| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,159 | 151,016 | +134,857 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 0 | 98,649 | +98,649 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 96,675 | +96,675 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 595,466 | 692,050 | +96,584 | 1.69 | 2.87 | +1.18 | buy |
| MARSHALL WACE, LLP | 0 | 73,315 | +73,315 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 779,004 | 826,430 | +47,426 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 130,257 | 162,997 | +32,740 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 33,752 | 51,472 | +17,720 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,192 | 15,967 | +14,775 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 13,203 | +13,203 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 12,409 | +12,409 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 11,480 | +11,480 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 9,051 | +9,051 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 8,511 | +8,511 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 7,900 | +7,900 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 7,617 | +7,617 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,510 | 85,423 | +5,913 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 176,806 | 181,837 | +5,031 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,030 | 4,233 | +3,203 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 355 | 3,170 | +2,815 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,411 | 32,111 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 28,128 | 30,280 | +2,152 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 743 | 1,031 | +288 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,367 | 3,457 | +90 | 0.00 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 413 | 416 | +3 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,000 | 18,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| ARCH Venture Management, LLC | 2,759,072 | 2,759,072 | 0 | 9.10 | 13.03 | +3.93 | hold |
| Advisors Asset Management, Inc. | 567 | 567 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSG Holding Ltd | 152,299 | 152,299 | 0 | 0.00 | 0.21 | +0.20 | hold |
| Daiwa Securities Group Inc. | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Orland Properties Ltd | 754,698 | 754,698 | 0 | 2.62 | 4.35 | +1.73 | hold |
| Almitas Capital LLC | 577,807 | 577,807 | 0 | 2.15 | 3.92 | +1.77 | hold |
| Alphabet Inc. | 293,256 | 293,256 | 0 | 0.20 | 0.35 | +0.15 | hold |
| Clarius Group, LLC | 19,958 | 19,958 | 0 | 0.02 | 0.04 | +0.02 | hold |
| Foresite Capital Management IV, LLC | 800,399 | 800,399 | 0 | 7.12 | 10.72 | +3.61 | hold |
| Foresite Capital Management V, LLC | 477,078 | 477,078 | 0 | 7.12 | 8.93 | +1.81 | hold |
| MIC Capital Management UK LLP | 87,028 | 87,028 | 0 | 0.28 | 0.61 | +0.32 | hold |
| Susquehanna Portfolio Strategies, LLC | 20,800 | 20,800 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JOHNSON & JOHNSON | 54,887 | 54,887 | 0 | 0.18 | 0.30 | +0.13 | hold |
| GAMMA Investing LLC | 35 | 35 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 58 | 58 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,128 | 13,128 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 162 | 37 | -125 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,858 | 1,194 | -664 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 2,722 | 1,829 | -893 | 0.00 | 0.00 | +0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 2,000 | 1,025 | -975 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 12,234 | 9,516 | -2,718 | 0.01 | 0.01 | +0.00 | sell |
| Ikarian Capital, LLC | 43,799 | 41,081 | -2,718 | 0.14 | 0.16 | +0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 20,827 | 15,616 | -5,211 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 11,390 | 1,657 | -9,733 | 0.00 | 0.00 | -0.00 | sell |
| Rangeley Capital, LLC | 10,000 | 0 | -10,000 | 0.15 | 0.00 | -0.15 | sell |
| Trexquant Investment LP | 10,275 | 0 | -10,275 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 339,491 | 324,701 | -14,790 | 0.00 | 0.01 | +0.00 | sell |
| RBF Capital, LLC | 95,631 | 74,585 | -21,046 | 0.07 | 0.10 | +0.03 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 63,990 | 39,490 | -24,500 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 51,727 | 0 | -51,727 | 0.02 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 125,361 | 58,651 | -66,710 | 0.00 | 0.00 | -0.00 | sell |
| venBio Partners LLC | 473,479 | 337,697 | -135,782 | 4.36 | 4.81 | +0.45 | sell |