy |
| Woodline Partners LP | 858,254 | 1,000,254 | +142,000 | 0.01 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 1,640,793 | 958,493 | -682,300 | 0.11 | 0.09 | -0.02 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 900,000 | +900,000 | 0.00 | 0.11 | +0.11 | buy |
| Quantum Private Wealth, LLC | 791,476 | 815,976 | +24,500 | 0.42 | 0.61 | +0.19 | buy |
| Anson Funds Management LP | 0 | 803,500 | +803,500 | 0.00 | 0.34 | +0.34 | buy |
| BANK OF AMERICA CORP /DE/ | 636,842 | 730,728 | +93,886 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.25 | 0.33 | +0.08 | hold |
| Alphabet Inc. | 640,882 | 640,882 | 0 | 0.06 | 0.07 | +0.01 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 625,198 | 635,968 | +10,770 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 216,611 | 528,993 | +312,382 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 495,311 | +495,311 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 493,301 | +493,301 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 547,128 | 491,709 | -55,419 | 0.00 | 0.00 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 485,669 | +485,669 | 0.00 | 1.57 | +1.57 | buy |
| Nuveen, LLC | 546,414 | 465,144 | -81,270 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 453,420 | 458,659 | +5,239 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 708,966 | 450,501 | -258,465 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 420,000 | +420,000 | 0.00 | 0.25 | +0.25 | buy |
| D. E. Shaw & Co., Inc. | 0 | 401,509 | +401,509 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 203,129 | 320,737 | +117,608 | 0.01 | 0.03 | +0.02 | buy |
| Kovitz Investment Group Partners, LLC | 292,778 | 298,667 | +5,889 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 418,132 | 261,239 | -156,893 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 205,462 | 233,256 | +27,794 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,003,067 | 222,649 | -780,418 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 227,472 | 212,572 | -14,900 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 159,899 | 203,671 | +43,772 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.07 | +0.07 | buy |
| ALLIANCEBERNSTEIN L.P. | 108,250 | 179,620 | +71,370 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 116,565 | 163,766 | +47,201 | 0.01 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 161,940 | +161,940 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 148,357 | +148,357 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 136,994 | +136,994 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 107,899 | 135,766 | +27,867 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 134,900 | 134,900 | 0 | 0.05 | 0.07 | +0.02 | hold |
| CITIGROUP INC | 133,194 | 130,317 | -2,877 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 0 | 118,683 | +118,683 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 142,810 | 117,740 | -25,070 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 116,238 | 108,399 | -7,839 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 107,711 | 108,078 | +367 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 134,418 | 107,716 | -26,702 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 109,048 | 107,234 | -1,814 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 0 | 100,226 | +100,226 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 103,074 | 96,543 | -6,531 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 74,025 | 84,603 | +10,578 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 99,912 | 82,195 | -17,717 | 0.00 | 0.00 | +0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 80,571 | +80,571 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 79,498 | +79,498 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 72,900 | +72,900 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 135,897 | 69,109 | -66,788 | 0.09 | 0.08 | -0.01 | sell |
| Militia Capital Partners, LP | 0 | 66,800 | +66,800 | 0.00 | 0.07 | +0.07 | buy |
| Engineers Gate Manager LP | 0 | 64,617 | +64,617 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,797 | 61,005 | -2,792 | 0.00 | 0.00 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 60,069 | 60,036 | -33 | 0.00 | 0.00 | +0.00 | sell |
| AXQ CAPITAL, LP | 0 | 57,000 | +57,000 | 0.00 | 0.04 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 54,900 | +54,900 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 41,120 | 52,527 | +11,407 | 0.01 | 0.01 | +0.01 | buy |
| Creative Planning | 78,335 | 51,981 | -26,354 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 48,616 | 47,169 | -1,447 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 45,678 | 45,678 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Williams & Novak, LLC | 45,000 | 45,000 | 0 | 0.06 | 0.09 | +0.03 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 44,690 | +44,690 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 47,195 | 43,746 | -3,449 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 72,957 | 35,484 | -37,473 | 0.03 | 0.03 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 32,682 | +32,682 | 0.00 | 0.00 | +0.00 | buy |
| FIRST MANHATTAN CO. LLC. | 28,500 | 28,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ethic Inc. | 0 | 27,975 | +27,975 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 26,599 | +26,599 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 19,017 | 25,492 | +6,475 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 25,252 | +25,252 | 0.00 | 0.01 | +0.01 | buy |
| Daiwa Securities Group Inc. | 691 | 23,841 | +23,150 | 0.00 | 0.00 | +0.00 | buy |