| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 23,555,648 | 23,555,648 | 0 | 0.95 | 1.33 | +0.38 | hold |
| Avoro Capital Advisors LLC | 21,700,000 | 21,700,000 | 0 | 0.92 | 1.17 | +0.26 | hold |
| BlackRock, Inc. | 16,364,861 | 18,643,129 | +2,278,268 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 19,307,603 | 18,078,518 | -1,229,085 | 0.00 | 0.01 | +0.00 | sell |
| RTW INVESTMENTS, LP | 24,354,291 | 16,398,297 | -7,955,994 | 0.98 | 0.90 | -0.08 | sell |
| Vestal Point Capital, LP | 5,500,000 | 13,750,000 | +8,250,000 | 0.82 | 2.77 | +1.96 | buy |
| GOLDMAN SACHS GROUP INC | 13,383,708 | 13,692,739 | +309,031 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 14,593,412 | 13,528,366 | -1,065,046 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 12,849,613 | 13,267,805 | +418,192 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 7,236,465 | 10,790,084 | +3,553,619 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 11,014,737 | 10,129,913 | -884,824 | 1.41 | 1.66 | +0.25 | sell |
| Octagon Capital Advisors LP | 9,067,500 | 8,859,911 | -207,589 | 4.63 | 6.10 | +1.47 | sell |
| Polar Capital Holdings Plc | 5,293,879 | 7,931,403 | +2,637,524 | 0.08 | 0.20 | +0.12 | buy |
| BARCLAYS PLC | 5,148,112 | 5,539,001 | +390,889 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,174,516 | 5,387,026 | +212,510 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 2,706,434 | 4,013,635 | +1,307,201 | 0.01 | 0.02 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 4,004,756 | 4,004,756 | 0 | 0.09 | 0.13 | +0.03 | hold |
| Point72 Asset Management, L.P. | 7,331,470 | 3,868,682 | -3,462,788 | 0.05 | 0.03 | -0.02 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 3,722,000 | +3,722,000 | 0.00 | 0.03 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 3,000,000 | 3,300,000 | +300,000 | 0.91 | 1.30 | +0.39 | buy |
| MILLENNIUM MANAGEMENT LLC | 4,026,122 | 3,178,863 | -847,259 | 0.01 | 0.01 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,386,000 | 2,722,165 | -2,663,835 | 0.27 | 0.19 | -0.08 | sell |
| ADAR1 Capital Management, LLC | 2,835,680 | 2,495,809 | -339,871 | 0.92 | 1.03 | +0.11 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,846,510 | 1,902,978 | +56,468 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 367,309 | 1,854,855 | +1,487,546 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 0 | 1,837,800 | +1,837,800 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 1,800,556 | 1,800,556 | 0 | 5.63 | 7.34 | +1.71 | hold |
| Casdin Capital, LLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.51 | +0.51 | buy |
| Invesco Ltd. | 279,793 | 1,332,780 | +1,052,987 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,328,000 | 1,328,000 | -2,000,000 | 0.02 | 0.01 | -0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 578,118 | 1,270,645 | +692,527 | 0.10 | 0.38 | +0.28 | buy |
| NORTHERN TRUST CORP | 1,717,178 | 1,237,987 | -479,191 | 0.00 | 0.00 | +0.00 | sell |
| Palo Alto Investors LP | 1,246,033 | 1,183,195 | -62,838 | 0.75 | 0.91 | +0.15 | sell |
| BANK OF AMERICA CORP /DE/ | 1,307,287 | 1,152,680 | -154,607 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 0 | 1,021,063 | +1,021,063 | 0.00 | 0.01 | +0.01 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 980,768 | +980,768 | 0.00 | 2.89 | +2.89 | buy |
| Informed Momentum Co LLC | 0 | 823,758 | +823,758 | 0.00 | 0.50 | +0.50 | buy |
| Quantum Private Wealth, LLC | 822,076 | 819,715 | -2,361 | 0.79 | 1.32 | +0.53 | sell |
| SG Americas Securities, LLC | 32,949 | 781,474 | +748,525 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 296,244 | 774,412 | +478,168 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 724,873 | 724,873 | 0 | 0.52 | 0.77 | +0.25 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 568,006 | 711,235 | +143,229 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 1,116,629 | 703,971 | -412,658 | 0.15 | 0.17 | +0.02 | sell |
| Bank of New York Mellon Corp | 624,839 | 624,367 | -472 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 507,210 | 545,286 | +38,076 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 500,000 | 500,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 345,163 | 490,472 | +145,309 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 198,352 | 471,577 | +273,225 | 0.00 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 1,898,112 | 457,132 | -1,440,980 | 5.20 | 3.99 | -1.21 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 454,827 | 454,827 | 0 | 1.54 | 1.70 | +0.16 | hold |
| HRT FINANCIAL LP | 0 | 409,254 | +409,254 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 639,356 | 383,043 | -256,313 | 0.00 | 0.00 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 408,146 | 368,146 | -40,000 | 0.32 | 0.42 | +0.11 | sell |
| TWO SIGMA INVESTMENTS, LP | 66,105 | 351,126 | +285,021 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 239,785 | 344,784 | +104,999 | 0.00 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 415,607 | 309,481 | -106,126 | 0.03 | 0.04 | +0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 0 | 308,457 | +308,457 | 0.00 | 0.06 | +0.06 | buy |
| WELLS FARGO & COMPANY/MN | 145,098 | 305,086 | +159,988 | 0.00 | 0.00 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 300,000 | +300,000 | 0.00 | 0.40 | +0.40 | buy |
| Focus Partners Wealth | 0 | 295,516 | +295,516 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 38,556 | 288,535 | +249,979 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 275,111 | +275,111 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 268,800 | +268,800 | 0.00 | 0.00 | +0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 0 | 265,000 | +265,000 | 0.00 | 0.96 | +0.96 | buy |
| NOMURA HOLDINGS INC | 0 | 259,339 | +259,339 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 288,859 | 257,440 | -31,419 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 0 | 224,920 | +224,920 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 36,500 | 218,185 | +181,685 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 477,749 | 208,016 | -269,733 | 0.13 | 0.10 | -0.03 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 25,600 | 195,764 | +170,164 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 839,669 | 182,130 | -657,539 | 0.55 | 0.17 | -0.38 | sell |
| WEXFORD CAPITAL LP | 3,500 | 180,853 | +177,353 | 0.00 | 0.26 | +0.25 | buy |
| ALLIANCEBERNSTEIN L.P. | 179,640 | 179,640 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Palumbo Wealth Management LLC | 157,353 | 178,007 | +20,654 | 0.16 | 0.24 | +0.08 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 46,034 | 172,482 | +126,448 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 171,100 | +171,100 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 151,000 | 168,862 | +17,862 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 167,500 | +167,500 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 164,037 | 166,541 | +2,504 | 0.02 | 0.02 | -0.00 | buy |
| Privium Fund Management B.V. | 134,900 | 164,900 | +30,000 | 0.08 | 0.17 | +0.09 | buy |
| JANE STREET GROUP, LLC | 556,785 | 163,146 | -393,639 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 122,799 | 160,779 | +37,980 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 156,586 | +156,586 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 139,581 | +139,581 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,373 | 138,580 | +128,207 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 23,149 | 133,146 | +109,997 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 53,366 | 128,590 | +75,224 | 0.01 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 124,975 | +124,975 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 111,024 | 122,639 | +11,615 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 113,835 | 121,814 | +7,979 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 127,044 | 113,266 | -13,778 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 42,949 | 113,178 | +70,229 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 108,399 | 108,399 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 28,345 | 86,730 | +58,385 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 68,626 | 71,069 | +2,443 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 69,000 | +69,000 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 68,900 | +68,900 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 67,600 | 67,500 | -100 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 67,477 | +67,477 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,857 | 67,085 | -2,772 | 0.00 | 0.00 | +0.00 | sell |