| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,872,503 | 23,555,648 | +12,683,145 | 0.25 | 0.92 | +0.66 | buy |
| GOLDMAN SACHS GROUP INC | 359,007 | 12,587,700 | +12,228,693 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 2,425,000 | 12,592,500 | +10,167,500 | 2.43 | 6.38 | +3.96 | buy |
| Jefferies Financial Group Inc. | 245,254 | 10,313,733 | +10,068,479 | 0.01 | 0.39 | +0.39 | buy |
| RTW INVESTMENTS, LP | 18,787,866 | 25,021,584 | +6,233,718 | 0.40 | 0.82 | +0.42 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 5,386,000 | +5,386,000 | 0.00 | 0.23 | +0.23 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 4,839,000 | +4,839,000 | 0.00 | 0.02 | +0.02 | buy |
| TORONTO DOMINION BANK | 0 | 4,728,806 | +4,728,806 | 0.00 | 0.02 | +0.02 | buy |
| Siren, L.L.C. | 6,514,737 | 11,014,737 | +4,500,000 | 0.51 | 1.32 | +0.81 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 3,217,449 | +3,217,449 | 0.00 | 0.28 | +0.28 | buy |
| Vestal Point Capital, LP | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.36 | +0.36 | buy |
| MPM BioImpact LLC | 0 | 2,953,562 | +2,953,562 | 0.00 | 1.18 | +1.18 | buy |
| Point72 Asset Management, L.P. | 4,569,678 | 7,317,614 | +2,747,936 | 0.02 | 0.04 | +0.02 | buy |
| VANGUARD GROUP INC | 8,770,921 | 10,894,127 | +2,123,206 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 3,000,000 | 5,000,000 | +2,000,000 | 0.03 | 0.06 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 1,066,309 | 3,009,870 | +1,943,561 | 0.29 | 1.13 | +0.84 | buy |
| STATE STREET CORP | 3,233,512 | 5,138,310 | +1,904,798 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 19,999,999 | 21,700,000 | +1,700,001 | 0.43 | 0.88 | +0.44 | buy |
| GREAT POINT PARTNERS LLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 2.25 | +2.25 | buy |
| STEMPOINT CAPITAL LP | 0 | 1,203,941 | +1,203,941 | 0.00 | 0.90 | +0.90 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,772,654 | 2,935,728 | +1,163,074 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 900,000 | +900,000 | 0.00 | 0.11 | +0.11 | buy |
| Anson Funds Management LP | 0 | 803,500 | +803,500 | 0.00 | 0.34 | +0.34 | buy |
| B Group, Inc. | 1,255,556 | 1,800,556 | +545,000 | 1.52 | 3.59 | +2.08 | buy |
| ROYAL BANK OF CANADA | 0 | 495,311 | +495,311 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 493,301 | +493,301 | 0.00 | 0.01 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 485,669 | +485,669 | 0.00 | 1.57 | +1.57 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 420,000 | +420,000 | 0.00 | 0.25 | +0.25 | buy |
| D. E. Shaw & Co., Inc. | 0 | 401,509 | +401,509 | 0.00 | 0.00 | +0.00 | buy |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 3,700,000 | 4,095,000 | +395,000 | 21.83 | 27.39 | +5.55 | buy |
| CITADEL ADVISORS LLC | 216,611 | 528,993 | +312,382 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.07 | +0.07 | buy |
| Quadrature Capital Ltd | 0 | 161,940 | +161,940 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 148,357 | +148,357 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 858,254 | 1,000,254 | +142,000 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 136,994 | +136,994 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,664,732 | 3,793,572 | +128,840 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 118,683 | +118,683 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 203,129 | 320,737 | +117,608 | 0.01 | 0.03 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 100,226 | +100,226 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 636,842 | 730,728 | +93,886 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 80,571 | +80,571 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 79,498 | +79,498 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 72,900 | +72,900 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 108,250 | 179,620 | +71,370 | 0.00 | 0.00 | +0.00 | buy |
| Militia Capital Partners, LP | 0 | 66,800 | +66,800 | 0.00 | 0.07 | +0.07 | buy |
| Engineers Gate Manager LP | 0 | 64,617 | +64,617 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 57,000 | +57,000 | 0.00 | 0.04 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 54,900 | +54,900 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 116,565 | 163,766 | +47,201 | 0.01 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 44,690 | +44,690 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 159,899 | 203,671 | +43,772 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 32,682 | +32,682 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 0 | 27,975 | +27,975 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 107,899 | 135,766 | +27,867 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 205,462 | 233,256 | +27,794 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 26,599 | +26,599 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 25,252 | +25,252 | 0.00 | 0.01 | +0.01 | buy |
| Quantum Private Wealth, LLC | 791,476 | 815,976 | +24,500 | 0.42 | 0.61 | +0.19 | buy |
| Daiwa Securities Group Inc. | 691 | 23,841 | +23,150 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 16,846,374 | 16,865,082 | +18,708 | 0.00 | 0.00 | +0.00 | buy |
| May Hill Capital, LLC | 0 | 16,051 | +16,051 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 0 | 13,214 | +13,214 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 41,120 | 52,527 | +11,407 | 0.01 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 625,198 | 635,968 | +10,770 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,864 | 17,606 | +10,742 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 74,025 | 84,603 | +10,578 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 10,063 | +10,063 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 15,140 | 22,790 | +7,650 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 19,017 | 25,492 | +6,475 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 12,241 | 18,591 | +6,350 | 0.00 | 0.00 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 292,778 | 298,667 | +5,889 | 0.00 | 0.00 | +0.00 | buy |
| ST GERMAIN D J CO INC | 0 | 5,300 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 453,420 | 458,659 | +5,239 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 6,372 | 10,103 | +3,731 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 3,263 | +3,263 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 3,037 | +3,037 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 10,527 | 12,946 | +2,419 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 814 | 2,147 | +1,333 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 805 | 2,065 | +1,260 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 10,000 | 11,214 | +1,214 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 690 | +690 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 107,711 | 108,078 | +367 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 165 | 408 | +243 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 23,490 | 23,690 | +200 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 12,639 | 12,837 | +198 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 105 | +105 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 48 | +48 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 931 | 975 | +44 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 15,672 | 15,672 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,635 | 12,635 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.06 | 0.09 | +0.03 | hold |
| Lee Financial Co | 20,000 | 20,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Capital Investment Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital Advisors, Ltd. LLC | 79 | 79 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Alphabet Inc. | 640,882 | 640,882 | 0 | 0.06 | 0.07 | +0.01 | hold |
| Parallel Advisors, LLC | 280 | 280 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Howard Capital Management Inc. | 14,165 | 14,165 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Privium Fund Management B.V. | 134,900 | 134,900 | 0 | 0.05 | 0.07 | +0.02 | hold |