| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 191,820 | 724,342 | +532,522 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 79,097 | 344,025 | +264,928 | 0.21 | 0.44 | +0.23 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 166,980 | 310,636 | +143,656 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 72,522 | 185,322 | +112,800 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 107,570 | +107,570 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 30,280 | 118,500 | +88,220 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 59,748 | +59,748 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 55,110 | 110,531 | +55,421 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 11,585 | 52,927 | +41,342 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 36,575 | +36,575 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 26,225 | +26,225 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 0 | 24,673 | +24,673 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 19,294 | 42,322 | +23,028 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 85,971 | 107,570 | +21,599 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 47,888 | 68,315 | +20,427 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 19,410 | +19,410 | 0.00 | 0.07 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,128 | 30,657 | +17,529 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 16,145 | +16,145 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 15,462 | +15,462 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 13,914 | +13,914 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 116,411 | 130,190 | +13,779 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 0 | 12,595 | +12,595 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 11,602 | +11,602 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 9,505 | +9,505 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 9,188 | +9,188 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 15,971 | 24,540 | +8,569 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,097 | 7,845 | +5,748 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 21,292 | 26,080 | +4,788 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 4,333 | +4,333 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| Almitas Capital LLC | 577,807 | 581,407 | +3,600 | 2.62 | 1.96 | -0.66 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 3,446 | +3,446 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,671 | 4,715 | +3,044 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 102,000 | 105,000 | +3,000 | 1.28 | 0.90 | -0.38 | buy |
| Jump Financial, LLC | 20,123 | 21,956 | +1,833 | 0.01 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 0 | 917 | +917 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 854 | +854 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 447 | 905 | +458 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,823 | 2,151 | +328 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 190 | +190 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 179 | +179 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,301 | 1,364 | +63 | 0.00 | 0.00 | -0.00 | buy |
| Optiver Holding B.V. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,000 | 18,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ARCH Venture Management, LLC | 3,247,162 | 3,247,162 | 0 | 9.62 | 4.14 | -5.48 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,411 | 29,411 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSG Holding Ltd | 152,299 | 152,299 | 0 | 0.00 | 0.18 | +0.17 | hold |
| Orland Properties Ltd | 754,698 | 754,698 | 0 | 5.67 | 5.25 | -0.43 | hold |
| Alphabet Inc. | 293,256 | 293,256 | 0 | 0.15 | 0.00 | -0.14 | hold |
| venBio Partners LLC | 337,697 | 337,697 | 0 | 2.41 | 0.91 | -1.50 | hold |
| Ikarian Capital, LLC | 41,081 | 41,081 | 0 | 0.12 | 0.09 | -0.02 | hold |
| MIC Capital Management UK LLP | 87,028 | 87,028 | 0 | 0.50 | 0.31 | -0.19 | hold |
| GAMMA Investing LLC | 35 | 35 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Decheng Capital LLC | 692,050 | 692,050 | 0 | 2.10 | 1.33 | -0.77 | hold |
| US BANCORP \DE\ | 58 | 58 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 1,025 | 1,025 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 100 | 88 | -12 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 470 | 452 | -18 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 43 | 0 | -43 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 3,770 | 3,714 | -56 | 0.01 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,108 | 1,044 | -64 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Seneschal Advisors, LLC | 126 | 0 | -126 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 693 | 226 | -467 | 0.00 | 0.00 | -0.00 | sell |
| Advisors Asset Management, Inc. | 567 | 0 | -567 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 648 | 0 | -648 | 0.00 | 0.00 | -0.00 | sell |
| Foresite Capital Management V, LLC | 477,078 | 476,386 | -692 | 3.53 | 1.85 | -1.68 | sell |
| CITIGROUP INC | 5,912 | 5,025 | -887 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 13,435 | 11,557 | -1,878 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 20,800 | 17,875 | -2,925 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 22,207 | 10,451 | -11,756 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 63,893 | 46,011 | -17,882 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 39,916 | 19,958 | -19,958 | 0.01 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 114,491 | 86,779 | -27,712 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 31,814 | 0 | -31,814 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 33,321 | 0 | -33,321 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 148,516 | 106,300 | -42,216 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 44,094 | 0 | -44,094 | 0.04 | 0.00 | -0.04 | sell |
| MILLENNIUM MANAGEMENT LLC | 458,905 | 367,473 | -91,432 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 310,198 | 0 | -310,198 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 381,462 | 0 | -381,462 | 0.01 | 0.00 | -0.01 | sell |
| Foresite Capital Management IV, LLC | 800,399 | 0 | -800,399 | 6.77 | 0.00 | -6.77 | sell |