| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 0 | 3,380,532 | +3,380,532 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 2,297,556 | +2,297,556 | 0.00 | 0.00 | +0.00 | buy |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | 1,500,000 | 3,700,000 | +2,200,000 | 0.66 | 0.98 | +0.31 | buy |
| Eversept Partners, LP | 1,705,774 | 3,780,714 | +2,074,940 | 0.60 | 0.66 | +0.06 | buy |
| Point72 Asset Management, L.P. | 936,550 | 2,688,000 | +1,751,450 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 2,504,756 | 4,004,756 | +1,500,000 | 0.05 | 0.08 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 202,617 | 1,428,146 | +1,225,529 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 5,327,864 | 6,195,567 | +867,703 | 0.00 | 0.00 | -0.00 | buy |
| Palo Alto Investors LP | 0 | 529,861 | +529,861 | 0.00 | 0.08 | +0.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 461,666 | 985,421 | +523,755 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 598,000 | 1,097,400 | +499,400 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 460,066 | +460,066 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 3,925,000 | 4,355,555 | +430,555 | 0.19 | 0.11 | -0.09 | buy |
| Schonfeld Strategic Advisors LLC | 720,043 | 1,119,375 | +399,332 | 0.02 | 0.02 | -0.00 | buy |
| Monaco Asset Management SAM | 0 | 295,000 | +295,000 | 0.00 | 0.20 | +0.20 | buy |
| Kovitz Investment Group Partners, LLC | 25,000 | 277,778 | +252,778 | 0.00 | 0.01 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 0 | 186,700 | +186,700 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 66,190 | 213,721 | +147,531 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 136,973 | +136,973 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 118,521 | +118,521 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 83,474 | +83,474 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Private Wealth, LLC | 575,380 | 639,520 | +64,140 | 0.87 | 0.47 | -0.40 | buy |
| Cubist Systematic Strategies, LLC | 0 | 48,434 | +48,434 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 35,400 | +35,400 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 28,568 | 63,477 | +34,909 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 26,074 | 58,140 | +32,066 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 281,119 | 310,963 | +29,844 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 28,477 | +28,477 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 26,070 | +26,070 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 111,111 | 134,851 | +23,740 | 0.01 | 0.01 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 21,696 | +21,696 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 21,622 | +21,622 | 0.00 | 0.01 | +0.01 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 17,389 | +17,389 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 16,285 | +16,285 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 15,600 | +15,600 | 0.00 | 0.00 | +0.00 | buy |
| Howard Capital Management Inc. | 0 | 14,165 | +14,165 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,946 | +11,946 | 0.00 | 0.00 | +0.00 | buy |
| Camelot Portfolios, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| Royal Capital Wealth Management, LLC | 0 | 10,665 | +10,665 | 0.00 | 0.02 | +0.02 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 8,805 | +8,805 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 8,000 | +8,000 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 5,622 | 12,032 | +6,410 | 0.00 | 0.00 | -0.00 | buy |
| Redwood Wealth Management Group, LLC | 38,200 | 42,600 | +4,400 | 0.14 | 0.08 | -0.06 | buy |
| STATE STREET CORP | 140,020 | 143,220 | +3,200 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,871 | +2,871 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 17,250 | 19,050 | +1,800 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 56,935 | 58,060 | +1,125 | 0.00 | 0.00 | -0.00 | buy |
| Morton Brown Family Wealth, LLC | 0 | 260 | +260 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 3,663,104 | 3,663,104 | 0 | 0.50 | 0.22 | -0.28 | hold |
| TD ASSET MANAGEMENT INC | 175,600 | 175,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 18,472,503 | 18,472,503 | 0 | 1.15 | 0.51 | -0.64 | hold |
| Lee Financial Co | 20,000 | 20,000 | 0 | 0.01 | 0.01 | -0.01 | hold |
| RTW INVESTMENTS, LP | 16,893,185 | 16,893,185 | 0 | 1.13 | 0.47 | -0.66 | hold |
| Allworth Financial LP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Investment Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 79 | 79 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Dynamic Advisor Solutions LLC | 45,000 | 45,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 640,882 | 640,882 | 0 | 0.13 | 0.05 | -0.08 | hold |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.68 | 0.36 | -0.32 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,140 | 16,140 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,547 | 61,547 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,971 | 26,769 | -202 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 27,637 | 17,202 | -10,435 | 0.00 | 0.00 | -0.00 | sell |
| Polar Capital Holdings Plc | 2,530,000 | 2,518,909 | -11,091 | 0.06 | 0.03 | -0.03 | sell |
| SIMPLEX TRADING, LLC | 14,639 | 0 | -14,639 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,247,471 | 1,227,333 | -20,138 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 240,251 | 189,876 | -50,375 | 0.07 | 0.03 | -0.04 | sell |
| Verition Fund Management LLC | 85,034 | 0 | -85,034 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 156,300 | 0 | -156,300 | 0.01 | 0.00 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 3,827,926 | 3,589,333 | -238,593 | 8.80 | 3.58 | -5.22 | sell |
| Informed Momentum Co LLC | 335,390 | 0 | -335,390 | 0.20 | 0.00 | -0.20 | sell |
| Diametric Capital, LP | 760,014 | 68,871 | -691,143 | 1.00 | 0.07 | -0.93 | sell |
| FRANKLIN RESOURCES INC | 810,840 | 0 | -810,840 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,500,000 | 420,000 | -1,080,000 | 0.01 | 0.00 | -0.01 | sell |
| FMR LLC | 24,527,801 | 22,439,124 | -2,088,677 | 0.01 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 2,777,778 | 0 | -2,777,778 | 1.55 | 0.00 | -1.55 | sell |
| Kynam Capital Management, LP | 3,281,313 | 0 | -3,281,313 | 1.72 | 0.00 | -1.72 | sell |
| VR Adviser, LLC | 14,444,444 | 10,412,872 | -4,031,572 | 4.80 | 1.26 | -3.54 | sell |
| TCG Crossover Management, LLC | 11,111,111 | 2,912,861 | -8,198,250 | 5.17 | 0.57 | -4.60 | sell |