| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 0 | 904,017 | +904,017 | 0.00 | 0.30 | +0.30 | buy |
| Woodline Partners LP | 0 | 645,694 | +645,694 | 0.00 | 0.02 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,480,975 | 1,680,975 | +200,000 | 0.60 | 0.36 | -0.25 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 141,519 | +141,519 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 776,082 | 913,399 | +137,317 | 0.04 | 0.03 | -0.01 | buy |
| Almitas Capital LLC | 1,323,667 | 1,452,896 | +129,229 | 1.79 | 1.86 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 87,988 | +87,988 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 215,265 | 288,602 | +73,337 | 0.00 | 0.00 | -0.00 | buy |
| Lynx1 Capital Management LP | 0 | 65,954 | +65,954 | 0.00 | 0.09 | +0.09 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 567,604 | 630,953 | +63,349 | 0.01 | 0.01 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 21,962 | +21,962 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 14,000 | +14,000 | 0.00 | 0.06 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 761,640 | 775,497 | +13,857 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 40,289 | 52,872 | +12,583 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 253,500 | 265,000 | +11,500 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,761 | 7,902 | +6,141 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 39,115 | 44,415 | +5,300 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 958,793 | 963,460 | +4,667 | 0.01 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 54,696 | 58,278 | +3,582 | 0.13 | 0.08 | -0.05 | buy |
| MPM BioImpact LLC | 559,547 | 562,943 | +3,396 | 0.49 | 0.37 | -0.12 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 17,665 | 20,550 | +2,885 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 712 | 2,879 | +2,167 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 2,165 | +2,165 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 29,855 | 31,740 | +1,885 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 3,059 | 3,940 | +881 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,957 | 18,737 | +780 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,451 | 13,069 | +618 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 535 | +535 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,428 | 18,846 | +418 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 350 | +350 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,189 | 1,449 | +260 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 14,266 | 14,383 | +117 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 56,315 | 56,405 | +90 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 11,855 | 11,916 | +61 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 28,094 | 28,129 | +35 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 9,219 | 9,251 | +32 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,887 | 1,895 | +8 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,275 | 2,275 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 239 | 239 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 42,090 | 42,090 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CAZ INVESTMENTS LP | 15,000 | 15,000 | 0 | 0.13 | 0.42 | +0.28 | hold |
| PRINCIPAL SECURITIES, INC. | 74 | 74 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,743,725 | 1,743,725 | 0 | 0.11 | 0.07 | -0.04 | hold |
| Bank of New York Mellon Corp | 95,348 | 95,348 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 12 | 12 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Logos Global Management LP | 4,217,627 | 4,217,627 | 0 | 3.04 | 2.89 | -0.15 | hold |
| Frazier Life Sciences Management, L.P. | 1,953,547 | 1,953,547 | 0 | 0.50 | 0.34 | -0.16 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 9.82 | 6.47 | -3.35 | hold |
| Corient Private Wealth LLC | 26,965 | 26,965 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 19 | 19 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 558 | 558 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,598 | 6,598 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 2,565 | 2,565 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 2,026 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 610 | 610 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,176 | 1,176 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,070 | 12,957 | -113 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 141 | 0 | -141 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 143 | 0 | -143 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 15,610 | 15,383 | -227 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 11,583 | 11,331 | -252 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 19,334 | 18,962 | -372 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 1,005 | 542 | -463 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,006 | 11,357 | -649 | 0.01 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 13,667 | 12,980 | -687 | 0.00 | 0.00 | -0.00 | sell |
| Venturi Wealth Management, LLC | 753 | 0 | -753 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 18,261 | 17,482 | -779 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 16,257 | 15,471 | -786 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 1,070 | 228 | -842 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 24,476 | 22,879 | -1,597 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,430,745 | 1,427,467 | -3,278 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 951,882 | 948,050 | -3,832 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 5,168 | 263 | -4,905 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 264,675 | 258,375 | -6,300 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 52,932 | 46,369 | -6,563 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 723,319 | 714,074 | -9,245 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 32,600 | 22,600 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 11,525 | 0 | -11,525 | 0.00 | 0.00 | -0.00 | sell |
| Bleakley Financial Group, LLC | 13,266 | 0 | -13,266 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 388,125 | 373,653 | -14,472 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 128,400 | 113,800 | -14,600 | 0.02 | 0.01 | -0.01 | sell |
| ALGERT GLOBAL LLC | 16,238 | 0 | -16,238 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 103,571 | 84,006 | -19,565 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 56,617 | 36,917 | -19,700 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 297,129 | 266,016 | -31,113 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 36,099 | 0 | -36,099 | 0.02 | 0.00 | -0.02 | sell |
| Point72 Asset Management, L.P. | 1,856,750 | 1,817,858 | -38,892 | 0.03 | 0.02 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 118,328 | 72,149 | -46,179 | 0.05 | 0.03 | -0.03 | sell |
| Squarepoint Ops LLC | 48,186 | 0 | -48,186 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 48,424 | 0 | -48,424 | 0.03 | 0.00 | -0.03 | sell |
| UBS Group AG | 66,587 | 0 | -66,587 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 89,215 | 19,277 | -69,938 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 203,931 | 128,747 | -75,184 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 233,900 | 146,700 | -87,200 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 2,579,599 | 2,479,963 | -99,636 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 512,330 | 395,251 | -117,079 | 0.00 | 0.00 | -0.00 | sell |