| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,872,503 | 23,555,648 | +12,683,145 | 0.25 | 0.92 | +0.66 | buy |
| RTW INVESTMENTS, LP | 18,787,866 | 25,021,584 | +6,233,718 | 0.40 | 0.82 | +0.42 | buy |
| Siren, L.L.C. | 6,514,737 | 11,014,737 | +4,500,000 | 0.51 | 1.32 | +0.81 | buy |
| Polar Capital Holdings Plc | 3,000,000 | 5,000,000 | +2,000,000 | 0.03 | 0.06 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 1,066,309 | 3,009,870 | +1,943,561 | 0.29 | 1.13 | +0.84 | buy |
| Octagon Capital Advisors LP | 10,700,000 | 12,592,500 | +1,892,500 | 2.93 | 6.38 | +3.46 | buy |
| Avoro Capital Advisors LLC | 19,999,999 | 21,700,000 | +1,700,001 | 0.43 | 0.88 | +0.44 | buy |
| B Group, Inc. | 1,255,556 | 1,800,556 | +545,000 | 1.52 | 3.59 | +2.08 | buy |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 3,700,000 | 4,095,000 | +395,000 | 21.83 | 27.39 | +5.55 | buy |
| Woodline Partners LP | 858,254 | 1,000,254 | +142,000 | 0.01 | 0.01 | +0.00 | buy |
| Quantum Private Wealth, LLC | 791,476 | 815,976 | +24,500 | 0.42 | 0.61 | +0.19 | buy |
| China Universal Asset Management Co., Ltd. | 41,120 | 52,527 | +11,407 | 0.01 | 0.01 | +0.01 | buy |
| Bordeaux Wealth Advisors LLC | 10,109 | 10,058 | -51 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 72,957 | 35,484 | -37,473 | 0.03 | 0.03 | +0.00 | sell |
| EntryPoint Capital, LLC | 135,897 | 69,109 | -66,788 | 0.09 | 0.08 | -0.01 | sell |
| Palo Alto Investors LP | 1,419,468 | 1,246,033 | -173,435 | 0.38 | 0.61 | +0.24 | sell |
| Granahan Investment Management, LLC | 1,640,793 | 958,493 | -682,300 | 0.11 | 0.09 | -0.02 | sell |