| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 21,700,000 | 23,888,888 | +2,188,888 | 0.96 | 1.46 | +0.51 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 23,555,648 | 23,555,648 | 0 | 1.12 | 1.39 | +0.28 | hold |
| GOLDMAN SACHS GROUP INC | 22,369,645 | 22,713,118 | +343,473 | 0.01 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 18,365,608 | 20,691,927 | +2,326,319 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 18,000,000 | 19,415,000 | +1,415,000 | 2.25 | 3.09 | +0.84 | buy |
| MORGAN STANLEY | 17,965,371 | 16,487,479 | -1,477,892 | 0.00 | 0.01 | +0.00 | sell |
| RTW INVESTMENTS, LP | 13,680,248 | 13,560,258 | -119,990 | 0.61 | 0.79 | +0.18 | sell |
| FMR LLC | 14,321,255 | 13,336,413 | -984,842 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 11,209,078 | 11,421,920 | +212,842 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 8,829,913 | 9,846,579 | +1,016,666 | 1.09 | 1.36 | +0.27 | buy |
| Octagon Capital Advisors LP | 8,859,911 | 9,693,244 | +833,333 | 4.38 | 6.06 | +1.68 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,531,955 | 6,560,394 | +1,028,439 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 5,654,340 | 5,117,133 | -537,207 | 0.11 | 0.10 | -0.01 | sell |
| MPM BioImpact LLC | 0 | 4,500,000 | +4,500,000 | 0.00 | 1.87 | +1.87 | buy |
| D. E. Shaw & Co., Inc. | 4,427,301 | 4,398,652 | -28,649 | 0.02 | 0.02 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.10 | 0.14 | +0.03 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 626,361 | 3,975,605 | +3,349,244 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 2,883,301 | 3,885,501 | +1,002,200 | 0.02 | 0.04 | +0.02 | buy |
| Casdin Capital, LLC | 3,250,000 | 3,250,000 | 0 | 1.10 | 1.11 | +0.01 | hold |
| ADAR1 Capital Management, LLC | 2,979,429 | 3,040,466 | +61,037 | 0.80 | 0.97 | +0.17 | buy |
| Pictet Asset Management Holding SA | 19,318 | 2,770,701 | +2,751,383 | 0.00 | 0.02 | +0.02 | buy |
| Aberdeen Group plc | 1,021,063 | 2,327,152 | +1,306,089 | 0.01 | 0.02 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 2,250,000 | +2,250,000 | 0.00 | 0.09 | +0.09 | buy |
| NORGES BANK | 0 | 2,233,600 | +2,233,600 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,814,318 | 2,226,210 | +411,892 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 2,200,695 | +2,200,695 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,808,599 | 2,200,695 | +392,096 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,281,820 | 2,126,838 | -1,154,982 | 0.01 | 0.01 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.26 | +0.26 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,944,671 | 1,992,229 | +47,558 | 0.48 | 0.66 | +0.18 | buy |
| B Group, Inc. | 1,800,556 | 1,800,556 | 0 | 5.97 | 6.96 | +0.99 | hold |
| Affinity Asset Advisors, LLC | 1,000,000 | 1,750,000 | +750,000 | 0.26 | 0.58 | +0.32 | buy |
| BARCLAYS PLC | 2,812,010 | 1,630,659 | -1,181,351 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 411,135 | 1,535,287 | +1,124,152 | 0.00 | 0.01 | +0.00 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 1,500,000 | +1,500,000 | 0.00 | 2.36 | +2.36 | buy |
| Palo Alto Investors LP | 1,391,382 | 1,391,382 | 0 | 0.95 | 1.31 | +0.36 | hold |
| BANK OF AMERICA CORP /DE/ | 1,677,046 | 1,372,845 | -304,201 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 883,241 | 1,305,177 | +421,936 | 0.19 | 0.32 | +0.13 | buy |
| Quantum Private Wealth, LLC | 849,212 | 812,027 | -37,185 | 1.17 | 1.42 | +0.24 | sell |
| FIRST TRUST ADVISORS LP | 0 | 791,169 | +791,169 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 754,782 | 766,282 | +11,500 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.77 | 0.80 | +0.04 | hold |
| Bank of New York Mellon Corp | 608,123 | 697,971 | +89,848 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 120,200 | 640,035 | +519,835 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 182,164 | 590,387 | +408,223 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 517,698 | 588,427 | +70,729 | 0.00 | 0.00 | +0.00 | buy |
| AFFINITY WEALTH MANAGEMENT LLC | 0 | 576,808 | +576,808 | 0.00 | 0.51 | +0.51 | buy |
| Squarepoint Ops LLC | 410,282 | 569,269 | +158,987 | 0.00 | 0.01 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 439,464 | 561,808 | +122,344 | 1.40 | 2.67 | +1.27 | buy |
| Nuveen, LLC | 549,153 | 555,693 | +6,540 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 553,000 | +553,000 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 522,619 | +522,619 | 0.00 | 1.26 | +1.26 | buy |
| Hennion & Walsh Asset Management, Inc. | 391,476 | 519,120 | +127,644 | 0.06 | 0.10 | +0.04 | buy |
| Woodline Partners LP | 513,828 | 513,828 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Holocene Advisors, LP | 0 | 510,000 | +510,000 | 0.00 | 0.01 | +0.01 | buy |
| Ghisallo Capital Management LLC | 0 | 505,000 | +505,000 | 0.00 | 0.07 | +0.07 | buy |
| Burkehill Global Management, LP | 0 | 500,000 | +500,000 | 0.00 | 0.12 | +0.12 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 319,748 | 489,219 | +169,471 | 0.01 | 0.03 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 490,472 | 464,771 | -25,701 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 511,983 | 425,363 | -86,620 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 0 | 379,577 | +379,577 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 268,800 | 369,000 | +100,200 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 328,831 | 358,374 | +29,543 | 0.05 | 0.06 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 183,334 | 333,314 | +149,980 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 479,000 | 328,800 | -150,200 | 0.03 | 0.02 | -0.01 | sell |
| CITIGROUP INC | 57,080 | 306,907 | +249,827 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 258,530 | 299,975 | +41,445 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 222,986 | 290,543 | +67,557 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 265,795 | 272,600 | +6,805 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 368,021 | 264,379 | -103,642 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 275,111 | 262,896 | -12,215 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 259,605 | +259,605 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 250,000 | +250,000 | 0.00 | 0.24 | +0.24 | buy |
| ALLIANCEBERNSTEIN L.P. | 189,240 | 247,680 | +58,440 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 181,769 | 243,379 | +61,610 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 742,081 | 234,716 | -507,365 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 228,355 | +228,355 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 170,751 | 222,347 | +51,596 | 0.03 | 0.03 | +0.00 | buy |
| SG Americas Securities, LLC | 2,176,742 | 202,260 | -1,974,482 | 0.01 | 0.00 | -0.01 | sell |
| Monashee Investment Management LLC | 0 | 200,000 | +200,000 | 0.00 | 2.29 | +2.29 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 158,954 | 199,494 | +40,540 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 181,900 | 198,900 | +17,000 | 0.17 | 0.25 | +0.08 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 195,745 | 197,578 | +1,833 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 83,019 | 189,332 | +106,313 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 263,332 | 177,089 | -86,243 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,933 | 169,374 | +32,441 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 22,031 | 166,042 | +144,011 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 160,654 | 160,654 | 0 | 0.12 | 0.15 | +0.03 | hold |
| Rafferty Asset Management, LLC | 299,903 | 154,706 | -145,197 | 0.01 | 0.00 | -0.00 | sell |
| Palumbo Wealth Management LLC | 146,709 | 149,173 | +2,464 | 0.16 | 0.21 | +0.05 | buy |
| MetLife Investment Management, LLC | 120,116 | 140,846 | +20,730 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 133,411 | +133,411 | 0.00 | 0.29 | +0.29 | buy |
| AQR CAPITAL MANAGEMENT LLC | 177,309 | 128,764 | -48,545 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 124,730 | 127,915 | +3,185 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 116,582 | +116,582 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 39,856 | 108,208 | +68,352 | 0.01 | 0.03 | +0.02 | buy |
| Legal & General Group Plc | 104,308 | 108,207 | +3,899 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 108,399 | 106,290 | -2,109 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 0 | 104,132 | +104,132 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 99,371 | 104,095 | +4,724 | 0.00 | 0.00 | +0.00 | buy |