| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MWG Management Ltd. | 20,162,332 | 20,162,332 | 0 | 30.81 | 17.35 | -13.46 | hold |
| Orland Properties Ltd | 15,093,969 | 15,093,969 | 0 | 13.96 | 14.08 | +0.12 | hold |
| BlackRock, Inc. | 13,747,084 | 13,265,869 | -481,215 | 0.00 | 0.00 | -0.00 | sell |
| Decheng Capital LLC | 0 | 11,909,341 | +11,909,341 | 0.00 | 1.63 | +1.63 | buy |
| VANGUARD GROUP INC | 10,071,482 | 9,766,083 | -305,399 | 0.00 | 0.00 | -0.00 | sell |
| Foresite Capital Management IV, LLC | 8,325,000 | 8,325,000 | 0 | 7.51 | 4.90 | -2.61 | hold |
| Foresite Capital Management V, LLC | 0 | 8,133,047 | +8,133,047 | 0.00 | 4.33 | +4.33 | buy |
| venBio Partners LLC | 0 | 7,102,190 | +7,102,190 | 0.00 | 2.66 | +2.66 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7,352,277 | 6,910,749 | -441,528 | 0.00 | 0.00 | -0.00 | sell |
| Alphabet Inc. | 5,865,125 | 5,865,125 | 0 | 0.44 | 0.22 | -0.22 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 4,019,961 | 4,137,264 | +117,303 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 3,754,745 | +3,754,745 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,889,553 | 3,748,673 | -140,880 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 6,086,001 | 3,103,623 | -2,982,378 | 0.15 | 0.04 | -0.11 | sell |
| HSG Holding Ltd | 3,045,997 | 3,045,997 | 0 | 0.13 | 0.07 | -0.06 | hold |
| MIC Capital Management UK LLP | 1,740,569 | 1,740,569 | 0 | 0.33 | 0.16 | -0.18 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,147,370 | 1,645,787 | +498,417 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 197,400 | 1,612,146 | +1,414,746 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 1,385,301 | +1,385,301 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,356,077 | 1,310,224 | -45,853 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 526,066 | 1,276,037 | +749,971 | 0.23 | 0.23 | +0.01 | buy |
| Almitas Capital LLC | 0 | 1,050,520 | +1,050,520 | 0.00 | 0.15 | +0.15 | buy |
| TD ASSET MANAGEMENT INC | 1,004,642 | 1,004,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 472,626 | 966,265 | +493,639 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 710,067 | 957,507 | +247,440 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 108,713 | 864,287 | +755,574 | 0.00 | 0.00 | +0.00 | buy |
| TAKEDA PHARMACEUTICAL CO LTD | 0 | 823,317 | +823,317 | 0.00 | 1.98 | +1.98 | buy |
| JOHNSON & JOHNSON | 0 | 823,317 | +823,317 | 0.00 | 0.14 | +0.14 | buy |
| GOLDMAN SACHS GROUP INC | 832,323 | 627,321 | -205,002 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 588,235 | 588,235 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 552,556 | 551,851 | -705 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 525,782 | 525,782 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 96,749 | 433,265 | +336,516 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 405,949 | 407,205 | +1,256 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 139,880 | 406,234 | +266,354 | 0.01 | 0.01 | +0.00 | buy |
| Clarius Group, LLC | 399,168 | 399,168 | 0 | 0.04 | 0.02 | -0.02 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 271,996 | 308,551 | +36,555 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 125,700 | 306,400 | +180,700 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 273,771 | 281,129 | +7,358 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 240,615 | 258,380 | +17,765 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 253,669 | +253,669 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 220,790 | 220,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 217,285 | +217,285 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 241,836 | 204,501 | -37,335 | 0.00 | 0.00 | -0.00 | sell |
| BBR PARTNERS, LLC | 164,041 | 164,041 | 0 | 0.02 | 0.01 | -0.01 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 135,050 | 135,050 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 129,303 | 131,877 | +2,574 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 124,320 | 124,320 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SG Americas Securities, LLC | 57,566 | 116,748 | +59,182 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 99,307 | +99,307 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 73,778 | 94,320 | +20,542 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 82,441 | 82,441 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corebridge Financial, Inc. | 85,924 | 79,894 | -6,030 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 37,495 | 69,220 | +31,725 | 0.00 | 0.00 | -0.00 | buy |
| RPO LLC | 0 | 66,378 | +66,378 | 0.00 | 0.06 | +0.06 | buy |
| China Universal Asset Management Co., Ltd. | 49,238 | 59,205 | +9,967 | 0.01 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 45,494 | 58,482 | +12,988 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 55,900 | 55,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 55,539 | 52,935 | -2,604 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 0 | 52,136 | +52,136 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,263 | 51,263 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 49,523 | 49,523 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 144,957 | 48,057 | -96,900 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 30,000 | 40,000 | +10,000 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 37,489 | +37,489 | 0.00 | 0.00 | +0.00 | buy |
| AE Wealth Management LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 22,377 | +22,377 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 117,125 | 19,952 | -97,173 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 8,257 | 19,490 | +11,233 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 11,613 | 18,843 | +7,230 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 14,403 | 17,845 | +3,442 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 17,114 | 17,114 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jefferies Financial Group Inc. | 0 | 16,316 | +16,316 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,024,583 | 16,095 | -1,008,488 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 0 | 15,039 | +15,039 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 116,397 | 15,005 | -101,392 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 16,601 | 13,463 | -3,138 | 0.00 | 0.00 | -0.00 | sell |
| SHELL ASSET MANAGEMENT CO | 127,985 | 12,810 | -115,175 | 0.01 | 0.00 | -0.01 | sell |
| Fortis Capital Management LLC | 12,092 | 12,092 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 122,493 | 11,644 | -110,849 | 0.00 | 0.00 | -0.00 | sell |
| MACKENZIE FINANCIAL CORP | 11,205 | 11,205 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACKENZIE FINANCIAL CORP | 11,205 | 11,205 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Eagle Bay Advisors LLC | 0 | 11,200 | +11,200 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 10,050 | 10,998 | +948 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 11,213 | 10,997 | -216 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 9,259 | 9,305 | +46 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 6,005 | 6,005 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 510 | 5,458 | +4,948 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 5,100 | 5,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 3,164 | 2,487 | -677 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 100 | 2,000 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,165 | 1,165 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 917 | 917 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 119 | 685 | +566 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 617 | +617 | 0.00 | 0.00 | 0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 182 | 182 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Covestor Ltd | 34 | 76 | +42 | 0.00 | 0.00 | 0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 47,763 | 0 | -47,763 | 0.02 | 0.00 | -0.02 | sell |
| BAILLIE GIFFORD & CO | 141,949 | 0 | -141,949 | 0.00 | 0.00 | -0.00 | sell |