| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARCH Venture Management, LLC | 2,759,072 | 3,247,162 | +488,090 | 13.03 | 9.62 | -3.41 | buy |
| MILLENNIUM MANAGEMENT LLC | 58,651 | 458,905 | +400,254 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,016 | 310,198 | +159,182 | 0.01 | 0.01 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 102,000 | +102,000 | 0.00 | 1.28 | +1.28 | buy |
| Opaleye Management Inc. | 0 | 79,097 | +79,097 | 0.00 | 0.21 | +0.21 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 39,490 | 116,411 | +76,921 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 73,315 | 148,516 | +75,201 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 324,701 | 381,462 | +56,761 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 12,409 | 63,893 | +51,484 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 47,888 | +47,888 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 9,051 | 55,110 | +46,059 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 39,916 | +39,916 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 33,321 | +33,321 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 22,207 | +22,207 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 51,472 | 72,522 | +21,050 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 20,123 | +20,123 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 19,294 | +19,294 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 13,203 | 31,814 | +18,611 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 96,675 | 114,491 | +17,816 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 15,971 | +15,971 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 13,435 | +13,435 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 181,837 | 191,820 | +9,983 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 11,480 | 21,292 | +9,812 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 162,997 | 166,980 | +3,983 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 4,233 | 5,912 | +1,679 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 37 | 693 | +656 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 648 | +648 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 85,423 | 85,971 | +548 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 447 | +447 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,457 | 3,770 | +313 | 0.01 | 0.01 | -0.00 | buy |
| Seneschal Advisors, LLC | 0 | 126 | +126 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,194 | 1,301 | +107 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,031 | 1,108 | +77 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 416 | 470 | +54 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 0 | 43 | +43 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,000 | 18,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Advisors Asset Management, Inc. | 567 | 567 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSG Holding Ltd | 152,299 | 152,299 | 0 | 0.21 | 0.00 | -0.20 | hold |
| Orland Properties Ltd | 754,698 | 754,698 | 0 | 4.35 | 5.67 | +1.33 | hold |
| Almitas Capital LLC | 577,807 | 577,807 | 0 | 3.92 | 2.62 | -1.30 | hold |
| Alphabet Inc. | 293,256 | 293,256 | 0 | 0.35 | 0.15 | -0.20 | hold |
| Foresite Capital Management IV, LLC | 800,399 | 800,399 | 0 | 10.72 | 6.77 | -3.95 | hold |
| venBio Partners LLC | 337,697 | 337,697 | 0 | 4.81 | 2.41 | -2.39 | hold |
| Ikarian Capital, LLC | 41,081 | 41,081 | 0 | 0.16 | 0.12 | -0.05 | hold |
| Foresite Capital Management V, LLC | 477,078 | 477,078 | 0 | 8.93 | 3.53 | -5.40 | hold |
| MIC Capital Management UK LLP | 87,028 | 87,028 | 0 | 0.61 | 0.50 | -0.11 | hold |
| Susquehanna Portfolio Strategies, LLC | 20,800 | 20,800 | 0 | 0.01 | 0.01 | -0.00 | hold |
| GAMMA Investing LLC | 35 | 35 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Decheng Capital LLC | 692,050 | 692,050 | 0 | 2.87 | 2.10 | -0.77 | hold |
| US BANCORP \DE\ | 58 | 58 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 30,280 | 30,280 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,128 | 13,128 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 1,025 | 1,025 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 1,829 | 1,823 | -6 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 45 | 0 | -45 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,170 | 2,097 | -1,073 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,657 | 0 | -1,657 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 32,111 | 29,411 | -2,700 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 15,616 | 11,585 | -4,031 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 7,617 | 0 | -7,617 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 7,900 | 0 | -7,900 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 8,511 | 0 | -8,511 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 9,516 | 0 | -9,516 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 15,967 | 1,671 | -14,296 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 74,585 | 44,094 | -30,491 | 0.10 | 0.04 | -0.06 | sell |
| JOHNSON & JOHNSON | 54,887 | 0 | -54,887 | 0.30 | 0.00 | -0.30 | sell |
| Invesco Ltd. | 98,649 | 0 | -98,649 | 0.00 | 0.00 | -0.00 | sell |