| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 5,500,000 | 13,750,000 | +8,250,000 | 0.82 | 2.77 | +1.96 | buy |
| Polar Capital Holdings Plc | 5,293,879 | 7,931,403 | +2,637,524 | 0.08 | 0.20 | +0.12 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 578,118 | 1,270,645 | +692,527 | 0.10 | 0.38 | +0.28 | buy |
| Affinity Asset Advisors, LLC | 3,000,000 | 3,300,000 | +300,000 | 0.91 | 1.30 | +0.39 | buy |
| GSA CAPITAL PARTNERS LLP | 477,749 | 208,016 | +269,733 | 0.15 | 0.11 | 0.00 | sell |
| WEXFORD CAPITAL LP | 3,500 | 180,853 | +177,353 | 0.00 | 0.19 | +0.19 | buy |
| Rafferty Asset Management, LLC | 239,785 | 344,784 | +104,999 | 0.00 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 134,900 | 164,900 | +30,000 | 0.08 | 0.17 | +0.09 | buy |
| Palumbo Wealth Management LLC | 157,353 | 178,007 | +20,654 | 0.16 | 0.24 | +0.08 | buy |
| FIRST MANHATTAN CO. LLC. | 28,500 | 43,500 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Allegheny Financial Group | 15,000 | 26,350 | +11,350 | 0.01 | 0.02 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 42,938 | 45,946 | +3,008 | 0.04 | 0.07 | +0.03 | buy |
| GF FUND MANAGEMENT CO. LTD. | 5,869 | 5,383 | -486 | 0.00 | 0.00 | +0.00 | sell |
| Quantum Private Wealth, LLC | 822,076 | 819,715 | -2,361 | 0.79 | 1.32 | +0.53 | sell |
| China Universal Asset Management Co., Ltd. | 47,817 | 44,635 | -3,182 | 0.01 | 0.02 | +0.01 | sell |
| AXQ CAPITAL, LP | 49,677 | 37,804 | -11,873 | 0.06 | 0.05 | -0.02 | sell |
| Militia Capital Partners, LP | 66,800 | 46,500 | -20,300 | 0.10 | 0.10 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 408,146 | 368,146 | -40,000 | 0.28 | 0.39 | +0.11 | sell |
| Palo Alto Investors LP | 1,246,033 | 1,183,195 | -62,838 | 0.75 | 0.91 | +0.15 | sell |
| Octagon Capital Advisors LP | 9,067,500 | 8,859,911 | -207,589 | 4.63 | 6.10 | +1.47 | sell |
| ADAR1 Capital Management, LLC | 2,835,680 | 2,495,809 | -339,871 | 0.92 | 1.03 | +0.11 | sell |
| Granahan Investment Management, LLC | 1,116,629 | 703,971 | -412,658 | 0.15 | 0.17 | +0.02 | sell |
| STEMPOINT CAPITAL LP | 839,669 | 182,130 | -657,539 | 0.55 | 0.17 | -0.38 | sell |
| Siren, L.L.C. | 11,014,737 | 10,129,913 | -884,824 | 1.41 | 1.66 | +0.25 | sell |
| Ally Bridge Group (NY) LLC | 1,898,112 | 457,132 | -1,440,980 | 5.20 | 3.99 | -1.21 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,328,000 | 1,328,000 | -2,000,000 | 0.02 | 0.01 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,386,000 | 2,722,165 | -2,663,835 | 0.27 | 0.19 | -0.08 | sell |
| RTW INVESTMENTS, LP | 24,354,291 | 16,398,297 | -7,955,994 | 0.98 | 0.90 | -0.08 | sell |