| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MWG Management Ltd. | 0 | 1,008,116 | +1,008,116 | 0.00 | 20.13 | +20.13 | buy |
| ARCH Venture Management, LLC | 1,820,634 | 2,759,072 | +938,438 | 5.39 | 9.10 | +3.71 | buy |
| Orland Properties Ltd | 0 | 754,698 | +754,698 | 0.00 | 2.62 | +2.62 | buy |
| VANGUARD GROUP INC | 442,626 | 779,004 | +336,378 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 52,229 | 125,361 | +73,132 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management V, LLC | 406,652 | 477,078 | +70,426 | 4.45 | 7.12 | +2.67 | buy |
| CITADEL ADVISORS LLC | 271,283 | 339,491 | +68,208 | 0.00 | 0.00 | +0.00 | buy |
| JOHNSON & JOHNSON | 0 | 54,887 | +54,887 | 0.00 | 0.18 | +0.18 | buy |
| BlackRock, Inc. | 144,859 | 176,806 | +31,947 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 103,270 | 130,257 | +26,987 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 61,503 | 79,510 | +18,007 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 16,159 | +16,159 | 0.00 | 0.00 | +0.00 | buy |
| TAKEDA PHARMACEUTICAL CO LTD | 41,165 | 54,887 | +13,722 | 1.86 | 5.45 | +3.58 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,059 | 20,827 | +10,768 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 10,275 | +10,275 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.15 | +0.15 | buy |
| NORTHERN TRUST CORP | 18,644 | 28,128 | +9,484 | 0.00 | 0.00 | +0.00 | buy |
| Clarius Group, LLC | 19,138 | 19,958 | +820 | 0.01 | 0.02 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 413 | +413 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,966 | 3,367 | +401 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 570 | 743 | +173 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,155 | 1,192 | +37 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 353 | 355 | +2 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ORBIMED ADVISORS LLC | 51,727 | 51,727 | 0 | 0.01 | 0.02 | +0.01 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,000 | 18,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,411 | 29,411 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSG Holding Ltd | 152,299 | 152,299 | 0 | 0.07 | 0.00 | -0.07 | hold |
| Daiwa Securities Group Inc. | 45 | 45 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 12,234 | 12,234 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Alphabet Inc. | 293,256 | 293,256 | 0 | 0.12 | 0.20 | +0.08 | hold |
| Foresite Capital Management IV, LLC | 800,399 | 800,399 | 0 | 5.72 | 7.12 | +1.40 | hold |
| venBio Partners LLC | 473,479 | 473,479 | 0 | 3.65 | 4.36 | +0.71 | hold |
| Ikarian Capital, LLC | 43,799 | 43,799 | 0 | 0.13 | 0.14 | +0.02 | hold |
| MIC Capital Management UK LLP | 87,028 | 87,028 | 0 | 0.15 | 0.28 | +0.13 | hold |
| GAMMA Investing LLC | 35 | 35 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Decheng Capital LLC | 595,466 | 595,466 | 0 | 1.33 | 1.69 | +0.36 | hold |
| US BANCORP \DE\ | 58 | 58 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 3 | 1 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Advisors Asset Management, Inc. | 575 | 567 | -8 | 0.00 | 0.00 | +0.00 | sell |
| True Wealth Design, LLC | 23 | 0 | -23 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 63 | 0 | -63 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 33,847 | 33,752 | -95 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 298 | 162 | -136 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,103 | 1,858 | -245 | 0.00 | 0.00 | +0.00 | sell |
| VSM Wealth Advisory, LLC | 250 | 0 | -250 | 0.00 | 0.00 | -0.00 | sell |
| SHELL ASSET MANAGEMENT CO | 320 | 0 | -320 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 3,077 | 2,722 | -355 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 415 | 0 | -415 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 21,700 | 20,800 | -900 | 0.00 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 2,055 | 1,030 | -1,025 | 0.00 | 0.00 | -0.00 | sell |
| Almitas Capital LLC | 579,997 | 577,807 | -2,190 | 1.29 | 2.15 | +0.85 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 67,190 | 63,990 | -3,200 | 0.00 | 0.00 | +0.00 | sell |
| RBF Capital, LLC | 100,000 | 95,631 | -4,369 | 0.04 | 0.07 | +0.03 | sell |
| RAYMOND JAMES FINANCIAL INC | 7,900 | 0 | -7,900 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 10,580 | 0 | -10,580 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 12,809 | 0 | -12,809 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 27,366 | 11,390 | -15,976 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,419 | 0 | -24,419 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 29,230 | 0 | -29,230 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 39,621 | 0 | -39,621 | 0.00 | 0.00 | -0.00 | sell |
| JOHNSON & JOHNSON | 41,165 | 0 | -41,165 | 0.11 | 0.00 | -0.11 | sell |
| TD ASSET MANAGEMENT INC | 50,232 | 0 | -50,232 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 98,425 | 0 | -98,425 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 306,059 | 13,128 | -292,931 | 0.00 | 0.00 | -0.00 | sell |
| Orland Properties Ltd | 754,698 | 0 | -754,698 | 2.83 | 0.00 | -2.83 | sell |
| MWG Management Ltd. | 1,008,116 | 0 | -1,008,116 | 17.17 | 0.00 | -17.17 | sell |