| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 25,021,584 | 24,354,291 | -667,293 | 0.82 | 0.98 | +0.16 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 23,555,648 | 23,555,648 | 0 | 0.92 | 0.95 | +0.03 | hold |
| Avoro Capital Advisors LLC | 21,700,000 | 21,700,000 | 0 | 0.88 | 0.92 | +0.04 | hold |
| MORGAN STANLEY | 16,865,082 | 19,307,603 | +2,442,521 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 13,303,775 | 16,364,861 | +3,061,086 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 15,627,822 | 14,593,412 | -1,034,410 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 12,587,700 | 13,383,708 | +796,008 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 10,894,127 | 12,849,613 | +1,955,486 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 11,014,737 | 11,014,737 | 0 | 1.32 | 1.41 | +0.09 | hold |
| Octagon Capital Advisors LP | 12,592,500 | 9,067,500 | -3,525,000 | 6.38 | 4.63 | -1.76 | sell |
| Point72 Asset Management, L.P. | 7,317,614 | 7,331,470 | +13,856 | 0.04 | 0.05 | +0.01 | buy |
| STATE STREET CORP | 5,138,310 | 7,236,465 | +2,098,155 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 3,000,000 | 5,500,000 | +2,500,000 | 0.36 | 0.82 | +0.45 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,386,000 | 5,386,000 | 0 | 0.23 | 0.27 | +0.04 | hold |
| Polar Capital Holdings Plc | 5,000,000 | 5,293,879 | +293,879 | 0.06 | 0.08 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,793,572 | 5,174,516 | +1,380,944 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 450,501 | 5,148,112 | +4,697,611 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,935,728 | 4,026,122 | +1,090,394 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.09 | 0.09 | +0.00 | hold |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 4,095,000 | 3,700,000 | -395,000 | 27.39 | 39.11 | +11.73 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,839,000 | 3,328,000 | -1,511,000 | 0.02 | 0.02 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 200,000 | 3,000,000 | +2,800,000 | 0.07 | 0.91 | +0.84 | buy |
| ADAR1 Capital Management, LLC | 3,009,870 | 2,835,680 | -174,190 | 1.13 | 0.92 | -0.21 | sell |
| D. E. Shaw & Co., Inc. | 401,509 | 2,706,434 | +2,304,925 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 10,313,733 | 2,156,642 | -8,157,091 | 0.39 | 0.06 | -0.33 | sell |
| TORONTO DOMINION BANK | 4,728,806 | 1,923,962 | -2,804,844 | 0.02 | 0.01 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 0 | 1,898,112 | +1,898,112 | 0.00 | 5.20 | +5.20 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 491,709 | 1,846,510 | +1,354,801 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 1,800,556 | 1,800,556 | 0 | 3.59 | 5.63 | +2.04 | hold |
| NORTHERN TRUST CORP | 1,328,741 | 1,717,178 | +388,437 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,500,000 | 1,500,000 | 0 | 2.25 | 2.05 | -0.21 | hold |
| BANK OF AMERICA CORP /DE/ | 730,728 | 1,307,287 | +576,559 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 1,246,033 | 1,246,033 | 0 | 0.61 | 0.75 | +0.14 | hold |
| Granahan Investment Management, LLC | 958,493 | 1,116,629 | +158,136 | 0.09 | 0.15 | +0.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | 900,000 | 0 | 0.11 | 0.11 | +0.01 | hold |
| STEMPOINT CAPITAL LP | 1,203,941 | 839,669 | -364,272 | 0.90 | 0.55 | -0.34 | sell |
| Quantum Private Wealth, LLC | 815,976 | 822,076 | +6,100 | 0.61 | 0.79 | +0.18 | buy |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.33 | 0.52 | +0.19 | hold |
| Alphabet Inc. | 640,882 | 640,882 | 0 | 0.07 | 0.09 | +0.02 | hold |
| UBS Group AG | 261,239 | 639,356 | +378,117 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 458,659 | 624,839 | +166,180 | 0.00 | 0.00 | +0.00 | buy |
| Anson Funds Management LP | 803,500 | 603,500 | -200,000 | 0.34 | 0.22 | -0.12 | sell |
| ROYAL BANK OF CANADA | 495,311 | 583,375 | +88,064 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 578,118 | +578,118 | 0.00 | 0.10 | +0.10 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 635,968 | 568,006 | -67,962 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 136,994 | 556,785 | +419,791 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 465,144 | 507,210 | +42,066 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,000,254 | 500,000 | -500,254 | 0.01 | 0.01 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 44,690 | 477,749 | +433,059 | 0.01 | 0.13 | +0.12 | buy |
| MARSHALL WACE, LLP | 79,498 | 476,865 | +397,367 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 485,669 | 454,827 | -30,842 | 1.57 | 1.54 | -0.03 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 415,607 | +415,607 | 0.00 | 0.03 | +0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 420,000 | 408,146 | -11,854 | 0.25 | 0.32 | +0.06 | sell |
| CITADEL ADVISORS LLC | 528,993 | 367,309 | -161,684 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 0 | 345,163 | +345,163 | 0.00 | 0.00 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 298,667 | 298,667 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JPMORGAN CHASE & CO | 222,649 | 296,244 | +73,595 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 233,256 | 288,859 | +55,603 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 203,671 | 279,793 | +76,122 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 118,683 | 239,785 | +121,102 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 100,226 | 198,352 | +98,126 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 179,620 | 179,640 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 163,766 | 164,037 | +271 | 0.01 | 0.02 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 161,972 | +161,972 | 0.00 | 0.03 | +0.03 | buy |
| Palumbo Wealth Management LLC | 0 | 157,353 | +157,353 | 0.00 | 0.16 | +0.16 | buy |
| AQR CAPITAL MANAGEMENT LLC | 135,766 | 151,000 | +15,234 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 107,234 | 145,098 | +37,864 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 134,900 | 134,900 | 0 | 0.07 | 0.08 | +0.01 | hold |
| MetLife Investment Management, LLC | 108,078 | 127,044 | +18,966 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 107,716 | 122,799 | +15,083 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 84,603 | 113,835 | +29,232 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 96,543 | 111,024 | +14,481 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 108,399 | 108,399 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mitsubishi UFJ Asset Management Co., Ltd. | 80,571 | 80,732 | +161 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,005 | 69,857 | +8,852 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 82,195 | 68,626 | -13,569 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,100 | 67,600 | +46,500 | 0.00 | 0.00 | +0.00 | buy |
| Militia Capital Partners, LP | 66,800 | 66,800 | 0 | 0.07 | 0.10 | +0.03 | hold |
| TWO SIGMA INVESTMENTS, LP | 32,682 | 66,105 | +33,423 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 60,036 | 58,257 | -1,779 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 45,678 | 57,168 | +11,490 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 64,617 | 53,483 | -11,134 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 26,599 | 53,366 | +26,767 | 0.00 | 0.01 | +0.00 | buy |
| Jain Global LLC | 0 | 52,608 | +52,608 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 51,981 | 52,226 | +245 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 57,000 | 49,677 | -7,323 | 0.04 | 0.06 | +0.02 | sell |
| Virtu Financial LLC | 0 | 48,123 | +48,123 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 52,527 | 47,817 | -4,710 | 0.01 | 0.01 | +0.00 | sell |
| Quadrature Capital Ltd | 161,940 | 47,328 | -114,612 | 0.01 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 46,643 | +46,643 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 43,746 | 46,039 | +2,293 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 18,591 | 46,034 | +27,443 | 0.00 | 0.00 | +0.00 | buy |
| Williams & Novak, LLC | 45,000 | 45,000 | 0 | 0.09 | 0.11 | +0.02 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 42,949 | +42,949 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 35,484 | 42,938 | +7,454 | 0.03 | 0.04 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 38,556 | +38,556 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,169 | 36,500 | -10,669 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 130,317 | 33,495 | -96,822 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 493,301 | 32,949 | -460,352 | 0.01 | 0.00 | -0.00 | sell |
| FIRST MANHATTAN CO. LLC. | 28,500 | 28,500 | 0 | 0.00 | 0.00 | +0.00 | hold |