| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 8.67 | 7.59 | -1.08 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,461,381 | 2,972,973 | +1,511,592 | 0.14 | 0.34 | +0.19 | buy |
| Point72 Asset Management, L.P. | 5,372,004 | 2,722,754 | -2,649,250 | 0.08 | 0.05 | -0.03 | sell |
| BAKER BROS. ADVISORS LP | 2,233,099 | 2,585,978 | +352,879 | 0.12 | 0.16 | +0.04 | buy |
| BlackRock, Inc. | 2,117,156 | 2,133,764 | +16,608 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 2,500,000 | 1,950,000 | -550,000 | 1.56 | 1.07 | -0.49 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,179,817 | 1,744,987 | +565,170 | 0.08 | 0.14 | +0.06 | buy |
| Vivo Capital, LLC | 1,612,903 | 1,612,903 | 0 | 0.98 | 1.43 | +0.45 | hold |
| Almitas Capital LLC | 1,530,435 | 1,530,335 | -100 | 3.16 | 3.68 | +0.52 | sell |
| Woodline Partners LP | 944,039 | 961,501 | +17,462 | 0.03 | 0.04 | +0.00 | buy |
| FMR LLC | 771,268 | 798,411 | +27,143 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 784,606 | 784,606 | 0 | 0.48 | 0.53 | +0.05 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 679,590 | 692,518 | +12,928 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 647,636 | 659,575 | +11,939 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 702,306 | 656,565 | -45,741 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 612,768 | 616,481 | +3,713 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 270,654 | 504,718 | +234,064 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 438,894 | 470,270 | +31,376 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 297,921 | 431,840 | +133,919 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 287,100 | 408,200 | +121,100 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 286,572 | 300,279 | +13,707 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 194,611 | 289,385 | +94,774 | 0.01 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 50,023 | 271,554 | +221,531 | 0.01 | 0.06 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 236,863 | 241,485 | +4,622 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 459,874 | 231,513 | -228,361 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 187,769 | 204,739 | +16,970 | 0.03 | 0.03 | +0.01 | buy |
| MARSHALL WACE, LLP | 225,528 | 151,008 | -74,520 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 150,906 | 145,900 | -5,006 | 0.96 | 1.10 | +0.14 | sell |
| Invesco Ltd. | 305,757 | 141,920 | -163,837 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 52,730 | 133,203 | +80,473 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 125,260 | 126,815 | +1,555 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 69,516 | 119,516 | +50,000 | 0.13 | 0.20 | +0.07 | buy |
| Trexquant Investment LP | 99,967 | 117,111 | +17,144 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 180,866 | 108,928 | -71,938 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 109,763 | 108,449 | -1,314 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 226,512 | 103,902 | -122,610 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 86,708 | +86,708 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 46,142 | 86,117 | +39,975 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 84,975 | 79,645 | -5,330 | 0.00 | 0.00 | +0.00 | sell |
| Informed Momentum Co LLC | 78,949 | 78,949 | 0 | 0.08 | 0.10 | +0.01 | hold |
| Palumbo Wealth Management LLC | 69,377 | 71,408 | +2,031 | 0.16 | 0.19 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 57,798 | 65,638 | +7,840 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 35,284 | 60,939 | +25,655 | 0.01 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 54,600 | 60,400 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 87,060 | 55,790 | -31,270 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 78,500 | 52,000 | -26,500 | 0.02 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 94,828 | 50,272 | -44,556 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 46,771 | 50,209 | +3,438 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 50,657 | 49,214 | -1,443 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 46,120 | 46,120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 42,710 | 45,810 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 25,200 | 44,700 | +19,500 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 34,282 | 35,109 | +827 | 0.02 | 0.03 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 158,383 | 34,990 | -123,393 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 34,778 | 34,860 | +82 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 34,183 | +34,183 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 26,965 | 27,169 | +204 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 13,730 | 25,957 | +12,227 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 25,234 | 25,437 | +203 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 15,541 | 20,644 | +5,103 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 20,000 | 20,000 | 0 | 0.11 | 0.13 | +0.02 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,711 | 16,370 | +659 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 46,237 | 16,300 | -29,937 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 14,012 | 16,090 | +2,078 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 15,294 | +15,294 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 15,249 | 15,249 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 7,093 | 15,193 | +8,100 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 11,824 | 14,824 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 14,749 | +14,749 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 14,451 | 14,134 | -317 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 0 | 14,128 | +14,128 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 12,822 | 13,066 | +244 | 0.00 | 0.00 | +0.00 | buy |
| Baader Bank Aktiengesellschaft | 20,000 | 12,792 | -7,208 | 0.02 | 0.01 | -0.00 | sell |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 11,814 | +11,814 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 11,366 | +11,366 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,091 | 11,363 | +272 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 26,786 | 9,027 | -17,759 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 6,598 | 6,598 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 3,113 | 4,263 | +1,150 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 738 | 3,684 | +2,946 | 0.00 | 0.00 | +0.00 | buy |
| CAZ INVESTMENTS LP | 3,500 | 3,500 | 0 | 0.06 | 0.04 | -0.01 | hold |
| Mirae Asset Global Investments Co., Ltd. | 2,768 | 2,971 | +203 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,077 | 2,077 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 2,026 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,816 | 1,816 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,227 | 1,594 | +367 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,273 | 1,545 | -2,728 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 750 | 1,472 | +722 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,471 | 1,292 | -179 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,118 | 1,271 | +153 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 380 | 1,143 | +763 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,377 | 791 | -586 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 610 | 610 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 558 | 533 | -25 | 0.00 | 0.00 | +0.00 | sell |
| Farther Finance Advisors, LLC | 385 | 386 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 268 | 268 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 239 | 239 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Stone House Investment Management, LLC | 0 | 239 | +239 | 0.00 | 0.00 | +0.00 | buy |